NOV 05, 2020 10:33 AM PST

Investigating Platelet-Derived Extracellular Vesicles in Blood Clotting

WRITTEN BY: Jasper Cantrell

In our bodies, there are millions of signals and packages being sent and received every second. In the past several decades, we have increased our understanding of many of these signals yet still have much to learn.

One of these interesting signals is extracellular vesicles (EVs). These are small lipid encapsulated packages that come off of cells, sometimes carrying signal molecules within or being the signal itself. How these cellular packages work is still not well understood, yet recent work suggests they may have more impact than we first thought.

In a new study, a team of scientists from the University of Reading in the United Kingdom began an investigation into platelet-derived extracellular vesicles (PDEVs) and how they change depending on the signal and environment. Platelets are special cells within the blood that are involved in blood clotting. These platelets are responsible for most of the EVs in the blood, and recent work shows that they emerge due to platelet activation. PDEVs, in particular, have been shown to promote clotting.

One of the reasons PDEVs are still not fully understood is that they are challenging to isolate. The team developed a PDEV isolation method using size exclusion chromatography that allowed them to test PDEVs alone. PDEVs have also been shown to be pro-clotting factors in some studies, and the team wanted to see if they could isolate PDEVs from activated platelets and compare them to inactivated PDEVs.

Some studies have shown that PDEV size is related to function, yet the team found that PDEVs isolated from activated platelets versus control platelets had no significant size difference. They also noted that the activating factor did not change the PDEVs clotting activity due to surface changes on the PDEVs themselves, as some other studies have shown. PDEVs from two different sources also produced different clotting properties.

This study showed that while previous studies have demonstrated platelet-derived extracellular vesicles (PDEVs) from activated platelets could promote clotting, isolated PDEVs from activated platelets from different sources had two different activities. This inferred a more complex pathway for PDEV generation. The study also revealed a method of PDEV isolation that could help future studies down the line.

The study concludes, “this study demonstrates that the mechanism by which PDEV formation is induced is a critical determinant of their phenotype, but not size. PDEVs derived via different mechanisms exhibited different procoagulant properties.”

Sources: Nature Scientific Reports, nemotion

About the Author
  • Hey everyone! My name is Jasper and, considering I am pretty new here to Labroots, I figured I would introduce myself. I received my bachelor’s from the University of California at Riverside back in 2016. I started off my career a few years ago with a job at a University over in New York, before moving over into the industry. I'm happy to be writing content for Labroots, and I hope you enjoy it!
You May Also Like
JUL 04, 2020
Cardiology
Discovering a New Signal Junction Controlling Pulmonary Arterial Hypertension
JUL 04, 2020
Discovering a New Signal Junction Controlling Pulmonary Arterial Hypertension
Pulmonary Arterial Hypertension (PAH) is a progressive and fatal disease characterized by the muscularization of blood c ...
AUG 04, 2020
Cardiology
Does Chronic Anxiety Affect Heart Health?
AUG 04, 2020
Does Chronic Anxiety Affect Heart Health?
Anxiety is something that is talked about far more often nowadays. In recent years, it has even been linked to a variety ...
AUG 07, 2020
Cardiology
CT Method Can Find New Ways to Improve CPR
AUG 07, 2020
CT Method Can Find New Ways to Improve CPR
The time it takes for a person experiencing cardiac arrest to get help can make the difference between life and death.
SEP 03, 2020
Cardiology
Does Hypertension Make It Harder to Recognize Others Emotions?
SEP 03, 2020
Does Hypertension Make It Harder to Recognize Others Emotions?
Have you ever felt your blood pressure rise when you get angry or stressed? Well, this phenomenon is unique in that it l ...
OCT 12, 2020
Cardiology
Pig Hearts Might be Used in Human Transplants by the End of 2021
OCT 12, 2020
Pig Hearts Might be Used in Human Transplants by the End of 2021
A major problem in the transplant field is a lack of healthy donor organs. For many years, scientists in the field of re ...
NOV 10, 2020
Cardiology
Liposomal Delivery Could Help Prevent Doxorubicin Cardiotoxicity
NOV 10, 2020
Liposomal Delivery Could Help Prevent Doxorubicin Cardiotoxicity
One of the greatest failures of modern cancer therapies is the rather substantial off-target toxic effects many radio-, ...
Loading Comments...