DEC 03, 2015 11:51 AM PST

Heart Failure Caused By Mitochondrial Defect

WRITTEN BY: Kara Marker
A large amount of energy is required for cardiomyocytes, muscle cells of the heart, to perform all of the vital functions of the heart, pumping blood and delivering nutrients and oxygen to the body tissues. Mitochondria provide the energy needed for these processes by metabolizing organic molecules like sugar, fatty acids, and amino acids. However, when a mitochondrial defect reduces the amount of energy cardiomyocytes receive for pumping blood, the heart can fail to deliver oxygen needed for the body to function.

Dilated cardiomyopathy (DCM) is a relatively common disorder that exhibits an inability of the heart to pump blood, because the "main pumping chamber" expands, weakens, and loses the ability to contract as needed (MedicineNet). This week in a study published in Science by scientists from Centro Nacional de Investigaciones Cardiovasculares Carloss III (CNIC) in Madrid and the Research Institute CECAD/Max Planck in Cologne, a team of researchers investigated the role of protein YME1 in the regulation of mitochondria.

When YME1 is missing, a mitochondrial defect is seen that leads to heart failure in cases of DCM. The team of scientists from Madrid and Cologne looked to reversing this defect to increase the lifespan of heart failure patients. 
PET scans of a healthy mouse (left) and a mouse with a mitochondrial defect leading to DCM (right)

Unlike healthy people, patients with a mitochondrial defect causing DCM have cardiomyocytes that consume more sugars than fatty acids. Since fatty acids have more energy, DCM patients receive much less energy for powering the heart than healthy people do. During a study on reversing this effect, experimental mouse models of DCM were fed a high-fat diet in attempt to "force the heart cells to consume more fatty acids than sugars, and thus 'bypass' the mitochondrial defect,” explained Dr. Jaime Garcia-Prieto, one of two first authors of the study. The attempt was successful in overriding the mitochondrial defect, improving heart function, and increasing the lifespan of the experimental mice.

Although this study showed positive results, doctors are not yet jumping to feed all of their heart failure patients large amounts of fatty foods.

"We know that a diet rich in fats is a threat to health because it increases the incidence of atherosclerosis. The possibility that such a diet might be beneficial in certain cases of heart disease is very provocative and attractive. However, much translational research needs to be done before these results can be considered definitive,” said Valentin Fuster, MD, PhD, and General Director of the CNIC.

Watch the following video to learn more about cardiomyopathy under different circumstances.

Source: CNIC
About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
NOV 11, 2019
Cardiology
NOV 11, 2019
It's Never Too Late To Start Exercising
It’s easy to feel like you’ve missed the opportunity to enjoy the benefits of exercise. For older adults, the lean, strong body associated with...
NOV 11, 2019
Cardiology
NOV 11, 2019
The Female Athlete Triad
The Female Athlete Triad is a combination of three interconnected health issues. The three components are energy deficiency, menstrual disturbances (amenor...
NOV 11, 2019
Cardiology
NOV 11, 2019
Helping Hearts Heal After Cardiac Events With Stem Cells
Heart disease kills more people worldwide than any other cause. In America, it is the number one reason people are admitted to the hospital. Additionally, ...
NOV 11, 2019
Drug Discovery & Development
NOV 11, 2019
Medications Used for Atrial fibrillation May Increase Falls
Falls among older adults are a growing health concern that often lead to injury, hospitalization, and other severe complications. Older adults are even at...
NOV 11, 2019
Cardiology
NOV 11, 2019
Cardiac Mapping for Arrhythmia Diagnosis
Cardiac mapping is an essential diagnostic tool. These imagining tools are used for diagnosing arrhythmias in the heart. Cardiac mapping can be done in sev...
NOV 11, 2019
Clinical & Molecular DX
NOV 11, 2019
A Revealing Look at Rare Disease Incidence
Being diagnosed with a rare disease can be especially terrifying for patients. After all, many of these diseases have no treatment options. This is because...
Loading Comments...