JAN 27, 2016 8:16 AM PST

Preventing Heart Failure After Acute Myocardial Infarction

WRITTEN BY: Kara Marker
Acute myocardial infarction (AMI) leads to lethal cardiac failure after oxygen depletion in the heart exceeds a “critical threshold” required for healthy cellular repair mechanisms. Without ample blood supply to the heart, heart cells either die or are damaged irreversibly (Cleveland Clinic).
 
Scientists from Osaka University, in their recent Hypertension paper, investigated ways to prevent cardiac failure from AMI, focusing on periostin, a group of extracellular matrix proteins (Gene ID).
 
After AMI starts to develop, fibroblasts secrete periostin to heal and regenerate damaged tissue. However, the team from Osaka confirmed that “cell adhesion inhibition” of periostin1 actually causes damage to myocardial cells, promotes myocyte death, and exacerbates the conditions leading to heart failure.
 

A treatment that inhibits periostin proteins seemed to be the answer to reducing heart failure risk, but the results from that treatment were twofold. Without periostin1, heart failure following AMI was suppressed, but death from cardiac rupture following AMI increased.
 
The team from Osaka identified this effect as a result of differing functions among periostin variants. While periostin1 leads to cardiac failure outcomes, periostin2 and periostin4 actually have cardioprotective effects:
  • Myocardial regeneration
  • Angiogenesis
  • Protection from cardiac rupture after AMI
Subsequently, their most successful treatment for preventing cardiac failure after AMI inhibited periostin1 without inhibiting periostin2 and periostin4. The treatment was developed with periostin variant-specific neutralizing antibodies.
 
This new therapeutic method provides patients with an improved quality of life as well as decreases medical spending on cardiac failure treatment.
 
 
Source: Osaka University
 
About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
JUN 17, 2019
Health & Medicine
JUN 17, 2019
Not Just Risk Factors: Researchers Prove Excess Weight & Body Fat Cause Heart Disease
For decades, scientists and doctors alike have known that excess weight and body fat are risk factors for cardiovascular diseases. However, a new study has...
SEP 18, 2019
Cardiology
SEP 18, 2019
Clear, Flexible Vital Sign Wearable Monitors
Wearable health monitors are gaining in popularity, both for fitness tracking and for gathering more targeted health data relating to heart disease and oth...
OCT 10, 2019
Cardiology
OCT 10, 2019
Parkinson's Disease is Present in the Blood
Parkinson's disease is a progressive disorder of the nervous system. Often starting with a barely noticeable tremor in one hand, the disease affects a...
OCT 09, 2019
Cardiology
OCT 09, 2019
Diagnosed With Atopic Dermatitis?
Eczema, dermatitis, atopic dermatitis: all names for the same disease of the skin. Although common in children during the first year of life, the condition...
NOV 01, 2019
Cardiology
NOV 01, 2019
Meal Timing May Have a Profound Influence on Your Workout
A new study, published in the Journal of Clinical Endocrinology and Metabolism, sought to examine the relationship between meal timing, fat storage, and in...
OCT 30, 2019
Genetics & Genomics
OCT 30, 2019
Disruptions in Mitochondrial Quality Control Can Cause Heart Disease
Researchers have learned why mutations in the ANT gene lead to heart problems....
Loading Comments...