JUN 10, 2016 09:29 AM PDT

Cardiac Troponin T Assay Improves Heart Disease Diagnoses

WRITTEN BY: Kara Marker
Cardiac troponin T is a protein biomarker detectable with a blood test, and it is the preferred biomarker for determining cardiovascular risk. In a new study published in JAMA Cardiology, researchers from the Johns Hopkins Bloomberg School of Public Health introduce and test a high-sensitivity cardiac troponin T (hs-cTnT) assay for increasing diagnostic accuracy.

Image credit: www.emdocs.net 
Whether it’s coronary heart disease, heart failure, or even all-cause mortality, elevated hs-cTnT levels are all present. However, researchers have yet to completely understand how these levels fluctuate over time. The hs-cTnT assay in this study allows even the lowest levels of cardiac troponin T to be detected, so scientists can achieve a fuller vision of how this biomarker truly characterizes different states of cardiovascular disease.
 
The novel assay, an altered version of a fourth-generation cTnT assay, was used in the study with 8,838 participants from the Atherosclerosis Risk in Communities Study. All participants, 59 percent female and 21 percent black, were initially free of both coronary heart disease and heart failure. The average age of participants was 56 years.
 
The researchers measured hs-cTnT twice, six years apart. At the second measurement event, they calculated 1,157 cases of coronary heart disease, 965 heart failure evens, and 1,813 deaths.
 
Of the nearly 4,000 study participants who either had coronary heart disease, heart failure, or died, their hs-cTnT levels were significantly increased: from less than 0.0005 ng/ml at the first measurement time to 0.014 ng/ml at the 6-year follow-up. On the other hand, for people who appeared free of cardiovascular disease after the follow-up, their lower risk of dangerous cardiovascular outcomes was accompanied by decreasing levels of hs-cTnT. In fact, the reductions were greater than 50 percent from the baseline value of 0.0005 ng/ml.
 
With clear evidence for the efficacy of a new assay for measuring the cardiac troponin T biomarker for cardiovascular disease, scientists are hopeful that doctors will soon be able to use applications of this assay to make more accurate and quick diagnoses. For heart disease, which remains the global leading cause of death at 17.3 million deaths per year, enhancing diagnoses could save many lives.
 

 
Sources: The JAMA Network Journals, Journal of Geriatric Cardiology, the American Heart Association
 
About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
AUG 21, 2019
Cardiology
AUG 21, 2019
Banishing Heart Disease Myths
There are a number of myths surrounding heart disease. This can be dangerous for heart patients, and their children, if allowed to interfere with heart-hea...
AUG 21, 2019
Cardiology
AUG 21, 2019
Body Mass Index Scores Are Prone To Inaccuracy
Body mass index (BMI) scoring is a highly problematic method of calculating a person's body fat percentage. The BMI chart has wholly neglected to ackno...
AUG 21, 2019
Health & Medicine
AUG 21, 2019
Glue, It's What Keeps A Heart Together
If you’ve ever had a cavity filled at the dentist, you know the steps. First goes in the filling, followed by a wand of UV light to harden the materi...
AUG 21, 2019
Health & Medicine
AUG 21, 2019
Can Sauna Sessions Replace Exercise?
A moderate sauna session after a workout or spa treatment can be quite relaxing. A new study from Germany's Martin Luther University Halle-Wittenberg (...
AUG 21, 2019
Cardiology
AUG 21, 2019
Understanding Endocarditis
The endocardium is the inner lining of the heart chambers and valves. Endocarditis is an infection of this lining. If not treated quickly, endocarditis can...
AUG 21, 2019
Cardiology
AUG 21, 2019
Paleo Diet Alters Microbiome, May Harm Heart
New findings have raised concerns over the Paleolithic or Paleo diet. Recent research into the diet suggests that it lacks key nutritional components relat...
Loading Comments...