JUN 21, 2016 05:52 PM PDT

How bad is YOUR pulmonary arterial hypertension?

WRITTEN BY: Kara Marker
For unknown reasons, a new study has uncovered the ability of a protein called hepatoma derived growth factor (HDGF) to determine how severe a certain case of pulmonary arterial hypertension (PAH) is in a patient. There is currently no cure for PAH, but this research is helping doctors improve diagnostics and develop better treatment plans.
Credit: www.eigerbio.com
PAH is a chronic condition that puts stress on the heart as it tries to push blood through narrowed arteries of the lungs that grow stiff and tight over time. Affecting approximately 200,000 Americans, PAH can be inherited or occur as a result of infections, congenital heart disease, connective tissue disorders, or continuous exposure to a high-altitude environment. Most people afflicted with PAH have almost no other health problems and are often relatively young. Drugs are available to alleviate symptoms and attempt to improve blood flow, and lung transplant procedures are done if nothing else seems to work.
 
PAH has historically been hard to diagnose and assess if a patient is improving or worsening, especially in children. From Johns Hopkins Medicine, scientists bring a light amidst the darkness of this disease. They’ve developed a noninvasive test for PHA using HDGF to make more accurate diagnoses of patients so they can receive the right medication for their condition. In the past doctors have used an invasive procedure called cardiac catheterization, but the new test is more specific and can accurately portray the current health status of the lungs.
 
The Johns Hopkins researchers confirmed the connection of HDGF to PAH status by conducting a series of comparisons between healthy people and PAH patients. They used blood samples from 39 PAH patients considered severe cases because treatment hadn’t worked, and they were on the waiting list for lung transplants. These samples were compared to a group of 39 healthy volunteers with the same ratio of ages, races, and gender. The median level of HDGF in the healthy group was 0.29 nanograms per mL, but the median level of HDGF in the PAH patients was a whopping 1.93.
 
Continuing with a follow-up study, the researchers collected an additional 73 blood samples from PAH patients, this time over five years, comparing results between survivors and non-survivors. HDGF was lower in survivors than in non-survivors, and an HDGF reading of over 0.7 indicated more severe heart damage and shorter distances achieved in a six-minute walking test. This study also showed that higher levels of HDGF made PAH patients 4.5 times as likely to die, even after adjusting the data for a variety of potentially skewing factors.
 
With these trials completed and data analyzed, the Johns Hopkins researchers knew that elevated levels of HDGF indeed indicated a more severe case of PAH, but they still don’t know what biochemical processes are causing the association. HDGF is known to be important for forming new blood vessels in the lung, and it also has “mitogenic and DNA-binding activity.” Elevated HDGF expression has also been implicated in cases of enhanced tumor growth, but scientists aren’t sure if that is even related to the current study.
 
Senior author Allen Everett, M.D. thinks that HDGF levels might rise to prompt blood vessel repair when arteries in the lungs are strained due to PAH. For now, Everett is satisfied to declare HDGF as a useful diagnostic tool for determining PAH severity. For tomorrow, he’ll answer why.
 

 
Sources: Johns Hopkins Medicine, American Journal of Respiratory and Critical Care Medicine, Pulmonary Hypertension Association, National Center for Biotechnology Information
 
About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
NOV 13, 2018
Microbiology
NOV 13, 2018
How the Microbiome, Fiber, and Heart Health are Linked
High-fiber diets are linked to better health, including healthier hearts and arteries, but why?...
NOV 16, 2018
Technology
NOV 16, 2018
An App That Detects Fatal Heart Attacks?
Imagine having a smart phone that is capable of determining a fatal heart attack? An international research study has found that an app is capable of ident...
JAN 29, 2019
Cell & Molecular Biology
JAN 29, 2019
Understanding Why Some People Get Arrhythmia After a Heart Attack
About 23% of people carry a genetic mutation that predisposes them to get arrhythmia after a heart attack, and researchers know how it happens....
FEB 01, 2019
Drug Discovery
FEB 01, 2019
Statin Therapy Reduces Risk of Cardiovascular Complications Regardless of Age
A meta-analysis study, from randomized clinical trials, found that regardless of age, statin therapy is effective in decreasing the risk of developing vasc...
FEB 17, 2019
Cardiology
FEB 17, 2019
Woman Nearly Twice As Likely To Die After Surgery
An aortic dissection is a tear in the large artery that supplies oxygenated blood to the body. This happens most often in older patients in their 60’...
FEB 25, 2019
Cardiology
FEB 25, 2019
We Can Do Better Than Stitches For Wounds
If you’ve made it into adulthood chances are you’ve suffered some flesh wounds over the years. Some of these may have required stitches which, ...
Loading Comments...