Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
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DATE: January 30, 2019 TIME: 8:00am PDT In the recent decade, mass spectrometry has become the method of choice for certain laboratory tests, like steroid hormones, pain management drugs, an...Speaker: Xin Yi, PhDDEC 11, 2019 07:00 AM PSTC.E. CREDITS
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DATE: January 30, 2019 TIME: 8:00am PDT In the recent decade, mass spectrometry has become the method of choice for certain laboratory tests, like steroid hormones, pain management drugs, an...
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LabRoots and the Cell Biology Planning Committee are please to announce the 4th Annual Cell Biology Virtual Event, providing an opportunity to discuss recent discoveries in biological researc...SEP 26, 2019 06:00 AM PDTC.E. CREDITS
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