Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
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DATE: April 1, 2020 TIME: 8:00am PST The capabilities of liquid chromatography coupled to mass spectrometry make the technology a very attractive tool in clinical laboratory settings. Howeve...Speaker: Adam McShane, PhD, DABCCAPR 23, 2020 9:00 AM PDTAdd to Calendar Select one of the following:
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Date: April 23, 2020 Time: 9:00am PDT, 12:00pm EDT Analytical quality control refers to all those processes and procedures designed to ensure that the results of laboratory analysis are cons...Speaker: Joy McElroySponsored By: SartoriusFEB 18, 2020 8:00 AM PSTC.E. CREDITS
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DATE: April 1, 2020 TIME: 8:00am PST The capabilities of liquid chromatography coupled to mass spectrometry make the technology a very attractive tool in clinical laboratory settings. Howeve...
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APR 23, 2020
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Date: April 23, 2020 Time: 9:00am PDT, 12:00pm EDT Analytical quality control refers to all those processes and procedures designed to ensure that the results of laboratory analysis are cons...
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Luminex's xMAP® Technology enables the evaluation of up to 500 analytes simultaneously in a single well, known as multiplexing. xMAP Technology uses color-coded microspheres as the substrate...SEP 23, 2020 6:00 AM PDTAdd to Calendar Select one of the following:
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LabRoots and the Cell Biology Planning Committee are please to announce the 4th Annual Cell Biology Virtual Event, providing an opportunity to discuss recent discoveries in biological researc...SEP 26, 2019 6:00 AM PDTC.E. CREDITS
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Luminex's xMAP® Technology enables the evaluation of up to 500 analytes simultaneously in a single well, known as multiplexing. xMAP Technology uses color-coded microspheres as the substrate...
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LabRoots and the Cell Biology Planning Committee are please to announce the 4th Annual Cell Biology Virtual Event, providing an opportunity to discuss recent discoveries in biological researc...
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