Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
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SEP 18, 2019Drug Discovery & Development
SEP 18, 2019In recent years, ketamine has received growing interest for its neuroprotective effects. Known to alleviate symptoms of depression in just hours whereas co...Written By: Annie LennonAUG 13, 2019Genetics & Genomics
AUG 13, 2019Researchers are taking a new look at how the cell regulates gene expression....Written By: Carmen LeitchAUG 11, 2019Immunology
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AUG 05, 2019Scientists have improved on a recently-developed method for visualizing the interactions between DNA and proteins....Written By: Carmen Leitch
SEP 18, 2019
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Calprotectin is a member of the S100 family of calcium binding proteins, being a hetero dimmer of S100A8/9 and accounts for 60% of the protein in the cytoplasm of neutrophils. It is released...Speaker: Roy Sherwood, BSc, MSC, DPhilPresented At:Discover More; Your Virtual ResourceNOV 18, 2019 08:00 AM PSTAdd to Calendar Select one of the following:
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DATE: November 18, 2019TIME: 8:00am PST, 11:00am EST, 4:00pm CEWT How often do you pipette in your cell culture lab every day? Usually, we do it so often that we tend stop th...Speaker: Nadine Mellies, PhD , Katja Baesler, PhDSponsored By: EppendorfDEC 11, 2019 07:00 AM PSTAdd to Calendar Select one of the following:
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DATE: December 11, 2019TIME: 7:00am PST, 10:00am EST An important part of the biopharma industry, Plasmid DNA is used as a gene-delivery vehicle for DNA vaccination and as a key...Speaker: Colleen ReedSponsored By: SCIEXSEP 05, 2019 04:00 PM CESTC.E. CREDITS
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JUN 05, 2019 05:00 PM CESTDATE: June 5, 2019TIME: 8:00am PDT, 11:00am EDT, 5:00pm CEST Eukaryotic cell cultures respond to the most subtle influence. Apart from the risk of contamination, minimal chan...Speaker: Jessica Wagener, PhDSponsored By: Eppendorf
OCT 22, 2019
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OCT 22, 2019
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Calprotectin is a member of the S100 family of calcium binding proteins, being a hetero dimmer of S100A8/9 and accounts for 60% of the protein in the cytoplasm of neutrophils. It is released...
Speaker:
Roy Sherwood, BSc, MSC, DPhil
Presented At:Discover More; Your Virtual Resource
NOV 18, 2019
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DATE: November 18, 2019TIME: 8:00am PST, 11:00am EST, 4:00pm CEWT How often do you pipette in your cell culture lab every day? Usually, we do it so often that we tend stop th...
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Nadine Mellies, PhD
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Katja Baesler, PhD
Sponsored By: Eppendorf
DEC 11, 2019
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DATE: December 11, 2019TIME: 7:00am PST, 10:00am EST An important part of the biopharma industry, Plasmid DNA is used as a gene-delivery vehicle for DNA vaccination and as a key...
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Colleen Reed
Sponsored By: SCIEX
SEP 05, 2019
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Tim Schommartz, PhD
Sponsored By: Eppendorf
JUN 05, 2019
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DATE: June 5, 2019TIME: 8:00am PDT, 11:00am EDT, 5:00pm CEST Eukaryotic cell cultures respond to the most subtle influence. Apart from the risk of contamination, minimal chan...
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Jessica Wagener, PhD
Sponsored By: Eppendorf
MAY 16, 2019
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MAY 16, 2019
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DATE: May 16, 2019TIME: 7:00am PDT, 10:00am EDT, 4:00pm CEST The emergence of NGS is revolutionizing the microbiological sciences and transforming medicine. Deep sequencing has...
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Christiane Honisch, PhD
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DATE: April 9, 2019TIME: 9:00 AM PDTWe will provide a general introduction to the Single-Cell Western Technology (SCW) and then present data from 2 ongoing projects from the Col...
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Kelly Gardner, Ph.D.
Sponsored By: ProteinSimple
MAR 26, 2019
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NanoMIPs, often called “plastic antibodies”, are made using a proprietary self-assembly process where the template molecule is incubated with monomers, each of which is free in so...
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LabRoots and the Cell Biology Planning Committee are please to announce the 3rd Annual Cell Biology Virtual Event, providing an opportunity to discuss recent discoveries in biological researc...SEP 23, 2020 06:00 AM PDTAdd to Calendar Select one of the following:
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LabRoots and the Cell Biology Planning Committee are please to announce the 4th Annual Cell Biology Virtual Event, providing an opportunity to discuss recent discoveries in biological researc...JUN 05, 2019 06:00 AM PDTC.E. CREDITS
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LabRoots and the Cell Biology Planning Committee are please to announce the 3rd Annual Cell Biology Virtual Event, providing an opportunity to discuss recent discoveries in biological researc...
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LabRoots and the Cell Biology Planning Committee are please to announce the 4th Annual Cell Biology Virtual Event, providing an opportunity to discuss recent discoveries in biological researc...
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Welcome to Laboratory Automation 2018; a free virtual conference for professionals interested in the most recent technologies for today’s labs. Laboratory automation is a multi-discipli...
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