Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
What's Popular in Protein Binding
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SEP 27, 2018 08:00 AM PDTC.E. CREDITS
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SEP 27, 2018
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LIVE NOW!
LabRoots invites you to the 9th Annual Clinical Diagnostics & Research free online conference! Clinical diagnostics is an ever-changing field of medicine and research, challenged with com...
SEP 26, 2019
06:00 AM PDT
Add to Calendar
Select one of the following:
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Google Calendar
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SEP 26, 2019
06:00 AM PDT
Add to Calendar
Select one of the following:
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iCal
Google Calendar
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- Cell Line Development
- Protein Chemistry
- Systems Biology
- Biology
- Blood
- Cell Therapy
- Clinical Trials
- Chemical Biology
- DNA-Binding Proteins
- Human Biology
- Protein Biochemistry
- Protein Expression
- Protein Interaction
- Small Molecule
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- Cancer Therapeutics
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- Antibodies
- Animal Models
- Clinical Research
- DNA
- Immunology
- Genomics
- Genetics
- Gene Therapy
- Gene Expression
- Drug Discovery
- Heart Disease
- Vaccine
- Medicine
- Antibody-Based Protein
