Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
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DEC 02, 2020 8:00 AM PSTC.E. CREDITS
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DEC 15, 2020 10:00 AM PSTAdd to Calendar Select one of the following:
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DEC 15, 2020
10:00 AM PST
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DATE: December 15, 2020 TIME: 10:00am PST Scientists from Thermo Fisher Scientific will walk us through the world of microorganisms. They will discuss their most recent research on viruses,...
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SEP 22, 2021 6:00 AM PDTAdd to Calendar Select one of the following:
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SEP 22, 2021
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LabRoots and the Cell Biology Planning Committee are pleased to announce the 5th Annual Cell Biology Virtual Event , providing an opportunity to discuss recent discoveries in biological res...
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