Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
What's Popular in Protein Binding
-
OCT 20, 2021Genetics & Genomics
OCT 20, 2021In the human eye, a space called the anterior chamber sits in between the cornea, which is a clear layer in the front of ...Written By: Carmen LeitchOCT 19, 2021Immunology
OCT 19, 2021In patients with hemophilia A—a hereditary disorder where the blood cannot clot properly—their immune system ...Written By: Tara FernandezOCT 14, 2021Genetics & Genomics
OCT 14, 2021Respiratory syncytial virus (RSV) are thought to be incredibly common; research has suggested that almost everyone is ev ...Written By: Carmen LeitchOCT 14, 2021Cancer
OCT 14, 2021Colorectal cancer develops when a series of changes occur across multiple genes. While researchers have paid signi ...Written By: Katie KokolusOCT 07, 2021Clinical & Molecular DX
OCT 07, 2021Viruses are natures shapeshifters; their genomes are in a constant state of flux as they divide in their hosts. Over tim ...Written By: Tara Fernandez
OCT 20, 2021
Genetics & Genomics
OCT 20, 2021
In the human eye, a space called the anterior chamber sits in between the cornea, which is a clear layer in the front of
...
Written By:
Carmen Leitch
OCT 19, 2021
Immunology
OCT 19, 2021
In patients with hemophilia A—a hereditary disorder where the blood cannot clot properly—their immune system
...
Written By:
Tara Fernandez
OCT 14, 2021
Genetics & Genomics
OCT 14, 2021
Respiratory syncytial virus (RSV) are thought to be incredibly common; research has suggested that almost everyone is ev
...
Written By:
Carmen Leitch
OCT 14, 2021
Cancer
OCT 14, 2021
Colorectal cancer develops when a series of changes occur across multiple genes. While researchers have paid signi
...
Written By:
Katie Kokolus
OCT 07, 2021
Clinical & Molecular DX
OCT 07, 2021
Viruses are natures shapeshifters; their genomes are in a constant state of flux as they divide in their hosts. Over tim
...
Written By:
Tara Fernandez
OCT 04, 2021
Cell & Molecular Biology
OCT 04, 2021
Neurons signal to one another at crucial junctions called synapses, and synaptic dysfunction is thought to play a role i
...
Written By:
Carmen Leitch
SEP 27, 2021
Microbiology
SEP 27, 2021
Rift Valley fever virus is carried by mosquitoes, and when it's passed to livestock including cattle, goats, and sheep,
...
Written By:
Carmen Leitch
SEP 26, 2021
Genetics & Genomics
SEP 26, 2021
Muscle diseases that have a genetic basis can cause muscles to waste away, and may lead to a premature death. There aren
...
Written By:
Carmen Leitch
SEP 26, 2021
Coronavirus
SEP 26, 2021
Humans can produce millions or even billions of antibodies, so only so many can be captured and screened. But those anti
...
Written By:
Carmen Leitch
-
Date: November 8, 2021 Time: 8:00am (PDT), 11:00am (EDT) Explore the adaptability of your KingFisher instrument. Discover all the ways your Thermo Scientific™ KingFisher™ system...Speaker: Ketil Pedersen, Ph.D , Emily Zeringer , Suraj Patel, Ph.D.Sponsored By: Thermo Fisher ScientificOCT 20, 2021 9:00 AM PDTC.E. CREDITS
OCT 20, 2021 9:00 AM PDTDate: October 20, 2021 Time: 9:00am PDT Cryo-electron microscopy (cryo-EM) is rapidly evolving to be the primary tool for structure determination of membrane proteins. However, generation of...Speaker: Ieva Drulyte, PhD , Michael Liss, PhD , Jens Frauenfeld, PhDPresented at: Thermo Fisher Scientific - Electron Microscopy WebinarsSponsored By: Thermo Fisher Scientific.OCT 14, 2021 9:00 AM PDTC.E. CREDITS
OCT 14, 2021 9:00 AM PDTDate: October 14, 2021 Time: 9:00am (PDT), 12:00pm (EDT), 5:00pm GMT Western blot analysis is a method widely used in the lab today because of its versatility in detecting and measuring spe...Speaker: Kelli Feather-HeniganPresented at: Webinar series: Simple steps to publication-quality western blotsSponsored By: Thermo Fisher ScientificOCT 14, 2021 7:00 AM PDTC.E. CREDITS
OCT 14, 2021 7:00 AM PDTDate: October 14, 2021 Time: 7:00am (PDT), 10:00am (EDT) Heterologous protein expression in model organisms has many applications, including protein engineering, production of industrial enz...Speaker: Tyson Shepherd, PhDSponsored By: InscriptaOCT 13, 2021 7:00 AM PDTC.E. CREDITS
OCT 13, 2021 7:00 AM PDTDate: October 13, 2021 Time: 7:00am (PDT), 10:00am (EDT) Western blot analysis is a method widely used in the lab today because of its versatility in detecting and measuring specific target...Speaker: Caleb ShearrowPresented at: Webinar series: Simple steps to publication-quality western blotsSponsored By: Thermo Fisher Scientific
Date: November 8, 2021 Time: 8:00am (PDT), 11:00am (EDT) Explore the adaptability of your KingFisher instrument. Discover all the ways your Thermo Scientific™ KingFisher™ system...
Speaker:
Ketil Pedersen, Ph.D
,
Emily Zeringer
,
Suraj Patel, Ph.D.
Sponsored By: Thermo Fisher Scientific
OCT 20, 2021
9:00 AM PDT
C.E. CREDITS
OCT 20, 2021
9:00 AM PDT
Date: October 20, 2021 Time: 9:00am PDT Cryo-electron microscopy (cryo-EM) is rapidly evolving to be the primary tool for structure determination of membrane proteins. However, generation of...
Speaker:
Ieva Drulyte, PhD
,
Michael Liss, PhD
,
Jens Frauenfeld, PhD
Presented at: Thermo Fisher Scientific - Electron Microscopy WebinarsSponsored By: Thermo Fisher Scientific.
OCT 14, 2021
9:00 AM PDT
C.E. CREDITS
OCT 14, 2021
9:00 AM PDT
Date: October 14, 2021 Time: 9:00am (PDT), 12:00pm (EDT), 5:00pm GMT Western blot analysis is a method widely used in the lab today because of its versatility in detecting and measuring spe...
Speaker:
Kelli Feather-Henigan
Presented at: Webinar series: Simple steps to publication-quality western blotsSponsored By: Thermo Fisher Scientific
OCT 14, 2021
7:00 AM PDT
C.E. CREDITS
OCT 14, 2021
7:00 AM PDT
Date: October 14, 2021 Time: 7:00am (PDT), 10:00am (EDT) Heterologous protein expression in model organisms has many applications, including protein engineering, production of industrial enz...
Speaker:
Tyson Shepherd, PhD
Sponsored By: Inscripta
OCT 13, 2021
7:00 AM PDT
C.E. CREDITS
OCT 13, 2021
7:00 AM PDT
Date: October 13, 2021 Time: 7:00am (PDT), 10:00am (EDT) Western blot analysis is a method widely used in the lab today because of its versatility in detecting and measuring specific target...
Speaker:
Caleb Shearrow
Presented at: Webinar series: Simple steps to publication-quality western blotsSponsored By: Thermo Fisher Scientific
OCT 12, 2021
5:00 PM PDT
C.E. CREDITS
OCT 12, 2021
5:00 PM PDT
Date: October 12, 2021 Time: 5:00pm (PDT), 8:00pm (EDT) 222 Learning Objectives 222 222 222 Webinars will be available for unlimited on-demand viewing after live event. LabRoots is approved...
Speaker:
Jordan Thompson, PhD
Presented at: Webinar series: Simple steps to publication-quality western blotsSponsored By: Thermo Fisher Scientific
SEP 14, 2021
7:00 AM PDT
C.E. CREDITS
SEP 14, 2021
7:00 AM PDT
Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
Speaker:
Arora Phang, PhD
Sponsored By: Eppendorf
AUG 25, 2021
9:00 AM PDT
C.E. CREDITS
AUG 25, 2021
9:00 AM PDT
Date: August 25, 2021 Time: 9:00am PDT During this interactive webinar you can ask questions, get answers, and engage with Taiana De Oliveira from AstraZeneca, Steven Litster, Brian Skjerven...
Speaker:
Taiana Maia de Oliveira
,
Steve Litster
,
Brian Skjerven
,
Natalie White
,
Ieva Drulyte, PhD
Presented at: Thermo Fisher Scientific - Electron Microscopy WebinarsSponsored By: Thermo Fisher Scientific.
JUN 15, 2021
10:00 AM PDT
C.E. CREDITS
JUN 15, 2021
10:00 AM PDT
Date: June 15, 2021 Time: 10:00am (PDT), 1:00pm (EDT) SPRm (Surface Plasmon Resonance Microscopy) is a novel technology that enables label-free and real-time binding affinity and kinetics of...
Speaker:
Elaine Mai, MS
,
Shijie Wu, Ph.D
Sponsored By: Biosensing Instrument
-
LabRoots and the Cell Biology Planning Committee are pleased to announce the 6th Annual Cell Biology Virtual Event , providing an opportunity to discuss recent discoveries in biological rese...SEP 22, 2021 5:30 AM PDTC.E. CREDITS
SEP 22, 2021 5:30 AM PDTLabroots and the Cell Biology Planning Committee are pleased to announce the 5th Annual Cell Biology Virtual Event , providing an opportunity to...SEP 14, 2021 7:00 AM PDT
SEP 14, 2021 7:00 AM PDTWorking in Tandem : 1st annual TMT Symposia Tandem Mass Tags (TMT) are isobaric labels that allow for simultaneous identification and quantification of protein expression from multiple sampl...SEP 08, 2021 6:00 AM PDT
SEP 08, 2021 6:00 AM PDTLuminex's xMAP® Technology enables the evaluation of up to 500 analytes simultaneously in a single well, known as multiplexing. xMAP Technology uses color-coded microspheres as the substrate...JUL 22, 2021 8:00 AM EDTC.E. CREDITS
JUL 22, 2021 8:00 AM EDTGene and cell engineering advances have influenced almost all branches of life sciences. From the lab to the clinic, innovative gene synthesis technologies and gene editing tools have transf...
LabRoots and the Cell Biology Planning Committee are pleased to announce the 6th Annual Cell Biology Virtual Event , providing an opportunity to discuss recent discoveries in biological rese...
SEP 22, 2021
5:30 AM PDT
C.E. CREDITS
SEP 22, 2021
5:30 AM PDT
Labroots and the Cell Biology Planning Committee are pleased to announce the 5th Annual Cell Biology Virtual Event , providing an opportunity to...
SEP 14, 2021
7:00 AM PDT
SEP 14, 2021
7:00 AM PDT
Working in Tandem : 1st annual TMT Symposia Tandem Mass Tags (TMT) are isobaric labels that allow for simultaneous identification and quantification of protein expression from multiple sampl...
SEP 08, 2021
6:00 AM PDT
SEP 08, 2021
6:00 AM PDT
Luminex's xMAP® Technology enables the evaluation of up to 500 analytes simultaneously in a single well, known as multiplexing. xMAP Technology uses color-coded microspheres as the substrate...
JUL 22, 2021
8:00 AM EDT
C.E. CREDITS
JUL 22, 2021
8:00 AM EDT
Gene and cell engineering advances have influenced almost all branches of life sciences. From the lab to the clinic, innovative gene synthesis technologies and gene editing tools have transf...
C.E. CREDITS
Are you about to start designing your first cryo-electron microscopy (cryo-EM) experiment, or are you a seasoned cryo-EM pro looking for the latest news and advancements in life science rese...
Each step in a diagnostic test's journey-from raw material extraction to patient administration-can influence outcomes....
JUN 08, 2021
7:00 AM PDT
JUN 08, 2021
7:00 AM PDT
The global pandemic has not only changed our plans for how we live and work, but also accelerated the need for innovation to protect human health. Join us for an Innovation Summit to hear fi...
MAR 16, 2021
8:00 AM EDT
MAR 16, 2021
8:00 AM EDT
Join the two-Day Virtual IVD Conference on advancing immunoassay tech and performance Making an in vitro diagnostic assay has never been easy. Now with the global lab and supply chain and di...
- Cell
- Protein
- Research
- University
- Disease
- Research and Development
- Publishing
- Cancer
- Gene
- Health
- Headache
- Sleep
- Sleep Medicine
- Locomotion
- Teeth
- Molecular Genetics
- Medicinal Marijuana
- CB1 Receptor
- Cannabidiol
- Crystal Structure
- CB2 Receptor
- Medical Marijuana
- Protein Structure
- Cannabidiol (CBD)
- Phytochemistry
- Science
- Biology
- T-Cells
- Reproductiive Health
- Drug Development
- Clinical Medicine
- Cell Biology
- Wellness
- Functional Medicine
- Molecular Biology
- Sequencing
- Endocannabinoid System
- Therapy
- Protein Biochemistry
- Human Genetics
- Cannabinoid Research
- Mood
- Fat
- Laboratory
- Suicide
- Sleep Disorders
- Jupiter
- Technology
- GABA Receptors
- Zebrafish