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      • Applications of Metagenomic NGS in Immunodeficient Patients
        MAY 31, 2023
        Applications of Metagenomic NGS in Immunodeficient Patients
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        MAY 31, 2023
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        Current Landscape of Blood Culture Diagnostic Methods
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        Transforming Urine Culture Analysis with AI-Trained Imaging: A Deep Dive into BD Kiestra™ Lab Automation Imaging
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        MAY 25, 2023
        Evaluating MGUS with Free Light Chain Assays in Clinical Practice
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        MAY 24, 2023
        The Evolution of Precision Diagnostics in Advancing Treatment Strategies of Solid Tumors
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        MAY 23, 2023
        Facilitate Clone Selection with High-Throughput Glycan Profiling
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        MAY 23, 2023
        Implementation of Fourier Transform Infrared (FTIR) spectroscopy into hospital hygiene: from research to routine application
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        MAY 18, 2023
        AGBT 2023 Recorded Spotlight Talk: NextSeq 1000 and 2000 Product updates and key applications
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        Treponema screening: Challenges and Diagnostics Roadmap
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        Bacteria Have Had a Significant Impact on Insect Diversification
        Bacteria Have Had a Significant Impact on Insect Diversification
      • Gene Therapy Restores Hearing in a Mouse Model of Hearing Loss
        Gene Therapy Restores Hearing in a Mouse Model of Hearing Loss
        Gene Therapy Restores Hearing in a Mouse Model of Hearing Loss
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        Memorial Day and Cancer Risk Among US Veterans
        Memorial Day and Cancer Risk Among US Veterans
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        Running May Protect Against Memory Loss in Midlife
        Running May Protect Against Memory Loss in Midlife
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        Wireless Brain-Spine Interface Reverses Paralysis in 40-Year-Old Man
        Wireless Brain-Spine Interface Reverses Paralysis in 40-Year-Old Man
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        Nearly Half of All Species Are Declining - Mass Extinction Will Be Worse than Previously Thought
        Nearly Half of All Species Are Declining - Mass Extinction Will Be Worse than Previously Thought
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        Homo sapiens Arose From Multiple Lineages - Changing the Origin of Species
        Homo sapiens Arose From Multiple Lineages - Changing the Origin of Species
      • Copper in the Mitochondria Controls Inflammation
        Copper in the Mitochondria Controls Inflammation
        Copper in the Mitochondria Controls Inflammation
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        Sunscreen, Sunburn, & Skin Cancer
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        Vitamin K May Have a Central Role in Type 2 Diabetes
        Vitamin K May Have a Central Role in Type 2 Diabetes
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        Progress Towards Developing Therapies to Prevent Brain Metastases
        Progress Towards Developing Therapies to Prevent Brain Metastases
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        A Way to Identify Narcissists
        A Way to Identify Narcissists
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        The Next Gen of Venting Materials: Versapor® RC Membranes
        The Next Gen of Venting Materials: Versapor® RC Membranes
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        Automated Cell Selection and Retrieval Opens a Universe of Possibilities | eBook
        Automated Cell Selection and Retrieval Opens a Universe of Possibilities | eBook
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    Protein Binding

    Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.

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      FEB 15, 2023 | 7:00 AM
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      NOV 30, 2022 | 11:00 AM
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    Virtual Events

    • SEP 20, 2023  | 6:00 AM PDT
      Cell Biology Virtual Event Series 2023
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      SEP 18, 2024  | 6:00 AM PDT
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