OCT 05, 2016 4:00 PM PDT

"Water Scorpion" Flying Muscles Beat in Rhythm Like the Human Heart

WRITTEN BY: Kara Marker
Scientists reach roadblocks when they try to study diseases of the human heart merely because of its necessity for human life. In a new study from Florida State University, researchers turn to a giant flying water bug for answers. 
Lethocerus indicus | Image credit: www.biolib.cz
Lethocerus indicus, also known as the “water scorpion,” is native to South and Southeast Asia. It doesn’t have much in common with human physiology, except for the rhythmic movement of its flight muscles that resemble the beat of a human heart. 

Because of its muscular similarities, Florida State scientists used L. indicus to study how myosin and actin, the two filaments present in every muscle cell, interact to beat rhythmically. Inherited human mutations causing muscle diseases of the heart often stem from myosin rod mutations. While the researchers might not be able to study the myosin filaments of an actual human heart, they can learn about the same mechanisms where it’s present elsewhere in nature: via the flight mechanisms of L. indicus.

"We study insect flight muscle because it is a simpler route to understanding human disease," said Florida State professor Kenneth Taylor. "Ultimately, we must understand human disease from either human filaments or at least mammalian filaments."

Taylor and his team produced a three-dimensional electron microscope image of a tiny filament of an essential muscle belonging to L. indicus, which is made up of myosin and actin, just like the muscles of humans. The image is the first of its kind, showing the myosin filaments in a relaxed state, ready to re-extend.

The image taught the researchers how the molecular motors of myosin are ordered in a way to prevent contact with actin, which is responsible for re-extension of the muscle. "Many of these cardiomyopathy mutations may be understandable in terms of flawed muscle relaxation," Taylor said.

Next, Taylor and his team plan to work on enhancing the resolution of the electron microscope images in order to see “individual amino acids and accurately determine the key interactions between them.”

Taylor’s study was recently published in the journal Science Advances.
 


Sources: Florida State University, iNaturalist.org
 
About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
JAN 26, 2021
Genetics & Genomics
Why Only Some People With a Rare Mutation Get a Heart Condition
JAN 26, 2021
Why Only Some People With a Rare Mutation Get a Heart Condition
Scientists have found a way to explain why a heart condition called hypertrophic cardiomyopathy (HCM) can be so differen ...
FEB 09, 2021
Cardiology
Iron Levels as a Prognostic Indicator for Heart Failure
FEB 09, 2021
Iron Levels as a Prognostic Indicator for Heart Failure
When people think of iron, it usually brings up images of big hunks of metal. But did you know it is also essential for ...
MAR 01, 2021
Cardiology
How Heart Problems May Lead to Memory Deficits
MAR 01, 2021
How Heart Problems May Lead to Memory Deficits
Researchers have used a mouse model to show that heart problems can lead to disruptions in gene activity in the memory c ...
MAY 03, 2021
Cardiology
Task Force IDs 7 Costly Medical Procedures With No Benefit
MAY 03, 2021
Task Force IDs 7 Costly Medical Procedures With No Benefit
Researchers have identified a surprising number of health screens that are given to patients who may not need them. Thes ...
JUN 29, 2021
Immunology
The Heartbreaking Nature of COVID Revealed
JUN 29, 2021
The Heartbreaking Nature of COVID Revealed
Researchers at the Washington University School are getting to the root of heart damage resulting from COVID-19 infectio ...
JUL 11, 2021
Cannabis Sciences
How Does Cannabis Affect Birth Control?
JUL 11, 2021
How Does Cannabis Affect Birth Control?
According to the Centre for Disease Control and Prevention (CDC), between 2015 and 2017, 64.9% of women in the US w ...
Loading Comments...