MAR 10, 2017 12:14 PM PST

The Best Is Yet To Come for Heart Failure Treatments

WRITTEN BY: Kara Marker

A careful balance must be struck between various pathways in the body, or adverse cardiac events like heart attacks and strokes can occur, and diseases like heart failure can develop. University of Alberta scientists are in the business of studying this balance, and their recent discovery of a new molecule makes balancing ten times easier.

Nearly six million American adults have heart failure. Credit: Everyday Health

When an individual’s heart can no longer pump enough blood to adequately supply the body tissues with oxygenated blood, the condition is called heart failure. Early diagnosis and treatment gives heart failure patients the best chance at a longer, more fulfilling life, but even the most advanced treatments are focused on reducing symptoms and preventing progression, rather than a cure.

The discovery

The University of Alberta discovery is that of a molecule called angiotensin converting enzyme 2 (ACE2) which, as its name suggests, negatively alters a hormone called angiotensin. This hormone is part of a pathway called the renin-angiotensin system (RAS) that is activated during heart failure. So naturally, drugs targeting RAS are used to treat heart failure, and ACE2 could be the next molecule for development.

What does “RAS” have to do with heart failure?

RAS is a master regulator of several physiological activities, mainly keeping the sodium balance, regulating fluid volume, and managing blood pressure. The last activity is especially important for cardiovascular disease, but RAS is also activated in the kidneys and central nervous system. Thus, inhibitors of RAS are also used to treat kidney disease.

Researchers used a novel genetic mapping technology to observe how RAS is involved in both acute and chronic heart failure, including heart transplant patients with heart failure. As a negative regulator of angiotensin, ACE2 can be used to improve all types of heart failure situations.

New heart failure drugs

Based on their research, University of Alberta outlined the steps necessary to create a new drug based on recombinant human ACE2, and it is expected to be on the market within three to five years.

In addition to the new ACE2 drug, the same genetic mapping technology used in this study boosts the potential of individualized medicine for heart failure drugs, providing personalized options to patients on a case-by-case basis.

The recent study was published in Journal of the American College of Cardiology.

Sources: Comprehensive Physiology, American Heart Association, National Heart, Lung, and Blood Institute, University of Alberta Faculty of Medicine & Dentistry

About the Author
I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
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