JAN 16, 2018 06:23 AM PST

New Heart Attack Treatment: Human Cardiac Muscle Patches

WRITTEN BY: Kara Marker

A new treatment to be used in the wake of a heart attack is a little bit like putting a bandaid on a cut to prevent it from getting infected. From the University of Alabama at Birmingham, scientists work with a new post-heart attack therapeutic technique: human cardiac muscle patches.

The dishes on the rocker are growing large, human cardiac-muscle patches. This rocking at 45 rpm during growth greatly improves the maturation of cardiomyocyte cells. Credit: UAB

The patches are 1.57 by 0.70 inches in width and about the thickness of a dime. Combining heart muscle cells, endothelial cells, and smooth muscle cells, the patches are made from a lineage of human-induced pluripotent stem cells (hiSPCs).

hiSPCs come from cells that have been reprogrammed to revert back to their “embryonic-like” state that allows the cells to become any cell type. In the lab, hiSPCs can be induced to become whatever cell type needed by scientists for study or for therapeutic use. In the present study, researchers induced the hiSPCs to become the three cell types needed to create the new muscle patches.

Most importantly, the patches are grown in a three-dimensional fibrin matrix, a factor that separates them from past attempts by scientists to create a patch to repair heart muscle tissue. Compared to patches made from a single layer of cells, the new patches are capable of producing more heart muscle cells that are more mature and more powerful.

The patches also release exosomes, which transport proteins and RNA between cells and promote the survival of heart muscle cells.

In a new study with a pig model of heart attack, researchers used two patches to cover the dead heart muscle. This improved left ventricle function, the chamber of the heart responsible for pumping blood to all the body’s tissues. Plus, the experiment lacked a complication seen in similar studies from the past: arrhythmia as a result of patch transplantation.

Researchers also saw an improvement in the rate of engraftment compared to past attempts to use hiPSCs to treat heart attack in studies with similar animal bodies.

The present study was published in the journal Circulation.

Sources: BMC Biology, University of Alabama at Birmingham, UCLA Stem Cell Research

About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
MAY 25, 2018
Cardiology
MAY 25, 2018
CPAP Method Reduces The Incidence of Cardiovascular Disease
Despite being below Type 2 diabetes levels, blood glucose levels in individuals with prediabetes are higher than normal. Often times, as a result, these in...
JUN 29, 2018
Cardiology
JUN 29, 2018
The Drug That's Best for Both Kidney Failure and Arrhythmia Patients
A specific drug is the best to prescribe to people with both an irregular heartbeat and kidney failure. This population of people is at a particularly high...
AUG 05, 2018
Cardiology
AUG 05, 2018
Sauna's Bring Relaxation and Cardiovascular Health
Sauna's bring relaxation and pleasure, but also cardiovascular health benefits when used regularly....
AUG 09, 2018
Cardiology
AUG 09, 2018
GutHeart Links Microbes and Heart Failure
GutHeart seeks to link gut microbial communities with inflammatory and metabolic pathways in the cardiovascular system....
AUG 26, 2018
Cardiology
AUG 26, 2018
E-cigarette Use Doubles Risk of Heart Attack
Regular use of e-cigarettes shows similar risk of heart attack compared to conventional cigarettes, use of both doubles heart attack risk....
SEP 12, 2018
Cardiology
SEP 12, 2018
The Globalization of Heart Disease
In the science of cardiology, there is abundant evidence from high-tech, high-cost laboratory study that proves low-cost, low-tech lifestyle changes like d...
Loading Comments...