JAN 25, 2018 6:14 AM PST

The Surprising Role of Metabolism in Congestive Heart Failure

WRITTEN BY: Kara Marker

When the heart deviates from its normal source of energy, congestive heart failure can develop. From the German Cancer Research Center, scientists are showing the importance of metabolism in the science of heart failure.

Chest radiograph of an 83 year old man with previous coronary artery bypass surgery indicating intermediate congestive heart failure.

Healthy hearts use fatty acids for 75 percent of their energy source, but weak hearts switch to using carbohydrates as energy. In the new study, researchers discovered that, on its own, the shift from fatty acids to carbohydrates leads to congestive heart failure.

Congestive heart failure, also known as cardiac insufficiency, is characterized by the heart’s failure to pump enough blood throughout the body. Symptoms like shortness of breath, buildup of watery fluid, and “diminished exercise capacity” are seen, and the condition is eventually lethal.

Notch-1, a receptor molecule, is at the center of this study’s discovery. Notch-1 is responsible for ferrying fatty acids from the blood to the heart muscle, where they can be used as energy. Without Notch-1, another signaling pathway is activated: mTOR. This pathway triggers unhealthy growth of the heart muscle, further contributing to heart failure.

In their studies, scientists inactivated Notch-1 in mice and genetically modified mice to contain inactivated Notch-1 in cells lining the surface of the blood vessels. Both groups of mice developed heart failure.

"For nutrients to travel from the blood vessels into the heart muscle, they must be transported through the endothelial cells,” explained first author Markus Jabs. “With Notch-1 inhibited, the heart has less fatty acids available and it must shift to glucose as an energy source.”

While it may be possible to to counter the effects of metabolic shift from fatty acids to carbohydrates by blocking the mTOR signaling pathway or via a low-carb diet, team leader Andreas Fischer doesn’t suggest either actions as a solution to the problem illustrated by the findings in the new study.

"However, this does not mean that we should completely erase carbohydrates from our meal plan in order to prevent heart failure," Fischer said. "But our results show the immense impact that a change in metabolism, such as in inherited or acquired metabolic disorders, has on the course of congestive heart failure."

The present study was published in the journal Circulation.

Sources: MedlinePlus.gov, German Cancer Research Center

About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
FEB 24, 2021
Cardiology
Drinking Lots of Unfiltered Coffee May Raise Heart Disease Risk
FEB 24, 2021
Drinking Lots of Unfiltered Coffee May Raise Heart Disease Risk
While there has been a lot of debate about whether or not coffee is good for you, a new study reported in Clinical Nutri ...
MAR 25, 2021
Cardiology
Improved Triage Method to Get STEMI Patients from Door to Treatment
MAR 25, 2021
Improved Triage Method to Get STEMI Patients from Door to Treatment
A heart attack is an incredibly sudden and dangerous cardiac event that requires quick action for a successful recovery. ...
MAY 24, 2021
Cardiology
Heart Organoids with a Contracting Chamber are Created
MAY 24, 2021
Heart Organoids with a Contracting Chamber are Created
Scientists that study human disease have long had to rely on animal models or cell culture platforms in which cells grew ...
JUL 13, 2021
Health & Medicine
The Science of Crying
JUL 13, 2021
The Science of Crying
Crying: In humans, it's the production of tears usually accompanied by facial muscle contractions and vocal sounds. ...
JUL 27, 2021
Cardiology
Researchers Advise Those Considering Pregnancy to Check Heart Health
JUL 27, 2021
Researchers Advise Those Considering Pregnancy to Check Heart Health
Scientists have examined the associations between cardiovascular problems before a pregnancy and complications during la ...
SEP 08, 2021
Technology
Vaping Devices With Nicotine Increase the Frequency of Blood Clots
SEP 08, 2021
Vaping Devices With Nicotine Increase the Frequency of Blood Clots
The safety of e-cigarettes, or vaping devices, has been the topic of fierce debate recently. Some advocates suggest that ...
Loading Comments...