FEB 01, 2018 1:20 PM PST

Molecular "Nets" within the Heart Lead to Organ Failure

WRITTEN BY: Kara Marker

When clusters of a particular molecule form in the heart muscle tissue, the heart struggles to function normally. While scientists are used to seeing this occur in a rare genetic disease, a new study revealed that many people are affected by these clusters.

Chondroitin sulfate (marked in red), virtually absent in healthy human heart tissue (right panel), is found to accumulate in hearts of patients with heart failure, forming dense 'molecular nets' around the heart muscle cells (left panel). Credit: NUHS

From the National University Health System in Singapore, scientists are investigating accumulation of chondroitin sulfate in the heart muscle. Chondroitin sulfate is a type of molecule usually only found in cartilage and other connective tissues; it is made up by many sugar molecule bound together in a long chain. This finding was surprising, as accumulation of chondroitin sulfate in the heart normally occurs only during a rare condition called mucopolysaccharidosis (MPS) type VI.

MPS type VI, also known as Maroteaux-Lamy syndrome is a rare, progressive disease that often results in skeletal abnormalities. For individuals born with this disease, symptoms first appear usually during early childhood, ranging from an abnormally large head, fluid buildup in the brain, coarse facial features, and a large tongue. While other type of MPS affect intelligence, type VI does not.

The life expectancy of someone born with MPS type VI depends on the severity of an individual’s symptoms, but treatment is vital for those affected to survive past late childhood. When a person with MPS type VI does die, heart disease from chondroitin sulfate accumulation or airway obstruction are usually the cause.

After finding the clusters of chondroitin sulfate (called molecular “nets” because of the way this molecule binds to other proteins) in the hearts of individuals without MPS type VI, researchers realized that this could be another factor contributing to inflammation in the heart that often leads to or exacerbates existing heart failure.

“Heart failure patients without MPS VI also have molecular nets, which can be targeted with a medicine that is already U.S. FDA-approved,” explained lead author Roger Foo. “Targeting these molecular nets may bring a fresh new treatment approach for patients with this severe debilitating disease.”

The FDA-approved drugs Foo mentions are those like beta-blockers and ACE-inhibitors, which are commonly prescribed to treat heart disease. For individuals without MPS type VI but still have molecular nets in the heart, treatment with a drug used to treat MPS type VI, called arylsulfatase B (ASB) enzyme, could clear the accumulation of chondroitin sulfate.

Scientists have successfully done so only in animal models, but clinical trials with humans could be put into motion soon. By adding ASB enzyme to the regimen of drugs people with heart failure already take, researchers could decrease the chance of heart disease transitioning into heart failure.

The present study was published in the journal Circulation.

Sources: Genetics Home Reference, National University Health System

About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
OCT 13, 2020
Cardiology
A Kidney Toxin Could Act as a Biomarker for Cardiovascular Risk
OCT 13, 2020
A Kidney Toxin Could Act as a Biomarker for Cardiovascular Risk
Biomarkers have taken the diagnostic field by storm over the past decade. The search for stable, easy to access indicato ...
OCT 15, 2020
Cardiology
Measuring Pulse Transit Time as a Replacement for the Inflatable Cuff
OCT 15, 2020
Measuring Pulse Transit Time as a Replacement for the Inflatable Cuff
Many people deal with one disease or another every day of their life. Most require checking on things like blood sugar f ...
DEC 10, 2020
Cardiology
CircRNAs as Prognostic Indicators for Atrial Fibrillation
DEC 10, 2020
CircRNAs as Prognostic Indicators for Atrial Fibrillation
The use of genetics in therapies and diagnostics has boomed over the decades. While many of these breakthroughs focus on ...
DEC 11, 2020
Cell & Molecular Biology
E-Cigarette Flavors Damage Heart Cells
DEC 11, 2020
E-Cigarette Flavors Damage Heart Cells
E-cigarettes or vapes were introduced a few years ago, and researchers are still trying to learn more about how they aff ...
DEC 29, 2020
Cardiology
Does Physical Activity Help Reduce the Risk of Aneurysms?
DEC 29, 2020
Does Physical Activity Help Reduce the Risk of Aneurysms?
An active lifestyle is a proven way to prevent many types of cardiovascular diseases. The increased blood flow can preve ...
APR 27, 2021
Cardiology
Excess Belly Weight Raises Heart Disease Risk Regardless of BMI
APR 27, 2021
Excess Belly Weight Raises Heart Disease Risk Regardless of BMI
Research has suggested that excess weight around the midsection of a person's body is a much better predictor of poor he ...
Loading Comments...