FEB 01, 2018 1:06 PM PST

Brain Pacemaker in Frontal Lobe Slows Alzheimer's in New Study

WRITTEN BY: Julia Travers

In an Ohio State University study, patients with Alzheimer’s disease showed promising responses to a deep-brain-stimulation (DBS) device, sometimes called a “brain pacemaker,” that was implanted in their frontal lobe. The three subjects experienced a slowing down of the decline in their executive functioning and daily life-skills, compared to others with similar disease progression who did not have the device. While DBS has previously been tested with Alzheimer’s patients specifically to improve their memory, this is the first time it has been used in an effort to boost executive function.

X-ray of DBS patient, credit: Ohio State University Wexner Medical Center

Executive brain functions include sustaining attention, solving problems, making plans and forming judgements. These skills are needed to perform daily self-care tasks and participate in social interactions. Alzheimer’s patients typically experience a decline in these functions along with significant memory loss. In an effort to stimulate the frontal lobe, which is associated with these mental abilities, the DBS device was implanted into an area of the lobe known as the ventral striatum. The “brain pacemaker” is made of thin wires and a battery that can send electrical impulses into the brain.

"We have many memory aids, tools and pharmaceutical treatments to help Alzheimer's patients with memory, but we don't have anything to help with improving their judgments, making good decisions, or increasing their ability to selectively focus attention on the task at hand and avoid distractions," Co-author Dr. Douglas Scharre, director of the Division of Cognitive Neurology at Ohio State's Wexner Medical Center's Neurological Institute, said. He added that these executive functions are essential to routine activities such as selecting meals, cleaning up a home or spending time with loved ones.

The three patients in the study were given DBS for a minimum of 18 months. They were repeatedly given cognitive function tests at set intervals. These DBS participants were found to show less of a decline in their scores than about 100 individuals of similar age who were also experiencing impairment from Alzheimer’s and who didn’t have DBS.

All three patients showed a lower level of cognitive decline. They also completed the study “without significant adverse effects,” the abstract explains. Two of the subjects showed a significantly and “meaningfully” lower rate of decline in cognitive function. One 85-year-old even showed an improvement in daily life skills and decision making ability; she was able to progress from not cooking for herself to making her own simple meals.

Because this was such a small study, it should now be run with larger groups, Neurosurgeon Michael Schulder of North Shore University Hospital, who was not involved with this research, said. He explained that DBS, which has also been used to treat other neurological conditions, works in somewhat mysterious and unknown ways – it may help brain cells function or block signals that keep them from working normally.

“Frontal network modulation to improve executive and behavioral deficits should be furthered studied in [Alzheimer’s disease],” the study’s authors conclude.

 “Deep Brain Stimulation of Frontal Lobe Networks to Treat Alzheimer’s Disease,” was published in the Journal of Alzheimer's Disease Jan. 30, 2018.

About the Author
Julia Travers is a writer, artist and teacher. She frequently covers science, tech, conservation and the arts. She enjoys solutions journalism. Find more of her work at jtravers.journoportfolio.com.
You May Also Like
OCT 25, 2022
Earth & The Environment
US Economy Might Not Be Able to Recoup Future Hurricane Economic Impacts
OCT 25, 2022
US Economy Might Not Be Able to Recoup Future Hurricane Economic Impacts
In a recent study published in Environmental Research Letters, an international team of researchers led by the Potsdam I ...
OCT 27, 2022
Space & Astronomy
Star Remains Coughed Up by Black Hole
OCT 27, 2022
Star Remains Coughed Up by Black Hole
In a recent study published in The Astrophysical Journal, an international team of researchers led by the Center for Ast ...
NOV 07, 2022
Technology
Scientists Examine Human-Machine Workplace Relationship
NOV 07, 2022
Scientists Examine Human-Machine Workplace Relationship
In a recent study published in Applied Ergonomics, a team of researchers from Texas A&M University (TAMU) examined t ...
NOV 10, 2022
Space & Astronomy
Hey Star, Want to Look Younger? Get Yourself a Hot Jupiter!
NOV 10, 2022
Hey Star, Want to Look Younger? Get Yourself a Hot Jupiter!
A new study published in the Monthly Notices of the Royal Astronomical Society finds that “hot Jupiter” exop ...
NOV 15, 2022
Earth & The Environment
The Life of Her Mind Episode 3: Dr. Kisha Supernant
NOV 15, 2022
The Life of Her Mind Episode 3: Dr. Kisha Supernant
  Dr. Kisha Supernant (Métis/Papaschase/British), Associate Professor at the University of Alberta, is a gro ...
DEC 05, 2022
Neuroscience
Laser Treatment May Improve Short Term Memory
DEC 05, 2022
Laser Treatment May Improve Short Term Memory
Drugs that effectively treat disorders of the brain are very challenging to develop. In the past few decades, researcher ...
Loading Comments...