MAR 13, 2018 3:54 AM PDT

Directly Reversing the Effects of Common Anticoagulants

WRITTEN BY: Kara Marker

For people at a high risk of developing blood clots, a prescription for a type of drug called an anticoagulant is vital. But with a particular type of anticoagulant called Factor Xa inhibitors, excessive bleeding is also a risk. Scientists from McMaster University in Canada now introduce andexanet, an experimental drug that, if approved by the FDA, could be the first drug available to treat excessive bleeding for Factor Xa inhibitor patients.

A scanning electron micrograph depicted a number of red blood cells found clotted together.

Experts estimate that almost three million people in the United States currently take Factor Xa inhibitors, often older people who are at high risk for stroke and venous thrombosis due to heart failure or other problems. Anticoagulants like Factor Xa inhibitors reduce the body’s ability to form a blood clot, which is good for preventing stroke but bad in cases of uncontrolled bleeding. Andexanet’s role would come into play when patients taking Factor Xa inhibitors experience major bleeding, as the drug can directly counter the effects of the anticoagulant.

About 84,000 people taking Factor Xa inhibitors are hospitalized for major bleeding each year, often due to brain bleeding, a fall, or gastrointestinal bleeding. A quarter of all people taking Factor Xa inhibitors die when bleeding in the brain occurs. Andexanet could be the reversal agent responsible for preventing those deaths.

"Factor Xa inhibitors are already widely used because of their excellent efficacy and safety profile. However, some physicians and patients may choose to use other anticoagulant drugs because they have a reversal agent rather than using one of the Factor Xa inhibitors,” explained lead author Stuart Connolly, MD. “Having a safe and effective reversal agent available will benefit patients with acute bleeding."

Andexanet works by allowing Factor Xa, a blood coagulation factor, do its job: clot the blood. In preliminary studies with healthy patients, researchers showed that andexanet successfully reversed the anti-clotting effect of Factor Xa inhibitors, with no significant negative side effects.

Now researchers are working on a clinical trial called AMNEXA-4, recruiting patients having trouble with major bleeding as a result of taking Factor Xa inhibitors. Researchers are testing the drug for both safety and effectiveness, and so far the drug appears to be working well.

"This study is only focused on patients who are acutely bleeding, but there is also great interest in using a drug like andexanet for patients who come into a medical center on a Factor Xa inhibitor and require urgent surgery," Connolly said. "We hope to study that patient population in the future."

Sources: American College of Cardiology, Vascular Health and Risk Management, Expert Opinion on Therapeutic Targets

About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
JUL 03, 2020
Cardiology
How Diet and Gut Microbes May Impact Artery Health
JUL 03, 2020
How Diet and Gut Microbes May Impact Artery Health
Researchers are learning how dietary choices may be causing damage to the arteries as people age.
AUG 06, 2020
Cardiology
Identifying a Prognostic Biomarker for Neurological Deterioration After a Stroke
AUG 06, 2020
Identifying a Prognostic Biomarker for Neurological Deterioration After a Stroke
Strokes are life-changing events that can cause a myriad of issues even after it is over. Plenty of tests, such as the n ...
SEP 05, 2020
Cardiology
Psoriasis and Hyperlipidemia May Put You at Risk for Chronic Kidney Disease
SEP 05, 2020
Psoriasis and Hyperlipidemia May Put You at Risk for Chronic Kidney Disease
The sad truth is that many diseases not only carry their own symptoms but can also increase the risk of the onset of ano ...
SEP 16, 2020
Neuroscience
Blood Lipid Levels Predict Depression and Anxiety
SEP 16, 2020
Blood Lipid Levels Predict Depression and Anxiety
While people often experience anxiety and depression together, psychiatrists classify them as different disorders. And n ...
SEP 16, 2020
Cardiology
Stem Cells Can Generate a 3D Mini-Model of the Heart
SEP 16, 2020
Stem Cells Can Generate a 3D Mini-Model of the Heart
The heart is a special organ, and while we know a lot about how it develops, there are still mysteries.
NOV 16, 2020
Cardiology
High Doses of Fish Oil Don't Reduce Risk of Cardiac Events
NOV 16, 2020
High Doses of Fish Oil Don't Reduce Risk of Cardiac Events
Many people take fish oil supplements to try to improve various aspects of their health, but new work from the Cleveland ...
Loading Comments...