MAR 16, 2018 09:36 AM PDT

Four RNA Molecules that Predict an Irregular Heartbeat

WRITTEN BY: Kara Marker

Atrial fibrillation (AF), an irregular heartbeat, often goes unnoticed until the affected person has a stroke. Scientists are interested in identifying a better way to detect AF so they can help prevent stroke and other consequences of this condition. A new discovery from Tokyo Medical and Dental University offers a solution.

Artistic rendering of atrial fibrillation. Credit: Bruce Blaus

In their new study, Tokyo Medical and Dental University researchers identified four novel microRNA (miRNA) molecules in the bloodstream that are potentially predictive of AF, an irregular heartbeat that can lead to blood clots, stroke, heart failure, and other heart problems. As AF develops, the upper chambers of the heart beat irregularly as they pump blood into the lower chambers.

Nearly three million Americans are affected by AF, and 15 to 20 percent of people with strokes also have AF. Treatment includes controlling the heart’s rhythm and the heart rate, preventing blood clots, and managing risk factors for stroke: aging, high blood pressure, diabetes, smoking, obesity, and more. AF often goes undetected until a person has a stroke.

Scientists began their study knowing the miRNAs had been associated with the development of AF before, but no one could explain the link. miRNAs are small, non-coding RNA molecules that regulate gene expression after transcription. They were originally discovered in the 90s and are found in most eukaryotes. miRNAs account for up to five percent of the human genome and regulate at least 30 percent of all protein-coding genes. They were thought to be potential biomarkers for heart disease because of their stability in the bloodstream.

To find out if miRNAs could be a reliable biomarker for AF, researchers conducted a comparison of miRNA expression in AF patients and healthy individuals, as well as between control mice and mice with an irregular heartbeat similar to human AF. Human and mice samples were tested for 733 and 672 miRNAs respectively.

Researchers successfully identified four unique miRNAs that were significantly upregulated in the serum of AF patients and mice with an irregular heartbeat. They want to conduct further studies to elucidate the relationship between miRNAs and AF.

"The same two miRNAs showed increased expression in a subset of patients with intermittent AF and another subset with chronic AF," explained corresponding author Tetsuo Sasano. "The increases were in comparison both with healthy controls of the same age and young healthy controls, suggesting these miRNAs may predict AF regardless of the age of the individual."

The present study was published in the Circulation Journal.

Sources: American Heart Association, Current Genomics, Tokyo Medical and Dental University

About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
AUG 05, 2018
Cardiology
AUG 05, 2018
Sauna's Bring Relaxation and Cardiovascular Health
Sauna's bring relaxation and pleasure, but also cardiovascular health benefits when used regularly....
AUG 06, 2018
Cardiology
AUG 06, 2018
Changes in Heart Structure Linked to Air Pollution
Low levels of air pollution can cause heart remodeling similar to early stages of heart failure....
AUG 16, 2018
Cardiology
AUG 16, 2018
Get Physical for Heart Health
Increasing physical activity past age 60 can help lower the risk of cardiovascular disease and increase cardiovascular health....
AUG 30, 2018
Videos
AUG 30, 2018
Is Coconut Oil Really All That?
Much like kale, the often praised superfood of the veggie world, coconut oil has been appreciated for its health benefits and nutritional value. Used in ev...
SEP 06, 2018
Cardiology
SEP 06, 2018
Helping patients breathe normally again post heart failure.
One of the most common complaints from those recovering from heart failure (HF) is shortness of breath or dyspnea. This difficulty breathing is often viewe...
OCT 19, 2018
Cardiology
OCT 19, 2018
Transplant Options In The Face Of Shortage
Calling the shortage of organs available for transplant anything less than a crisis would unfairly downplay the issue. Someone is added to the national wai...
Loading Comments...