SEP 17, 2015 01:30 PM PDT

Life Begins With an Egg and a Sperm Cell...Then What?

WRITTEN BY: Sarah Hertrich
1 16 3245
Due to a lack in the development of reliable experimental systems for studying human embryos, there is currently not much known about the development of human germ cells. A germ cell is a type of cell that gives rise to an organism which is able to reproduce sexually. Once the egg and the sperm cell come together to form a reproductive cell, they are then called a gamete. A gamete is a haploid cell, meaning it contains a single set of 23 chromosomes containing human DNA. In the very beginning stages of germ cell development abnormalities within the germline can occur, giving rise to a variety of critical conditions including infertility, impaired development, as well as genetic and epigenetic disorders.
Because of the limitations in access to relevant materials as well as the controversy surrounding human stem cell research, there is a critical lack of information surrounding the mechanisms for germ cell development in humans.
Researchers at Kyoto University have sought out to determine the cause of these abnormalities through the development of a human germ cell model. What we currently know about germ cell development is due to research performed using a mouse model organism. While using this model has provided a great deal of valuable information, there are significant differences in the precise mechanisms for germ cell development among mammalian species. Because of the limitations in access to relevant materials as well as the controversy surrounding human stem cell research, there is a critical lack of information surrounding the mechanisms for germ cell development in humans.

In their study, researchers from Kyoto University explored the possibility of using a mouse germline to induce a human germ cellfate for the study of early human germ cell development. Through the development of this laboratory human germ cell line model, the research team was able to illustrate the transcription interactions and signaling events that occur during stem cell development. More importantly they were able to determine that epigenetic marks are “erased” at the beginning of germ cell development.

Through this research, the team hopes to be able to uncover the underlying mechanisms for conditions such as infertility.  Although the human germ cell line model is still in its early stages, their goal is to discover the mechanism throughout the entire developmental process from the embryo to adult. With the use of this model it may also possible to uncover the cause of newly identified epigenetic disorders, such as autism. It is expected that the impact of this research will be vast.

Source: MedicineNet; Cell Stem Cell; ScienceDaily
 
About the Author
  • I am a postdoctoral researcher with interests in pre-harvest microbial food safety, nonthermal food processing technologies, zoonotic pathogens, and plant-microbe interactions. My current research projects involve the optimization of novel food processing technologies to reduce the number of foodborne pathogens on fresh produce. I am a food geek!
You May Also Like
JUN 12, 2018
Cancer
JUN 12, 2018
CD44 Insights & Cancer Influence
CD44 is a known cell surface protein involved in numerous interactions; it is overexpressed in cancerous tissue and its isoforms are being investigated as targets for cancer immunotherapy
JUL 03, 2018
Clinical & Molecular DX
JUL 03, 2018
Blood Test Deciphers Your Internal Rhythm
A personalized reading of your circadian rhythm could help scientists prescribe the exact time of day that drug treatments will be the most effective. A ne
JUL 09, 2018
Cell & Molecular Biology
JUL 09, 2018
Scientists Found a New Way to Treat Lung Cancer
Small cell lung cancer is an aggressive type that can be fatal; there were few treatments for the disease. That may have changed.
AUG 04, 2018
Cell & Molecular Biology
AUG 04, 2018
Bioengineered Lung Successfully Grown and Transplanted
The complexity of human organs has made them difficult to engineer, but real progress is being made.
AUG 05, 2018
Cell & Molecular Biology
AUG 05, 2018
The Major Health Risks Posed by Cipro
In recent years, studies have shown that a once-popular class of antibiotics can have life-threatening side effects.
AUG 13, 2018
Genetics & Genomics
AUG 13, 2018
Heritable and Environmental Factors Influence Gene Activity
Even if something gets described as epigenetic, it does not necessarily mean it's an environmental effect.
Loading Comments...