SEP 17, 2015 01:30 PM PDT

Life Begins With an Egg and a Sperm Cell...Then What?

Due to a lack in the development of reliable experimental systems for studying human embryos, there is currently not much known about the development of human germ cells. A germ cell is a type of cell that gives rise to an organism which is able to reproduce sexually. Once the egg and the sperm cell come together to form a reproductive cell, they are then called a gamete. A gamete is a haploid cell, meaning it contains a single set of 23 chromosomes containing human DNA. In the very beginning stages of germ cell development abnormalities within the germline can occur, giving rise to a variety of critical conditions including infertility, impaired development, as well as genetic and epigenetic disorders.
Because of the limitations in access to relevant materials as well as the controversy surrounding human stem cell research, there is a critical lack of information surrounding the mechanisms for germ cell development in humans.
Researchers at Kyoto University have sought out to determine the cause of these abnormalities through the development of a human germ cell model. What we currently know about germ cell development is due to research performed using a mouse model organism. While using this model has provided a great deal of valuable information, there are significant differences in the precise mechanisms for germ cell development among mammalian species. Because of the limitations in access to relevant materials as well as the controversy surrounding human stem cell research, there is a critical lack of information surrounding the mechanisms for germ cell development in humans.

In their study, researchers from Kyoto University explored the possibility of using a mouse germline to induce a human germ cellfate for the study of early human germ cell development. Through the development of this laboratory human germ cell line model, the research team was able to illustrate the transcription interactions and signaling events that occur during stem cell development. More importantly they were able to determine that epigenetic marks are “erased” at the beginning of germ cell development.

Through this research, the team hopes to be able to uncover the underlying mechanisms for conditions such as infertility.  Although the human germ cell line model is still in its early stages, their goal is to discover the mechanism throughout the entire developmental process from the embryo to adult. With the use of this model it may also possible to uncover the cause of newly identified epigenetic disorders, such as autism. It is expected that the impact of this research will be vast.

Source: MedicineNet; Cell Stem Cell; ScienceDaily
 
About the Author
  • I am a postdoctoral researcher with interests in pre-harvest microbial food safety, nonthermal food processing technologies, zoonotic pathogens, and plant-microbe interactions. My current research projects involve the optimization of novel food processing technologies to reduce the number of foodborne pathogens on fresh produce. I am a food geek!
You May Also Like
NOV 26, 2018
Neuroscience
NOV 26, 2018
Most Rewarding Experiences Take The Top Spot In Memory
brain filters out neutral, inconsequential events, retaining only the memories that are useful to the future decisions....
DEC 19, 2018
Cell & Molecular Biology
DEC 19, 2018
Better Security Through Biological Encryption
Securing information is a difficult prospect as computers become more powerful. Engineers have turned to biology....
DEC 27, 2018
Microbiology
DEC 27, 2018
Reputed Medicinal Soil Yields a Superbug-killing Bacterium
It's no secret that antibiotic resistance is a problem that already poses a serious threat to public health, and it's expected to get worse....
JAN 03, 2019
Microbiology
JAN 03, 2019
Genetic Risk Factors Make Some People Susceptible to Common Microbes
Th mycobacteria family of microbes includes over 70 members, which are everywhere and are often harmless. But they make some people sick....
JAN 04, 2019
Cell & Molecular Biology
JAN 04, 2019
With MIT's New Tool, Anyone Can Design DNA
Scientists at MIT and Arizona State University created a program that enables users to transform a drawing into a DNA structure....
JAN 15, 2019
Immunology
JAN 15, 2019
Unconventional T Cells
Spondyloarthritis is one of the most common types of chronic joint inflammation affecting nearly 1-2 percent of the Western population. Scientists report that rare populations of unconvention...
Loading Comments...