SEP 17, 2015 1:30 PM PDT

Life Begins With an Egg and a Sperm Cell...Then What?

WRITTEN BY: Sarah Hertrich
Due to a lack in the development of reliable experimental systems for studying human embryos, there is currently not much known about the development of human germ cells. A germ cell is a type of cell that gives rise to an organism which is able to reproduce sexually. Once the egg and the sperm cell come together to form a reproductive cell, they are then called a gamete. A gamete is a haploid cell, meaning it contains a single set of 23 chromosomes containing human DNA. In the very beginning stages of germ cell development abnormalities within the germline can occur, giving rise to a variety of critical conditions including infertility, impaired development, as well as genetic and epigenetic disorders.
Because of the limitations in access to relevant materials as well as the controversy surrounding human stem cell research, there is a critical lack of information surrounding the mechanisms for germ cell development in humans.
Researchers at Kyoto University have sought out to determine the cause of these abnormalities through the development of a human germ cell model. What we currently know about germ cell development is due to research performed using a mouse model organism. While using this model has provided a great deal of valuable information, there are significant differences in the precise mechanisms for germ cell development among mammalian species. Because of the limitations in access to relevant materials as well as the controversy surrounding human stem cell research, there is a critical lack of information surrounding the mechanisms for germ cell development in humans.

In their study, researchers from Kyoto University explored the possibility of using a mouse germline to induce a human germ cellfate for the study of early human germ cell development. Through the development of this laboratory human germ cell line model, the research team was able to illustrate the transcription interactions and signaling events that occur during stem cell development. More importantly they were able to determine that epigenetic marks are “erased” at the beginning of germ cell development.

Through this research, the team hopes to be able to uncover the underlying mechanisms for conditions such as infertility.  Although the human germ cell line model is still in its early stages, their goal is to discover the mechanism throughout the entire developmental process from the embryo to adult. With the use of this model it may also possible to uncover the cause of newly identified epigenetic disorders, such as autism. It is expected that the impact of this research will be vast.

Source: MedicineNet; Cell Stem Cell; ScienceDaily
 
About the Author
  • I am a postdoctoral researcher with interests in pre-harvest microbial food safety, nonthermal food processing technologies, zoonotic pathogens, and plant-microbe interactions. My current research projects involve the optimization of novel food processing technologies to reduce the number of foodborne pathogens on fresh produce. I am a food geek!
You May Also Like
DEC 23, 2019
Genetics & Genomics
DEC 23, 2019
A New Type of Muscle Cell That Could be a Target for Gene Therapy is ID'ed
Muscles have a supply of restorative stem cells called satellite cells, and now they have identified a new type....
JAN 11, 2020
Cell & Molecular Biology
JAN 11, 2020
To Save Others, Bacteria Can Self-Destruct When Infected by a Virus
Scientists were studying viruses that infect and kill bacteria as a medicine for bacterial infections over a hundred years ago, and they are a focus of recent research as well....
JAN 15, 2020
Microbiology
JAN 15, 2020
Scientists Engineer a New Kind of Life Form
Usig cells harvested from frogs, researchers created tiny robots....
JAN 20, 2020
Neuroscience
JAN 20, 2020
Ovarian Cancer Protein Accelerates Alzheimer's Neurodegeneration
Around 21,000 people in the US are diagnosed with ovarian cancer every year, while an estimated 5.8 million Americans have Alzheimer’s. Now, research...
FEB 04, 2020
Immunology
FEB 04, 2020
The Gut Deploys Protective Mechanisms in Coordination with Your Mealtime Habits
At mealtime, every mouthful of food contains a possible risk of incoming pathogens to the digestive system. The gut takes protective measures to account fo...
FEB 18, 2020
Cell & Molecular Biology
FEB 18, 2020
How Too Much Fluoride Can Disrupt Tooth Enamel
You can have too much of a good thing....
Loading Comments...