OCT 07, 2016 9:02 PM PDT

Some Cancer Cells Have Amyloids like Alzheimer's

WRITTEN BY: Carmen Leitch
Researchers have discovered that some proteins that have an influence on the progression and metastasis of cancer are stored away inside of dormant cancer cells, like amyloid bodies that are seen in some neurological disorders. When the amyloid bodies break up, the cell wakes up and is active again. Investigators at the Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have published these findings in Developmental Cell.
 
This is a high magnification of a nucleus with amyloid plaques (red: congo red staining). / Credit: Sylvester Comprehensive Cancer Center
 
Amyloid bodies are groups of proteins that form into aggregates of fine fibers that coalesce as sheets. Amyloids are known to play a part in the development of several neurological diseases like Alzheimer's and Parkinson's disease. Their exact role is still unknown, however. This work may indicate a new avenue for the development of therapeutics for some kinds of cancer.
 
"The amyloid state of protein organization is typically associated with debilitating human neuropathies and rarely observed in physiology," said the corresponding author of the study, Stephen Lee, the Director of the Tumor Biology Program at Sylvester, and a Professor of Biochemistry and Molecular Biology at the Miller School. "Yet, we found that a large number of proteins are stored as amyloid bodies in cancer cells that are dormant. The heat shock chaperone pathway can disaggregate the amyloid bodies and turn the dormant cancer cells into active, progressing cancer cells."
 
This is an electron microscopy of a cellular amyloid plaque. / Credit: Sylvester Comprehensive Cancer Center
 
Long intergenic non-coding RNAs (lincRNAs) are a relatively new class of regulatory molecule with poorly understood functions. The researchers determined that lincRNA regulates the formation of amyloids in cancer cells, and as such it’s a prime target for drug development.
 
"If we can stop the amyloid bodies from disaggregating in cancer cells, the hope is that they will remain dormant indefinitely," explained Lee. "In addition, we may also be able to turn active cancer cells into dormant ones by encouraging them to store the proteins as amyloid bodies."
 
The creation of amyloids allows cells to survive during prolonged periods of extracellular stress, suggesting there is amyloids have a protective function; they may not always be toxic to cells, and that is not restricted to cancer cells.
 
"Following this approach, we wouldn't necessarily rid the body of cancer cells, but we would keep them inactive - shut off, if you will - and not allow them to become active again," said Lee. "I am optimistic this could become a novel way of treating cancer. There are already drugs on the market, and others are being studied, that target the ribosomal intergenic noncoding RNA as well as the heat shock chaperone pathway."
 
For more information on long non-coding RNAs, watch the video below from Genetics Professor Ahmad Khalil.
 
 

Sources: Eurekalert!/AAAS, via University of Miami, Developmental Cell
 
About the Author
BS
Experienced research scientist and technical expert with authorships on over 30 peer-reviewed publications, traveler to over 70 countries, published photographer and internationally-exhibited painter, volunteer trained in disaster-response, CPR and DV counseling.
You May Also Like
SEP 29, 2022
Cell & Molecular Biology
What's In a Lysosome?
SEP 29, 2022
What's In a Lysosome?
The lysosome is a small membrane bound organelle that can be found in most animal cells. It was once thought that these ...
OCT 02, 2022
Cell & Molecular Biology
In Some Animals, Early Movements Can Have a Big Impact
OCT 02, 2022
In Some Animals, Early Movements Can Have a Big Impact
The Ikmi group at EMBL has shown that exercise has an important influence on the sea anemone.
OCT 05, 2022
Health & Medicine
SARS-CoV-2 Infects Cells in the Brain & May Cause Structural Changes
OCT 05, 2022
SARS-CoV-2 Infects Cells in the Brain & May Cause Structural Changes
Researchers have now published a study that has revealed how SARS-CoV-2, the virus that causes COVID-19, can infect brai ...
OCT 31, 2022
Cardiology
Why Heart Disease Is on the Radar With Cystic Fibrosis
OCT 31, 2022
Why Heart Disease Is on the Radar With Cystic Fibrosis
Cystic Fibrosis (CF) impacts roughly 35,000 people in the United States. CF results in a mutated form of the cystic fibr ...
NOV 08, 2022
Drug Discovery & Development
Blood Pressure Drug May Reduce Alzheimer's Risk in Black People
NOV 08, 2022
Blood Pressure Drug May Reduce Alzheimer's Risk in Black People
Telmisartan, a blood pressure-lowering medication, may help prevent or treat Alzheimer's disease (AD) in Black indiv ...
NOV 29, 2022
Cell & Molecular Biology
How a Master Regulator May be Working to Protect Cancer
NOV 29, 2022
How a Master Regulator May be Working to Protect Cancer
Scientists have now discovered yet another way that MYC proteins can promote cancer. MYC has been called a master regula ...
Loading Comments...