OCT 07, 2016 9:02 PM PDT

Some Cancer Cells Have Amyloids like Alzheimer's

WRITTEN BY: Carmen Leitch
Researchers have discovered that some proteins that have an influence on the progression and metastasis of cancer are stored away inside of dormant cancer cells, like amyloid bodies that are seen in some neurological disorders. When the amyloid bodies break up, the cell wakes up and is active again. Investigators at the Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have published these findings in Developmental Cell.
 
This is a high magnification of a nucleus with amyloid plaques (red: congo red staining). / Credit: Sylvester Comprehensive Cancer Center
 
Amyloid bodies are groups of proteins that form into aggregates of fine fibers that coalesce as sheets. Amyloids are known to play a part in the development of several neurological diseases like Alzheimer's and Parkinson's disease. Their exact role is still unknown, however. This work may indicate a new avenue for the development of therapeutics for some kinds of cancer.
 
"The amyloid state of protein organization is typically associated with debilitating human neuropathies and rarely observed in physiology," said the corresponding author of the study, Stephen Lee, the Director of the Tumor Biology Program at Sylvester, and a Professor of Biochemistry and Molecular Biology at the Miller School. "Yet, we found that a large number of proteins are stored as amyloid bodies in cancer cells that are dormant. The heat shock chaperone pathway can disaggregate the amyloid bodies and turn the dormant cancer cells into active, progressing cancer cells."
 
This is an electron microscopy of a cellular amyloid plaque. / Credit: Sylvester Comprehensive Cancer Center
 
Long intergenic non-coding RNAs (lincRNAs) are a relatively new class of regulatory molecule with poorly understood functions. The researchers determined that lincRNA regulates the formation of amyloids in cancer cells, and as such it’s a prime target for drug development.
 
"If we can stop the amyloid bodies from disaggregating in cancer cells, the hope is that they will remain dormant indefinitely," explained Lee. "In addition, we may also be able to turn active cancer cells into dormant ones by encouraging them to store the proteins as amyloid bodies."
 
The creation of amyloids allows cells to survive during prolonged periods of extracellular stress, suggesting there is amyloids have a protective function; they may not always be toxic to cells, and that is not restricted to cancer cells.
 
"Following this approach, we wouldn't necessarily rid the body of cancer cells, but we would keep them inactive - shut off, if you will - and not allow them to become active again," said Lee. "I am optimistic this could become a novel way of treating cancer. There are already drugs on the market, and others are being studied, that target the ribosomal intergenic noncoding RNA as well as the heat shock chaperone pathway."
 
For more information on long non-coding RNAs, watch the video below from Genetics Professor Ahmad Khalil.
 
 

Sources: Eurekalert!/AAAS, via University of Miami, Developmental Cell
 
About the Author
  • Experienced research scientist and technical expert with authorships on over 30 peer-reviewed publications, traveler to over 70 countries, published photographer and internationally-exhibited painter, volunteer trained in disaster-response, CPR and DV counseling.
You May Also Like
OCT 18, 2021
Genetics & Genomics
A Decade After Gene Therapy, SCID Patients Are Doing Well
OCT 18, 2021
A Decade After Gene Therapy, SCID Patients Are Doing Well
For decades, scientists have been trying to find ways to cure disorders that can be traced back to an error in one gene. ...
OCT 20, 2021
Microbiology
Bacteria From Cats Could Help Treat Infections
OCT 20, 2021
Bacteria From Cats Could Help Treat Infections
Many animals, including humans and cats, harbor huge colonies of microbes, which may live in places like the skin, or th ...
NOV 11, 2021
Health & Medicine
The Taconic-Cyagen Academic Model Generation Alliance
NOV 11, 2021
The Taconic-Cyagen Academic Model Generation Alliance
With more than 15 years of experience in genetic engineering, Cyagen utilizes a highly efficient process, including prop ...
NOV 22, 2021
Health & Medicine
Important Considerations in the Humanization of Antibodies
NOV 22, 2021
Important Considerations in the Humanization of Antibodies
In therapeutic applications, monoclonal antibodies (mAbs) provide highly precise targeting of pathological cells and red ...
NOV 29, 2021
Cell & Molecular Biology
Researchers Discover a New Type of Cell in the Retina
NOV 29, 2021
Researchers Discover a New Type of Cell in the Retina
Many types of cells in the eye were identified 100 years ago. But researchers found something new there.
DEC 03, 2021
Cell & Molecular Biology
Researchers Create Living Robots That Can Self-Replicate
DEC 03, 2021
Researchers Create Living Robots That Can Self-Replicate
In this image by Douglas Blackiston and Sam Kriegman, a red parent is seen with its green 'offspring'
Loading Comments...