MAR 11, 2018 4:59 PM PDT

Sheep may Help Grow Human Organs for Transplant

WRITTEN BY: Carmen Leitch

Researchers have long thought that if we could grow organs for transplantation, thousands of people who are desperate to get those new organs would no longer languish on waiting lists, and would instead get the help they need immediately. But there are many hurdles to be overcome before we can easily generate human organs that are perfectly functional, and won’t get rejected. New work by scientists at Stanford and UC Davis has taken steps to meet some of those challenges. The researchers were able to successfully grow human stem cells inside of sheep embryos for 28 days, as a proof-of-concept. 

Sheep could act as a kind of incubator for human organs one day. / Image credit: Pexels

An organism that carries cells that have different genetic material is called a chimera. In this case, the chimeric organism, a sheep, would carry genomes from different species; the idea is to implant them with stem cells that could develop into human organs, and then harvest those organs when mature. 

This strategy could also help to relieve the problem of organ rejection. When the work was announced by Stanford Geneticist Hiro Nakauchi, the research leader, he emphasized that point. Using stem cells from a patient to grow a new organ would generate a perfect match that posed no threat to the patient’s immune system.

"Although they are formed inside the body of animals, the cells are derived from a patient's own stem cells," Nakauchi said at the annual meeting of the American Association for the Advancement of Science.

There is still much more work to be done before such organs are ready for use in the clinic. The National Institute of Health also does not yet fund this kind of research. However, this research is an important step toward helping the thousands of people that are waiting for a new organ; the scientists have also taken steps to ensure that they are addressing any ethical concerns about the use of chimeras.

Nakauchi told Stanford: “More than 116,000 patients are on the waiting list and 20 people die each day in the United States alone due to a lack of donor organs. Animal-grown organs could transform the lives of thousands of people facing organ failure. I don’t understand why there continues to be resistance. We could help so many people.”

Sources: Stanford, Business Insider

About the Author
  • Experienced research scientist and technical expert with authorships on 28 peer-reviewed publications, traveler to over 60 countries, published photographer and internationally-exhibited painter, volunteer trained in disaster-response, CPR and DV counseling.
You May Also Like
APR 06, 2020
Cell & Molecular Biology
APR 06, 2020
A Regulator of Fatty Acid Uptake is Identified
Scientists have found a protein that helps control how much fat is absorbed by cells in the body.
APR 09, 2020
Cell & Molecular Biology
APR 09, 2020
A Model of Spinal Development Provides Insight Into Disease
The spinal column develops from a row of structures called somites, which bud off sequentially in a process called somit ...
APR 26, 2020
Cell & Molecular Biology
APR 26, 2020
Researchers Remotely Trigger the Release of Hormones
It may one day be possible to treat hormone-related diseases using this method.
MAY 18, 2020
Cell & Molecular Biology
MAY 18, 2020
Just One Fatty Meal Can Impair Focus
Many tasty and convenient foods are high in fat, and new research has suggested that just one fatty meal may hinder our ...
JUN 09, 2020
Cell & Molecular Biology
JUN 09, 2020
Custom Manufacturing: Translating Research into Product
Scientists around the world are focusing their energy and resources on translating advances made in clinical research in ...
JUL 02, 2020
Cell & Molecular Biology
JUL 02, 2020
The Intricate Movements of a Critical Receptor are Revealed
Scientists have now learned more about a critical protein in the brain called the NMDA receptor, tracking every atom as ...
Loading Comments...