JUN 29, 2017 7:00 AM PDT

Dual-labeled PSMA Ligand Delivers a Diagnosis-Therapy Combo Punch to Prostate Cancer

WRITTEN BY: Daniel Duan

During its annual member meeting in June the Society of Nuclear Medicine and Molecular Imaging, an international body that promotes the science, technology and excellence in practice of nuclear medicine and molecular imaging, awarded the 2017 image of the year to a team of German researchers. The work provided by the group is a pictorial summary of data and images that showcase the three-stage application of a dual-labeled imaging probe designed for prostate cancer diagnosis.

Dual-labeled PSMA-inhibitors for PET/CT imaging and fluorescence-guided intraoperative identification of prostate cancer and metastases. Credit: Society of Nuclear Medicine and Molecular Imaging

Prostate is a small walnut-shaped gland that produces the sperm-transporting seminal fluid. About one out of seven men will be diagnosed with prostate cancer during his lifetime. When detected early, 90% prostate cancer is curable. Because treatment is highly individualized, molecular imaging technologies are dramatically improving staging and treatment planning: it helps to pinpoint the location of a tumor, and the extent of the disease. Information collected from scanning provides detail on the molecular properties of the disease and the phenotypes of the patients, which allow physicians to choose the most effective treatment plan among prostate-removal surgery, radiation therapy and chemotherapy.

What is special about the German researchers’ work is that their PSMA (prostate specific membrane antigen)-seeking probe is labeled with positron emitting isotope gallium-68 and an infrared dye for multimodality imaging purpose. This combo package combines the advantages of PSMA-based PET (positron emitting tomography) imaging, and intraoperative gamma and fluorescence imaging. The clear identification of tumor (its location, size and border with healthy tissue) helped surgeons plan and execute clean tumor resection. It represents a state-of-art technology in disease diagnosis and treatment strategizing that leads to improved clinical confidence and outcome.

Thumbnail image: a male patient diagnosed with prostate cancer. PSMA-specific PET imaging probe was shown localized on the cancer. Credit: Society of Nuclear Medicine and Molecular Imaging

Source: Society of Nuclear Medicine and Molecular Imaging

About the Author
  • Graduated with a bachelor degree in Pharmaceutical Science and a master degree in neuropharmacology, Daniel is a radiopharmaceutical and radiobiology expert based in Ottawa, Canada. With years of experience in biomedical R&D, Daniel is very into writing. He is constantly fascinated by what's happening in the world of science. He hopes to capture the public's interest and promote scientific literacy with his trending news articles. The recurring topics in his Chemistry & Physics trending news section include alternative energy, material science, theoretical physics, medical imaging, and green chemistry.
You May Also Like
AUG 05, 2021
Space & Astronomy
Einstein Was Right, Again: X-rays Observed Behind a Black Hole for the First Time
AUG 05, 2021
Einstein Was Right, Again: X-rays Observed Behind a Black Hole for the First Time
  In an astrophysics first, a team of researchers have directly observed light coming from the backside o ...
SEP 09, 2021
Chemistry & Physics
"Shape-Shifting" Birds: Climate Change's Newest Outcome
SEP 09, 2021
"Shape-Shifting" Birds: Climate Change's Newest Outcome
A new study released last Tuesday highlights a surprising response to climate change: physical changes in animal mo ...
SEP 14, 2021
Space & Astronomy
NASA is Planning to Shoot a Spacecraft Into an Asteroid
SEP 14, 2021
NASA is Planning to Shoot a Spacecraft Into an Asteroid
NASA can detect asteroids, so there's been plenty of speculation about what might happen if we discover an asteroid ...
SEP 22, 2021
Chemistry & Physics
Commercial Fusion Energy Could be Within Reach, Thanks to the World's Most Powerful Magnet
SEP 22, 2021
Commercial Fusion Energy Could be Within Reach, Thanks to the World's Most Powerful Magnet
Commonwealth Fusion Systems (CFS) announced this month that their new magnet might be the breakthrough needed to make fu ...
OCT 28, 2021
Health & Medicine
Smart Bandage Measures Moisture Level of Healing Wounds
OCT 28, 2021
Smart Bandage Measures Moisture Level of Healing Wounds
A common problem in wound care is determining what’s below the surface of the bandage. Once a dressing is applied, ...
OCT 31, 2021
Space & Astronomy
Researchers Create & Sustain Otherworldly 'Superionic' Ice
OCT 31, 2021
Researchers Create & Sustain Otherworldly 'Superionic' Ice
Water can assume an astonishing array of conformations. It can be a liquid, vapor, or different kinds of solids. Scienti ...
Loading Comments...