JUL 19, 2019 11:11 AM PDT

Possible Non-Hormonal Treatment For Endometriosis On Horizon

WRITTEN BY: Abbie Arce

With over 200,000 cases reported annually, endometriosis is a big concern in women’s health. Scientists don’t yet know what causes the painful disorder. It is characterized by the abnormal growth of the endometrium outside the uterus. The endometrium bleeds and is shed each month during menstruation. Endometrial tissues outside the uterus behave in the same way. This tissue and blood then have no place to exit the body. 

The tissue surrounding the misplaced endometrium can become irritated, which can eventually lead to scarring. Scarring and adhesions can, over time, cause pelvic tissue and organs to stick together. If the condition has spread to involve the ovaries, an ovarian cyst may form. In addition to severe pain, this condition is the most common cause of infertility in women.

The diagnosis of endometriosis generally includes a series of questions from the doctor. Doctors may ask about the location of your pain and when it occurs. Tests typically include a pelvic exam in which the doctor manually feels for cysts. An ultrasound, MRI, or laparoscopy may also be used to view inside the body for a more detailed analysis. While imaging tests are more common, the more-invasive laparoscopy is most often used in surgical planning to give detailed information to a surgeon about the extent of the condition.

Treatment for endometriosis generally focuses on hormonal methods. These can cause adverse side effects like fertility suppression and therefore are not ideal. Additionally, surgery to remove endometrial implants or even the entire uterus with ovaries are considered, but again not ideal.

New research has found that macrophages play a central role in the development of endometrial growths. Though they intend to protect the body, macrophages are altered by exposure to the disease environment. These immune cells, once altered, help to develop the blood supply for endometrial growth. They also help stimulate the growth of nerve cells in the area through the release of IGF-1. 

The research suggests that blocking the release of IGF-1 from disease-modified macrophages may help prevent the body from supporting these abnormal growths, and provide a non-hormonal form of relief for the condition.

 

Sources: World Endometriosis Research Foundation, TEDFASEB

About the Author
  • Abbie is an AFAA certified personal trainer and fitness instructor with an interest in all things health-science. She has recently graduated with her BS in Applied Sport and Exercise Science from Barry University in Miami. Next, she intends to earn an MPH with a focus in Epidemiology.
You May Also Like
SEP 15, 2019
Immunology
SEP 15, 2019
New Observations of a Cancer Transcriptase
New research shows a transcriptase that helps time cell death varies in expression, and is unusually localized, in cancer cells.  The transcriptase, T
SEP 22, 2019
Technology
SEP 22, 2019
Blood Incubation Using Laser Technology
The world’s first ever blood incubator was developed using laser technology and could someday prevent fatal blood transfusions in critically ill pati
DEC 22, 2019
Clinical & Molecular DX
DEC 22, 2019
Can Google Health's AI interpret X-rays as well as radiologists?
Patients presenting with severe coughs, chest pain or suspected infections are more than likely to be sent for a chest X-ray -- the most commonly taken med
JAN 11, 2020
Neuroscience
JAN 11, 2020
Molecular Therapy to Self-Repair Nerve Cells
Neurodegenerative diseases such as Multiple Sclerosis (MS), Alzheimer's, and Huntington's Disease are predicated on damage to myelin on nerve cells
MAR 05, 2020
Drug Discovery & Development
MAR 05, 2020
Human Stem Cells Cure Type 1 Diabetes in Mice
In the US alone, around 187,000 children and adolescents have Type 1 diabetes, alongside 1.4 million people aged 20 and over. Managing their condition with
MAR 16, 2020
Clinical & Molecular DX
MAR 16, 2020
New diagnostic tech uses AI to screen blood for over 1400 pathogens
New and reemerging microbial threats continue to challenge the public health and infectious disease response teams world...
Loading Comments...