APR 14, 2020 8:00 AM PDT

Urchin-shaped DNA Biosensor Detects Disease Earlier

WRITTEN BY: Tara Fernandez

 

For researchers at the Missouri University of Science and Technology developing a new class of nanodiagnostics, good things come in small packages. With their novel DNA biosensor technology, they have created an inexpensive, ultrasensitive diagnostic tool that is capable of catching cancer and genetic diseases faster and more accurately.

Professor of chemistry, Risheng Wang led a team that published a study featured in the journal Analytical Chemistry, demonstrating the precision and time-saving potential of this discovery.

“Biosensing with nanomaterials has the advantages of greater sensitivity and faster response than traditional analytical methods that require today's medical devices and time-consuming molecular amplification techniques,” said Wang.

What are DNA biosensors? In general, they consist of three major elements: a recognition element that binds specifically to a biological target, a signal converter that transmits information and a processor. The sensor can pick up characteristic patterns on the levels of various biological molecules in a patient’s sample: from nucleic acids to protein antibodies.

 

 

The biosensor designed by Wang and team had a distinctive spheroidal molecular structure that resembled the shape of a sea urchin, consisting of carbon nanotubes and gold nanoparticles. The specific structural conformation and the chosen materials resulted in the biosensor’s robust electrochemical output.

Wenyan Liu, co-author on the research article provided insights on why this innovative platform outperforms currently-available diagnostic systems, saying, “Because the combination of carbon nanotubes and gold nanoparticles produced a larger-than-normal, super-conductive contact area, we found this biosensor could detect the ultralow-abundance nucleic acids in complex biological media.”

This fusion of biomedical engineering, nanotechnology, point-of-care diagnostics and biology could be a critical inflection point for how we diagnose and treat chronic diseases in future.



Sources: Analytical Chemistry, Phys Org.

 

About the Author
  • Tara Fernandez has a PhD in Cell Biology and has spent over a decade uncovering the molecular basis of diseases ranging from skin cancer to obesity and diabetes. She currently works on developing and marketing disruptive new technologies in the biotechnology industry. Her areas of interest include innovation in molecular diagnostics, cell therapies, and immunology. She actively participates in various science communication and public engagement initiatives to promote STEM in the community.
You May Also Like
OCT 06, 2020
Clinical & Molecular DX
Radioactive Tracer Shines the Floodlights on Inflammation
OCT 06, 2020
Radioactive Tracer Shines the Floodlights on Inflammation
A patient checks into the hospital with difficulty breathing. Is inflammation to blame? How can physicians visualize are ...
OCT 17, 2020
Clinical & Molecular DX
Imaging Innovation Set to Ease the Pain of Osteoarthritis
OCT 17, 2020
Imaging Innovation Set to Ease the Pain of Osteoarthritis
In osteoarthritis, the joint cartilage that cushions bones begins to break down, causing debilitating pain and stiffness ...
OCT 20, 2020
Clinical & Molecular DX
Non-coding RNA As A Barometer For Liver Health
OCT 20, 2020
Non-coding RNA As A Barometer For Liver Health
October is liver cancer awareness month — a month dedicated to educating people about the risk factors and prevent ...
OCT 24, 2020
Clinical & Molecular DX
Software Flags Elevated Cerebral Palsy Risk in Premies
OCT 24, 2020
Software Flags Elevated Cerebral Palsy Risk in Premies
Diagnostic imaging scientists have developed a software tool for predicting the future onset of cerebral palsy in babies ...
DEC 03, 2020
Clinical & Molecular DX
Spit Contains Concussion Clues
DEC 03, 2020
Spit Contains Concussion Clues
Drowsiness, confusion, headaches, and sensitivity to light — it’s sometimes hard for doctors to spot the sig ...
DEC 30, 2020
Neuroscience
Brain Imaging Predicts Risk of PTSD
DEC 30, 2020
Brain Imaging Predicts Risk of PTSD
Until now, why posttraumatic stress disorder (PTSD) develops in some and not others following a physical and/ or psychol ...
Loading Comments...