APR 21, 2020 1:00 PM PDT

New Diagnostic FET-based Biosensor Enables Rapid Detection of SARS-CoV-2

WRITTEN BY: Lawrence Renna

The coronavirus disease 2019 (COVID-19) pandemic continues to be at the forefront of the world’s attention. COVID-19 is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, there is still a considerable need to develop diagnostic tests for the SARS-CoV-2 that are rapid, easy to implement, and more accurate than existing tests. New research, published on April 20, 2020, in the journal ACS Nano details the discovery of a new diagnostic test that uses a field-effect transistor (FET)-based biosensor to detect SARS-CoV-2. This new technology can detect very small concentrations of the virus (concentrations of 1 fg/mL) from samples collected from nasopharyngeal (deep nasal passage) swabs.

A majority of the currently available diagnostic tests for SARS-CoV-2 involve a technique called real-time reverse transcription-polymerase chain reaction (RT-PCR). In RT-PCR, a tiny amount of the virus’ ribonucleic acids (RNA), collected from the patient, are copied millions to billions of times in order to amplify the signal and detect the virus. Unfortunately, this ‘copying’ process typically takes at least 3 hours and requires an additional, time-consuming step to prepare the virus’ RNA for amplification. Thus, rapid detection is not currently possible.

Enter FET-based diagnostic biosensors! FETs are common electrical components used in many different integrated circuits for a variety of applications. Edmond Changkyun Park, Seung Il Kim, and colleagues developed a FET-based biosensor based on a sheet of graphene, with antibodies attached to it, that can instantly and easily detect SARS-CoV-2. Their technique does not require any additional steps to prepare the sample from the patient for testing. The FET-based diagnostic tool works by modulating the electrical signal from the device when the virus binds to the attached antibodies. Their device was highly sensitive to SARS-CoV-2 and did not show any false-positives from other similar viruses such as the Middle East respiratory syndrome-related coronavirus (MERS-CoV). This new diagnostic device would enable instant detection of SARS-CoV-2 in patients. Also, this FET-biosensor can be adapted for the easy and rapid detection of other viruses that already exist or may emerge in the future.

 

 

Sources: American Chemical Society, ACS Nano

About the Author
  • Hello! I am a scientist currently living in Southern California, although I am originally from the east coast. I received my B.S. in Chemistry from Northeastern University in 2012, and my Ph.D. in Chemistry from the University of Massachusetts Amherst. I also had a postdoctoral appointment at the University of California, Irvine. I have written 25+ peer-reviewed articles, several patents, and one book chapter. I am a reviewer for scientific manuscripts, and a freelance editor and writer. Outside of science, I enjoy spending time with my family, training Jiu-Jitsu, and baking sourdough bread. I am happy to be writing for LabRoots.
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