APR 22, 2020 11:39 AM PDT

Microneedle Skin Patch Collects Bodily Fluids for On-patch Diagnostic Testing

WRITTEN BY: Lawrence Renna

The collection of blood for diagnostic tests is common practice in clinical settings. However, technicians often need to separate plasma from serum, which adds additional time and complexity to the process. Also, many patients are terrified of needles being stuck in their veins. Therefore, when it comes to diagnostic testing, a simple new method that avoids using needles and drawing blood would benefit the field of clinical diagnostics. New research out of the George Institute of Technology and Washington University published in ACS Sensors details the development of a microneedle patch that painlessly attaches to the patient’s skin and collects interstitial fluid (ISF) for on-patch point-of-care diagnostic testing.

ISF is a bodily fluid that fills the interstitial space between cells. ISF contains many of the same biomarkers that are also present in the blood. However, ISF can be simpler to use in diagnostic testing than blood because it does not contain any cells or clotting agents. Patches that contain microneedles can collect ISF from the skin. Remarkably, the needles are so small that patients do not feel any pain when it is attached to their skin. Until now, the ISF collected from microneedles needs to undergo complicated multistep processes, such as biomarker extraction, centrifugation, sample loading, and analysis for diagnostic testing.

The microneedle patch developed by Srikanth Singamaneni, Mark Prausnitz, and colleagues collects ISF from the skin and delivers it to plasmonic paper containing gold nanorods. Diagnostic testing can be performed directly on the patch’s plasmonic paper in a single step. This improvement dramatically reduces the time and complexity of ISF diagnostic testing. The mechanism of detection is called surface-enhanced Raman scattering (SERS), a phenomenon in which absorbed molecules modulate the scattering of light by metal nanostructures. SERS has the capability to enhance the signal of the molecule of interest greater than 10 billion times, which makes single-molecule detection a possibility in the future. As a proof-of-principle, the researchers were able to detect dye that was injected into rats in their ISF using SERS.

 

 

Sources: American Chemical Society, ACS Sensors, and The Journal of the American Chemical Society

About the Author
  • Hello! I am a scientist currently living in Southern California, although I am originally from the east coast. I received my B.S. in Chemistry from Northeastern University in 2012, and my Ph.D. in Chemistry from the University of Massachusetts Amherst. I also had a postdoctoral appointment at the University of California, Irvine. I have written 25+ peer-reviewed articles, several patents, and one book chapter. I am a reviewer for scientific manuscripts, and a freelance editor and writer. Outside of science, I enjoy spending time with my family, training Jiu-Jitsu, and baking sourdough bread. I am happy to be writing for LabRoots.
You May Also Like
NOV 07, 2020
Neuroscience
Device Measures Stress Hormones with Earwax
NOV 07, 2020
Device Measures Stress Hormones with Earwax
Researchers from University College London and King’s College London in the UK have developed a device that can me ...
NOV 13, 2020
Chemistry & Physics
Mid-IR Spectroscopy a Convenient, Accurate Means of Cancer Diagnosis
NOV 13, 2020
Mid-IR Spectroscopy a Convenient, Accurate Means of Cancer Diagnosis
Last Sunday, November 8, was the International Day of Radiology (IDoR 2020), an event celebrated by radiologists, techno ...
DEC 02, 2020
Clinical & Molecular DX
Digital Platform Watches for a Silent COVID Killer
DEC 02, 2020
Digital Platform Watches for a Silent COVID Killer
 
DEC 03, 2020
Neuroscience
Scientists Invent Noninvasive Microscope to Observe Neurons
DEC 03, 2020
Scientists Invent Noninvasive Microscope to Observe Neurons
To obtain high-resolution images of the brain, researchers usually need to reduce the thickness of the skull or cut into ...
DEC 24, 2020
Clinical & Molecular DX
Feeling Unmotivated? It Could Be Dementia.
DEC 24, 2020
Feeling Unmotivated? It Could Be Dementia.
Apathy, characterized by a pronounced lack of enthusiasm, motivation, or interest, is a predictor of the future onset of ...
DEC 29, 2020
Clinical & Molecular DX
Injectable Heart Health Tracker Now Picks Up COVID Red Flags
DEC 29, 2020
Injectable Heart Health Tracker Now Picks Up COVID Red Flags
The statistics are a real eye-opener: in the United States, one person dies every 36 seconds from cardiovascular disease ...
Loading Comments...