AUG 06, 2020 8:18 AM PDT

Gut Feeling: Spotting the Early Signs of Gastric Cancer

WRITTEN BY: Tara Fernandez

In a study published in Science Advances, scientists propose a new method for diagnosing gastric cancer, the third leading cause of death worldwide.

A gastric cancer diagnosis is usually linked to a poor clinical outcome. The reason? It’s notoriously difficult to diagnose this type of cancer in the early stages and by the time it is detected, the cancer may have already spread extensively. A diagnostic peritoneal lavage (a surgical diagnostic procedure to sample fluids in the abdominal cavity) is usually done in the case of suspected gastric cancer. The problem is that these fluid samples have very few if any, metastatic cancer cells during the early stages. Because of this, standard detection methods fall short.

The study led by Yuzhao Zhang from the Shenyang Institute of Automation in China describes a biomedical engineering breakthrough: a microfluidic chip that rapidly separates and characterizes floating gastric cancer cells. “Microfluidics technologies are used to precisely control, manipulate, and analyze fluids through deliberately designed microchannels,” the authors explain in the publication.

Gastric cancer develops when cells lining the stomach become malignant. Age, diet, smoking, and some infections can increase the risk of gastric cancer, with early symptoms including nausea, heartburn, and bloating.

Gastric cancer cells differ from normal peritoneal lavage cells in terms of their sizes and electrical characteristics. The microfluidic chip solved the problem of the low sensitivity in standard tests, by separating cancer cells from the normal abdominal fluid with a purity of up to 71 percent. Besides being sensitive, the new device was also rapid, separating cells in around 5 minutes.

This is the first time that scientists have been able to capture living gastric cancer cells from peritoneal lavages. “In the future, separated live cancer cells could be further cultured and used to study the mechanism of peritoneal metastasis,” the authors write.

 

Source: Science Advances


 

About the Author
  • Tara Fernandez has a PhD in Cell Biology and has spent over a decade uncovering the molecular basis of diseases ranging from skin cancer to obesity and diabetes. She currently works on developing and marketing disruptive new technologies in the biotechnology industry. Her areas of interest include innovation in molecular diagnostics, cell therapies, and immunology. She actively participates in various science communication and public engagement initiatives to promote STEM in the community.
You May Also Like
JAN 01, 2021
Genetics & Genomics
Common Brain Disorder Has a Genetic Influence
JAN 01, 2021
Common Brain Disorder Has a Genetic Influence
It's thought that as many as one in one hundred people are born with a brain disorder known as Chiari 1 malformation, bu ...
JAN 31, 2021
Genetics & Genomics
Targeting Aneuploidy in Cancer Cells
JAN 31, 2021
Targeting Aneuploidy in Cancer Cells
Cancer is typically related to problems in cells' genomes that lead to uncontrolled cell growth, and the formation of tu ...
MAR 02, 2021
Clinical & Molecular DX
Test Before You Travel: Tiny Smartphone Device Checks for COVID in 60 Minutes
MAR 02, 2021
Test Before You Travel: Tiny Smartphone Device Checks for COVID in 60 Minutes
According to the CDC’s latest travel regulations, all air passengers must have a negative COVID test before boardi ...
MAR 18, 2021
Cardiology
Searching for New Cardiovascular Biomarkers
MAR 18, 2021
Searching for New Cardiovascular Biomarkers
Do you want to know what the best medicine for cardiovascular health is? It isn't some heart-shaped pill with some m ...
MAR 31, 2021
Clinical & Molecular DX
A Non-Invasive Look at Fat Distribution in the Liver
MAR 31, 2021
A Non-Invasive Look at Fat Distribution in the Liver
The build-up of fat inside the liver is a worrying sign that points to the possibility of conditions such as nonalcoholi ...
APR 27, 2021
Cardiology
New miRNAs Might Help Diagnose Severe Dilated Cardiomyopathy
APR 27, 2021
New miRNAs Might Help Diagnose Severe Dilated Cardiomyopathy
The heart is one of the most reliable parts of the body. It pumps day and night, delivering fresh oxygen and nutrients t ...
Loading Comments...