MAY 04, 2016 5:10 AM PDT

'Lab-on-a-Chip' Device Detects Glucose from Sweat

WRITTEN BY: Xuan Pham
Diabetes is a worldwide epidemic; nearly 422 million people worldwide are afflicted with this chronic condition. Timely and accurate blood glucose monitoring is essential in the diagnosis, treatment, and management of diabetes. To that end, researchers in China have developed an ultrasensitive “lab-on-a-chip” device that can measure glucose concentrations with one drop of sweat.
Lab-on-a-chip device measures glucose via sweat
Diabetes mellitus is characterized by the body’s inability to regulate blood glucose levels. The disease involves insulin, a hormone produced naturally in the body that stimulates the uptake of glucose in the body’s cells. In diabetes there is a deficiency of insulin, either because beta cells in the pancreas are unable to produce insulin (Type 1 diabetes), or because the normal insulin is produced in insufficiently quantities (Type 2 diabetes). Both forms of diabetes require constant and vigilant monitoring of blood glucose, as too much or too little can lead to severe health conditions.
 

The new glucose sensor is based on fiber optic technology and microfluidics, two innovations that make the device ultrasensitive, cheap, and portable.
 
“Today, photonic approaches are recognized as the most promising techniques for ultrasensitive sensing,” said A. Ping Zhang, associate professor at the the Hong Kong Polytechnic University. “In particular, the synergistic integration of photonic sensing and microfluidics led to the state-of-the-art technology known as ‘optofluidics’ for biological and chemical analysis.” Optofluidics technology combines the detection of chemicals with the use of light, and microfluidics, where small amounts of fluids pass through microchannels on a chip.
 
Use of fiber optics allows the device to operate without electromagnetic interference, a problem which plagued previous generations of electrochemical glucose sensors. And the fiber optics also increase the sensitivity of glucose detection. According to the team, the device can sense extremely low glucose concentrations, even as low as 1 nM. In addition to sensitivity, the device purportedly reduces the response time, from 6 minutes to 70 seconds, according to the team.
 
Among the innovations for the portable glucose sensors, perhaps the one patients can relate to the most is the promise for a pain-free sugar check. This is because the device can function in solution, which means glucose measures can be obtained from just a single drop of sweat. For some diabetics that perspire easily, the device could replace painful finger pricks; however, for those who perspire less, finger pricks may still be necessary.
 
The team’s ultimate aim is to develop a range of lab-on-a-chip devices that are multifunctional in many areas of diagnostics. But for now they hope the device can provide a means for earlier diagnosis and more effective monitoring of diabetes.

Additional source: MNT, Optical Society Press Release
About the Author
  • I am a human geneticist, passionate about telling stories to make science more engaging and approachable. Find more of my writing at the Hopkins BioMedical Odyssey blog and at TheGeneTwist.com.
You May Also Like
JUL 13, 2019
Clinical & Molecular DX
JUL 13, 2019
Problems In Diagnostics
While the history of medicine is incredibly interesting, it is, in equal parts, entirely horrifying. In the past, everything from bloodletting, to the bori...
AUG 08, 2019
Cardiology
AUG 08, 2019
The Best Way to Test Blood Pressure and Find Heart Disease
Heart disease causes hundreds of thousands of deaths annually -- can a new study on blood pressure tests guide doctors toward earlier diagnosis? About one ...
SEP 26, 2019
Cannabis Sciences
SEP 26, 2019
Arthritis Foundation Gives Cautious Thumbs Up for CBD Use
After a national survey in July confirmed that the vast majority of arthritis patients were either interested in using CBD for symptom relief or already us...
JAN 07, 2020
Clinical & Molecular DX
JAN 07, 2020
Saliva Test for Early Detection of Mouth and Throat Cancer
“OPC is one of the fastest rising cancers in Western countries due to increasing HPV-related incidence, especially in younger patients. It is paramou...
JAN 28, 2020
Clinical & Molecular DX
JAN 28, 2020
Protein complex discovered as first biomarker of PTSD
  Researchers at the Centre for Addiction and Mental Health (CAMH) and the Canadian Institutes of Health Research (CIHR) have identified a potential d...
FEB 19, 2020
Clinical & Molecular DX
FEB 19, 2020
Forget complicated scans - ovarian cancer can be detected in the blood
Results from clinical trials performed in Melbourne, Australia have revealed the diagnostic potential of a new test for ovarian cancer. Instead of using co...
Loading Comments...