JUN 06, 2018 12:49 AM PDT

Metformin Safe for Diabetics with CKD

WRITTEN BY: Nouran Amin

An oral diabetes drug, by the name of metformin, is suggested to be safe for most diabetic individuals with chronic kidney disease (CKD) according to a recent research study.

For the treatment of type 2 diabetes, Metformin is prescribed as the first-line medication. However, the use of Metformin has raised concerns in the medical community because it is believed that it may lead to lactic acidosis, explains a senior study author Morgan Grams, M.D.,Ph.D., M.H.S., an associate professor of medicine and epidemiology at the Johns Hopkins University School of Medicine.

A rare but serious complication, lactic acidosis is caused by lactate accumulation in the bloodstream that leads to severe muscle pain, cramps, and weakness. This means that diabetic individuals with CKD hold an increased risk of metformin-associated lactic acidosis. An effective examination of lactic acidosis risk could "provide reassurance that millions of people with diabetes and CKD may be able to safely use metformin," explains Grams. Older studies show that metformin holds great benefits beyond the purview blood sugar control. These benefits include less weight gain, lower risk of a heart attack, and higher long-term survival than other blood-sugar controlling prescriptions. "Our study demonstrates that the first-line and common diabetes medication is safer in patients with CKD than once thought," Grams says. "From a public health perspective, the potential benefits of using metformin for patients with diabetes and CKD are vast, given the increasing number of people affected with both diseases worldwide."

For the research study, Grams and co-authors examined 2004-2017 medical record data taken from 75,413 patients with type 2 diabetes managed by Geisinger Health System in Pennsylvania. Investigators analyzed data from the patients' estimated glomerular filtration rates (eGFRs -- a measure of kidney function), prescription drugs used for diabetes management, acidosis hospitalization visits, demographics, smoking habits/status and any indication of cardiovascular disease. The researchers used computer-based statistical models to study the risk of acidosis development in metformin users in comparison to metformin nonusers. Some conditions were adjusted for cardiovascular disease and smoking status. Overall, the research team found a relationship between metformin use and acidosis which was evident in patients with severely decreased kidney function. The researchers found a strikingly high risk in patients with severely decreased kidney function who were on a different type of diabetic medication. Additionally, the investigators compared new metformin users with new users of other diabetic managing drugs known as sulfonylureas within different categories of CKD stages.

"Our results support cautious use of metformin in patients with type 2 diabetes and eGFR of at least 30 mL/min/1.73 m2," Grams says. While investigators believe that this data is promising, they warn that patients receiving metformin may have varying underlying risk of lactic acidosis than patients who have not received metformin.

Source: Johns Hopkins Medicine

About the Author
  • Nouran earned her BS and MS in Biology at IUPUI and currently shares her love of science by teaching. She enjoys writing on various topics as well including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
APR 11, 2020
Cancer
APR 11, 2020
The Mice Make the Difference in CAR-T Studies
It is quite common in cancer therapies to see a drug or treatment that has been around for decades. New drugs are hard t ...
APR 21, 2020
Cannabis Sciences
APR 21, 2020
Is CBD Effective Against Women's Health Issues?
Products containing cannabidiol (CBD) are increasingly known as a natural and effective way to handle a wide range of wo ...
MAY 07, 2020
Immunology
MAY 07, 2020
New COVID-19 Vaccine Defends Monkeys Against Infection
Researchers from Beijing-based Sinovac Biotech have reported preliminary results of a study into the development of a va ...
MAY 06, 2020
Cancer
MAY 06, 2020
Olanzapine useful for cancer patients managing nausea unrelated to chemo
A study published last week in JAMA Oncology reports that a generic drug called Olanzapine could be useful for cancer pa ...
MAY 23, 2020
Cancer
MAY 23, 2020
A New Biomarker to Identify a Triple Negative Breast Cancer Prognosis
Breast cancer, one of the most common cancers in the world, are commonly separated into one of several sub-types. These ...
MAY 10, 2020
Drug Discovery & Development
MAY 10, 2020
Antiviral Drug Treats Naso-Pharyngeal Cancer
Scientists at Hong Kong Baptist University (HKBU) developed a novel anti-Epstein-Barr virus (EBV) drug that can shrink t ...
Loading Comments...