SEP 24, 2018 07:56 PM PDT

Pain Management Drug Found Ineffective in Traumatic Injury Patients

WRITTEN BY: Nouran Amin

Image via Scientific American

Driven by the effort to identify effective non-opioid pain medications, a recent international research study with a publication in the Journal Neurology, found that the drug ‘pregabalin’ is not effective in treating chronic pain associated with traumatic nerve injury. "The unrelenting burning or stabbing symptoms due to nerve trauma are a leading reason why people seek treatment for chronic pain after a fall, car accident, or surgery," explains John Markman, M.D., director of the Translational Pain Research Program in the University of Rochester Department of Neurosurgery and lead author of the study. "While these finding show that pregabalin is not effective in controlling the long-term pain for traumatic injury, it may provide relief for patients experience post-surgical pain."

Watch Video Below To Learn More About Traumatic Brain Injury:

Marketed under Pfizer, Pregabalin is under the name Lyrica and is approved to treat chronic pain associated with shingles, spinal cord injury, fibromyalgia, and diabetic peripheral neuropathy. But, is commonly a prescription drug for treating chronic nerve injury syndromes that occur after motor vehicle accidents, falls, sports injuries, knee or hip replacement and as well as surgeries that include hernia repair or mastectomy. Previously, an eight-week study showed that pregabalin decreased pain intensity better than placebo in chronic, post-traumatic pain syndromes. The findings resulted in many doctors to prescribe pregabalin for long-term pain that takes a while to resolve.

The present study, consisting of a retrospective analysis, found that pregabalin did not hold high efficacy for pain management in individuals with traumatic nerve injury. "The possibility that there was pain relief for those patients who had a hernia repair, or breast surgery for cancer, or a joint replacement lays the groundwork for future studies in these post-surgical syndromes where there is so much need for non-opioid treatments," says Markman. "Given the rising rates of surgery and shrinking reliance on opioids, it is critical that we understand how to study new drugs that work differently in patients like the ones included in this study.”

Source: University of Rochester Medical Center

About the Author
  • Nouran enjoys writing on various topics including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
DEC 15, 2019
Drug Discovery & Development
DEC 15, 2019
Evolutionary-Busting Cancer Drug
Researchers at the Institute of Cancer Research in London have discovered that a new type of drug that blocks treatment in cancers. The drug works by inhib...
DEC 15, 2019
Drug Discovery & Development
DEC 15, 2019
Nanomesh Development Advances Drug Delivery's Fight Against Antibiotic-Resistance
As concern over medication-resistant bacteria grows, researchers at Flinders University have now fabricated nanomeshes as an effective drug delivery method...
DEC 15, 2019
Drug Discovery & Development
DEC 15, 2019
Therapeutic Targets Inflammation Associated with Genetic Heart Disease
Often times when young athletes collapse during the game it is due to sudden cardiac death as a result of the inherited arrhythmogenic cardiomyopathy (ACM)...
DEC 15, 2019
Cancer
DEC 15, 2019
C2 combination targets cancer cells more efficiently
Treating cancer is in part so difficult because to be effective, high doses of aggressive drugs must be administered to patients. These treatments often ha...
DEC 15, 2019
Drug Discovery & Development
DEC 15, 2019
Parkinson's Drug Reduces Hallucinations in Dementia Patients
Pimavanserin, also known as Nuplazid, was approved in the US to treat Parkinson’s-related psychosis in 2016. Now, new research has shown that it also...
DEC 15, 2019
Drug Discovery & Development
DEC 15, 2019
Drug To Treat Ulcerative Colitis
Biomedical researchers at the University of California—Riverside, found that the therapeutic drug ‘tofacitinib’ used in treating autoimmu...
Loading Comments...