OCT 31, 2018 9:02 AM PDT

Cytostatic Drug Proved Potent For Cancer

WRITTEN BY: Nouran Amin

Image via ArcoMed

A study published in journal Angewandte Chemie, describes how a cytostatic drug, consisting of therapeutically active molecules that is linked to specific antibodies can treat tumors. Such novel conjugates are made from antibodies and a protein that inhibits kinesin spindle formation.

The study revealed that changing the “linkage” between these two components allows for the drugs cytostatic activity in a broad palette of cancers.

The purpose of the study was to introduce a new cytostatic drug that will not produce adverse effects on cancer patients. This is especially true since many medications may be effective but interfere with physiological regulatory mechanisms that cause the impairment of immune defenses, produce hair loss, and induce nausea.

Watch the short video below on side-effects of chemotherapeutic drugs:

The study was aimed at introducing a cytostatic drug directly into tumor cells before triggering a toxic effect. One proposed way was to attach small drug molecules to an antibody (that binds to specific sites—antigens) and produce a conjugate.

The linker will serve as a bridging component that will hold the conjugate together for as long as it circulates in the blood. Although incorporating cytostatic drugs into antibody conjugates have been so far successful, they are limited.

Diverging away from the classic mechanisms of cytostatic drugs, researchers have opted to use cytotoxin that which that utilizes a different biological pathway. More specifically, the cytotoxin is a novel pyrrole-based kinesin spindle protein (KSP) inhibitor which is implicated centrosome separation during cell division. Low doses of this cytoxin is highly effective enough to inhibiting this step of the cell cycle leading to a strong antitumor effect. The researchers have demonstrated that use of this technique can produce a highly effective antibody conjugates that allow them to target a variety of tumor types.

Image Credit: Wiley Online Libraries

The developed conjugates were seen to be very potent in vitro and when using experiments on mice, the conjugates led to complete remission of a human bladder tumor model with minimal side effects

Source: Wiley

About the Author
  • Nouran is a scientist, educator, and life-long learner with a passion for making science more communicable. When not busy in the lab isolating blood macrophages, she enjoys writing on various STEM topics.
You May Also Like
MAY 06, 2021
Drug Discovery & Development
Tweaked Version of Ketamine Could Solve the Opioid Crisis
MAY 06, 2021
Tweaked Version of Ketamine Could Solve the Opioid Crisis
Medications that manage post-operative pain are some of the main entry points to opioid addiction and overdose in the US ...
MAY 17, 2021
Cell & Molecular Biology
Survey Results: Where Is Pluripotent Stem Cell Research Now?
MAY 17, 2021
Survey Results: Where Is Pluripotent Stem Cell Research Now?
Human pluripotent stem cell (hPSC) lines are now commonly used across the globe. In the lab, researchers rely on hPSCs t ...
MAY 13, 2021
Health & Medicine
New Peptide Allows Cannabis to Fight Pain With Fewer Side Effects
MAY 13, 2021
New Peptide Allows Cannabis to Fight Pain With Fewer Side Effects
THC-rich cannabis is well known to bring relief for some chronic pain sufferers. But the downside, off putting for many ...
MAY 31, 2021
Immunology
Engineering Faster, More Agile T Cell Cancer Fighters
MAY 31, 2021
Engineering Faster, More Agile T Cell Cancer Fighters
Cell therapies use engineered T cells extracted from the patient’s own immune system to rally an attack on tumors. ...
JUL 15, 2021
Drug Discovery & Development
The genomics of high blood pressure - a road to the future of treatment
JUL 15, 2021
The genomics of high blood pressure - a road to the future of treatment
The human heart begins to beat in utero in the early weeks of development and continues throughout life. In an average l ...
AUG 02, 2021
Microbiology
The Unique Microbiomes of Long-Lived People
AUG 02, 2021
The Unique Microbiomes of Long-Lived People
What's the secret of people that live a long life? The answer may be complex but for some, it could include the microbio ...
Loading Comments...