JAN 01, 2019 05:23 PM PST

Restoring The Fountain of Youth

WRITTEN BY: Nouran Amin

According to a study published in Nature Communications, a drug treatment that aided the immune system in eradicating old cells in aging mice assisted in the restoration of youthful characteristics. The research study, performed at the Weizmann Institute of Science and led by Professor Valery Krizhanovsky and Dr. Yossi Ovadya in the Molecular Cell Biology Department, sheds new light onto aging science.

Watch this video below to learn more about the science of aging:

The study began onto an investigation on how the immune system is involved in clearing senescent cells (old cells) that result in complications if left hanging around the body too long. For one, senescent cells are cells that are not actually dead but too old to produce basic biological functions--the presence of these senescent cells can promote inflammation and thus have been implicated in diseases of aging. Therefore, the study looked into model mice that have a missing gene needed for this immune system activity. In other words, these mice were aging because of a great accumulation of senescent cells in comparison to mice in which the gene for removing these cells was present. The mice with the missing gene suffered chronic inflammation along with the vanishing of important biological functions ultimately resulting in premature death.

Image Credit: Berkeley Science Review

The researchers then gave the aging mice a drug that blocks the function of certain proteins needed to help aging cells thrive in their senescent state. The purpose of adding the drug was to examine if it’s possible that it would contribute to the eradication of senescent cells. Results showed that treated mice had an improvement in immune system activity and their tissues were close to appearance to much younger mice. A decrease in the degree of inflammation along with a fewer number of senescent cells were found to be present after drug treatment.

Drug treatment eliminates senescent cells from tissues of old mice. The blue staining shows senescent cells in lung and liver tissue. The amount of the staining is significantly reduced following the drug treatment.

Credit: Weizmann Institute of Science

Overall, treated mice were found to be more active along with an increase in their median lifespan. Researchers are now looking forward to examining new approaches that influence how the human body removes its aging cells in hopes of creating future "anti-aging" therapies.

Source: Weizmann Institute of Science

About the Author
  • Nouran enjoys writing on various topics including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
SEP 21, 2019
Chemistry & Physics
SEP 21, 2019
Take TAT, Cancer! Canadian Institutes Join Forces to Develop Targeted Alpha Therapy Agents
Targeted radionuclide therapy (TRT) applies radiolabeled biological vectors that can target a specific biomarker and deliver a lethal dose of radiation to...
SEP 21, 2019
Drug Discovery & Development
SEP 21, 2019
Experimental Drug Encourages Bone Growth in Children with Dwarfism
An experimental drug called vosoritide, alters certain proteins that block bone growth, which allowed the average annual growth of bone in a study of 35 ch...
SEP 21, 2019
Drug Discovery & Development
SEP 21, 2019
Anticholinergic Drugs and Dementia?
A link between anticholinergic drug use and cognitive impairment was recently observed from observational studies on randomized clinical trials. Regenstrie...
SEP 21, 2019
Health & Medicine
SEP 21, 2019
High Risk: Seizures and Coma Linked to Use of Synthetic Cannabinoids in Adolescents
A recent study by the American Academy of Pediatrics states that exposure to acute synthetic cannabinoid toxicity is far more dangerous to the adolesc...
SEP 21, 2019
Drug Discovery & Development
SEP 21, 2019
Comparison of Three Frontline Breast Cancer Drugs
Breast cancer affects 250,000 women in the U.S. annually. Those with most common form test positive for hormone receptors (HR+) and negative for the HER2 r...
SEP 21, 2019
Genetics & Genomics
SEP 21, 2019
New Gene Editing Technology to Combat Hereditary Diseases
Until recently, many types of gene-editing methods were unable to target critical parts of DNA. Now however, researchers at the Salk Institute have develop...
Loading Comments...