AUG 20, 2019 2:37 PM PDT

Lab-on-a-chip Advances Search for Anti-Clotting Drugs

WRITTEN BY: Nouran Amin

A novel ‘lab-on-a-chip’ the size of a postage stamp could soon advance the developments of safer anti-clotting drugs for heart attack and stroke prevention. The effective use of current anti-clotting drugs are limited due to risk in complications which prompted the need for alternative therapeutics that can be safe to avoid the risk of a fatal bleed and strong enough for preventing blood clotting formation.

RMIT.EDU: The chip features a unique system of tiny channels and pumps for rapidly manipulating fluids.

Now, the new biocompatible lab-on-a-chip, which is detailed procedurally in the journal Analytical Chemistry, will help accelerate the search for new anti-clotting drugs. The development was designed to work with the complexity and sensitivity of the biology of blood.

"Blood is extremely sensitive to artificial surfaces and clots very easily, so blood-handling technologies must be equally sensitive," says lead investigator Dr. Warwick Nesbitt, who worked with various collaborators to pioneer the device. "We've combined a deep understanding of the biology of blood with precision microfabrication engineering and design, to deliver a device that can work with whole blood and produce reliable results.

The device can effectively function as a medical pathology laboratory onto a small chip, and uses quick automated processes that can be achieved in a few minutes which would instead take days in a full-sized lab. It features a system of micropumps and unique analysis tools to study the effectiveness of chemical compounds on blood clots.

Learn more about the early history of lab on a chip:

"We hope this powerful new tool will give researchers an edge in delivering better and safer anti-clotting treatments, to improve the health and wellbeing of millions around the world."

"It's a key step towards the development of quick and efficient microsystems for pre-clinical and clinical hematology screening and diagnostics,” says Dr. Crispin Szydzik on how the micro lab can mimic conditions inside blood vessels.

Source: Science Daily

About the Author
  • Nouran is a scientist, educator, and life-long learner with a passion for making science more communicable. When not busy in the lab isolating blood macrophages, she enjoys writing on various STEM topics.
You May Also Like
JAN 19, 2021
Immunology
Food Allergies Be Gone: Nanoparticles Call for an Immune Ceasefire
JAN 19, 2021
Food Allergies Be Gone: Nanoparticles Call for an Immune Ceasefire
Milk, eggs, peanuts, tree nuts, wheat, soy, fish, and shellfish—these foods are among the most unwanted list for t ...
FEB 07, 2021
Drug Discovery & Development
Beta-Blockers Can Repair Broken Blood Vessels
FEB 07, 2021
Beta-Blockers Can Repair Broken Blood Vessels
Propranolol is a drug that can treat infantile haemangiomas but was found to also treat a blood vessel condition that le ...
MAR 04, 2021
Infographics
All You Need to Know about COVID-19 Vaccines
MAR 04, 2021
All You Need to Know about COVID-19 Vaccines
After over a year lockdowns brought on by the pandemic, hopes for returning to something even similar to ' ...
APR 14, 2021
Drug Discovery & Development
Anti-Aging Compound Improves Glucose Uptake
APR 14, 2021
Anti-Aging Compound Improves Glucose Uptake
According to new research at Washington University School of Medicine in St. Louis, a substance shown to counteract aspe ...
MAY 06, 2021
Drug Discovery & Development
Tweaked Version of Ketamine Could Solve the Opioid Crisis
MAY 06, 2021
Tweaked Version of Ketamine Could Solve the Opioid Crisis
Medications that manage post-operative pain are some of the main entry points to opioid addiction and overdose in the US ...
MAY 06, 2021
Cannabis Sciences
New CBD Analog Outperforms Regular CBD for Pain Relief
MAY 06, 2021
New CBD Analog Outperforms Regular CBD for Pain Relief
Researchers from Temple University Health System have found that a novel cannabidiol (CBD) analog can reverse pain sensi ...
Loading Comments...