DEC 09, 2019 9:15 AM PST

Could the diabetic drug 'metformin' extend a healthy lifespan?

WRITTEN BY: Nouran Amin

The most commonly prescribed diabetic medication for the Type 2 condition is ‘Metformin’—a drug with a mysterious mechanism of action but ultimately controls blood sugar levels. Now, a collaborative team of researchers have aimed to investigate metformin using computational analysis. Their findings, published in Cell Reports, shows that metformin involves key biochemical actviation in many cellular physiology that support an extension of a healthy lifespan.

“These results provide us with new avenues to explore in order to understand how metformin works as a diabetes drug, along with its health-span-extending effects,” says Professor Reuben Shaw, co-corresponding author of the paper and the director of Salk’s NCI-designated Cancer Center. “These are pathways that neither we, nor anyone else, would have imagined.”

Computational analysis revealing targets of metformin. Caption and Image Credit: Salk Institute

Earlier studies on metformin revealed that the only biochemical mechanism activated by its action was the ‘AMPK pathway’ which stalls cell growth and alters metabolism when nutrients are low. However, these studies led scientists to believe that more pathways are activated by metformin beyond the AMPK.

Learn more:

“Being mentored by John Yates, one of the top mass spectrometry investigators in the world, and Reuben Shaw, an expert in the field of metabolism, enabled me to both develop and apply a novel technology to a critical biological question: What pathways are regulated by metformin in the liver?” says Ben Stein, first author and postdoctoral associate at Weill Cornell Medical College.

How scientists were able to tell what kind of pathways were specifically activated? For one, they developed a novel method to investigate proteins known as ‘kinases’ that transfer phosphate groups and are critical on/off switches in cells that can be rapidly flipped by the actions of metformin. These regulatory kinases are involved in aging which thus implicates metformin.

“The results broaden our understanding of how metformin induces a mild stress that triggers sensors to restore metabolic balance, explaining some of the benefits previously reported such as extended healthy aging in model organisms taking metformin. The big questions now are what targets of metformin can benefit the health of all individuals, not just type 2 diabetics,” says William R. Brody Chair.

Source: Science Daily

About the Author
  • Nouran earned her BS and MS in Biology at IUPUI and currently shares her love of science by teaching. She enjoys writing on various topics as well including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
JAN 27, 2020
Health & Medicine
JAN 27, 2020
FDA Cautions Against Cannabis Use During Pregnancy
A recent article published by NPR addresses the rapidly growing number of females using cannabis during pregnancy. Those with tough pregnancy side effects ...
JAN 27, 2020
Drug Discovery & Development
JAN 27, 2020
Gene Variant Could Be a Therapeutic Target For Alzheimer Disease
A variation in genetics for an individual at high-risk for Alzheimer development has defied the odds for being dementia-free way beyond anticipated. The in...
JAN 27, 2020
Neuroscience
JAN 27, 2020
Suicidal Mitochondria Responsible for ALS
Scientists at Northwestern University have dicovered a new mechanism in the brain that may be responsable for the early stages of neurodegeneration seen in...
JAN 27, 2020
Drug Discovery & Development
JAN 27, 2020
Effective Therapeutic Approved for Migraines
The U.S Food and Drug Administration has now approved a new medication for migraines. The drug is called ‘ubrogepant (Ubrelvy)’ and comes in th...
JAN 27, 2020
Health & Medicine
JAN 27, 2020
Babies in Africa Receive World's First Malaria Vaccine
Would you accept a vaccine that was only 40% effective? For those at risk of malaria, the answer is likely a resounding, "yes!" According to the...
JAN 27, 2020
Drug Discovery & Development
JAN 27, 2020
Treating Malaria: Molecular Understanding of Drug Interactions
Crystallization is a process central to drug development that despite centuries of facilitating a particular method, chemists are still learning how to gra...
Loading Comments...