DEC 16, 2019 1:17 PM PST

Drug Targets Against The Nipah Virus

WRITTEN BY: Nouran Amin

The Nipah virus, first identified in 1998 and is transmitted from pigs and bats, has resulted in a high mortality rate killing more than half of all infected individuals in Bangladesh and India. Although, there has not been more than 150 fatalities from the virus, it is still a deadly threat that may lead to a pandemic. To counteract that issue, researchers have examined the molecular structure of the virus to come up with 150 possible drug targets.

Learn more about the Nipah virus:

The drug targets identified were possible inhibitors of the virus that block its detrimental effects. In the study, researchers from the Indian Institute of Science Education first modeled in 3D nine Nipah virus proteins before designing inhibitory molecules that block the activity of the protein. They then tested the efficacy of these inhibitors on 15 different viral strains.

Using computational analysis, they identified 4 putative peptides inhibitor therapeutics against the Nipah virus protein products and an additional 146 small molecule inhibitors. Overall, thirteen compounds were believed to the most promising based on characteristics such as strength, stability, and effectiveness against variable Nipah viral strains.

"We conclude that it is highly likely that the proposed inhibitors would be potent against all strains of the virus Nipah and other related zoonotic viruses that pose a serious epidemic threat," the researchers say. "Computational approaches can help identify and design inhibitors that could be rapidly tested or even deployed."

Findings were published in the journal, PLOS Neglected Tropical Diseases.

Source: Science Daily

About the Author
BS/MS
Nouran is a scientist, educator, and life-long learner with a passion for making science more communicable. When not busy in the lab isolating blood macrophages, she enjoys writing on various STEM topics.
You May Also Like
APR 28, 2022
Health & Medicine
Antidepressants Not Associated Improved Quality of Life
APR 28, 2022
Antidepressants Not Associated Improved Quality of Life
According to a recently published study in PLoS, antidepressants do not improve health-related quality of life (HRQoL) o ...
JUN 06, 2022
Drug Discovery & Development
Express Media Service Q&A with Sheng Li, PhD., FUJIFILM Irvine Scientific
JUN 06, 2022
Express Media Service Q&A with Sheng Li, PhD., FUJIFILM Irvine Scientific
FUJIFILM Irvine Scientific sat down with Sheng Li, PhD, Program Manager, to speak about our rapid service for small-scal ...
MAY 19, 2022
Drug Discovery & Development
Repurposed Antibiotic Shows Promise Against COVID-19 in Mice
MAY 19, 2022
Repurposed Antibiotic Shows Promise Against COVID-19 in Mice
An antibiotic known as clofoctol has shown promise in treating SARS-CoV-2 in mice. The corresponding study was published ...
MAY 22, 2022
Drug Discovery & Development
Gout Medication Helps Hospitalized People with Heart Failure
MAY 22, 2022
Gout Medication Helps Hospitalized People with Heart Failure
A research team at the University of Virginia Hospital System found that a regularly-used medication for gout, called co ...
JUN 10, 2022
Drug Discovery & Development
The consequences of inappropriate antibiotic prescriptions in children
JUN 10, 2022
The consequences of inappropriate antibiotic prescriptions in children
The discovery of antibiotics in the early 1900’s was one of the most important discoveries in medical history. The ...
JUN 29, 2022
Microbiology
Unleashing the Genetic Power of Ocean Microbes
JUN 29, 2022
Unleashing the Genetic Power of Ocean Microbes
By analyzing over 1,000 samples of the marine environment, researchers have reconstructed the genomes of 25,000 novel mi ...
Loading Comments...