FEB 12, 2020 6:52 PM PST

Diabetic Drug Increasces Risk of Heart Complications

WRITTEN BY: Nouran Amin

A drug by the name of ‘rosiglitazone’ used to treat type 2 diabetes was found to be associated with increased risk of heart problems, especially heart failure. Findings were based on a comprehensive evaluation of the cardiovascular risk from rosiglitazone use.

Rosiglitazone belongs to a class of drugs known as thiazolidinediones that help target blood sugar levels in patients with type 2 diabetes, however, it can also increase the risk of heart complications. As a result, Rosiglitazone use was suspended in Europe and holds previous restrictions in the United States.

Researchers stated: "Our study highlights the need for independent evidence assessment to promote transparency and ensure confidence in approved therapeutics, and postmarket surveillance that tracks known and unknown risks and benefits."

Learn more:

But, since 2007, studies reported conflicting findings about whether rosiglitazone does lead to risky heart complications. These studies did not access raw data from patients and mostly were based on summary level data that was not to the highest reliability. The drug maker of rosiglitazone--GlaxoSmithKline (GSK)--has placed effort to make patient data available for investigators and thus prompted researchers to re-analyze uncertainty about the role of the drug in cardiovascular risk.

"Our study suggests that when evaluating drug safety and performing meta-analyses focused on safety, IPD might be necessary to accurately classify all adverse events," noted the researchers. "By including these data in research, patients, clinicians, and researchers would be able to make more informed decisions about the safety of interventions."

Source: Science Daily

About the Author
  • Nouran earned her BS and MS in Biology at IUPUI and currently shares her love of science by teaching. She enjoys writing on various topics as well including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
SEP 27, 2020
Cell & Molecular Biology
How Spiders May Open a Path to IBS Treatment
SEP 27, 2020
How Spiders May Open a Path to IBS Treatment
Irritable bowel syndrome (IBS) is term that describes a gut disorder that causes abdominal pain, cramping, diarrhea or c ...
OCT 27, 2020
Cardiology
Boron Could Prevent Myocardial Fibrosis and Assist in Recovery
OCT 27, 2020
Boron Could Prevent Myocardial Fibrosis and Assist in Recovery
When you pass by the nutrition section at the local grocery store, there is a chance you’ll come across row upon r ...
OCT 01, 2020
Drug Discovery & Development
Antidepressants Treats Lazy Eye
OCT 01, 2020
Antidepressants Treats Lazy Eye
A study published in Current Biology revealed how a therapeutic used as an antidepressant and for managing pain could tr ...
OCT 10, 2020
Drug Discovery & Development
Fishnet of Nanoparticles Traps Drug Molecules
OCT 10, 2020
Fishnet of Nanoparticles Traps Drug Molecules
‘Fishnet’ Nanoparticles Traps Drug Molecules A team at Northwestern University have casted a net of nanopart ...
NOV 06, 2020
Immunology
The Coronavirus Is No Match Against Sybody 23
NOV 06, 2020
The Coronavirus Is No Match Against Sybody 23
The virus that causes COVID-19, SARS-CoV-2, uses its spike protein to gain access to cells, by binding to the ACE2 recep ...
NOV 22, 2020
Cannabis Sciences
Public Believes CBD is Cure-All Despite Lack of Evidence
NOV 22, 2020
Public Believes CBD is Cure-All Despite Lack of Evidence
Many people think that cannabidiol (CBD), a non-psychoactive compound in cannabis, can reduce symptoms from various cond ...
Loading Comments...