MAR 13, 2020 9:56 PM PDT

Ibuprofen's Effects on Liver

WRITTEN BY: Nouran Amin

Ibuprofen is a popular painkiller and over-the-counter (OTC) that belongs to a group of drugs referred to as nonsteroidal anti-inflammatory drugs, or NSAIDs. Now, a research study at the University of California, Davis shows that ibuprofen holds significant effects on the liver than previously thought. Findings were published in Scientific Reports.

Learn more about pain relievers:

Ibuprofen is used for pain and fever and has been known to cause heart problems and increase stroke risk—but, researchers were unware of the effects on the liver.

"We found that ibuprofen caused many more protein expression changes in the liver than we expected," said Professor Aldrin Gomes, Department of Neurobiology, Physiology and Behavior in the UC Davis College of Biological Sciences

Researchers use advanced mass spectrometry to identify metabolic pathways that were alter in mice who were treated with ibuprofen. These pathways are diverse and include the metabolism of amino acids, hormones and vitamins. Through the studies, gender differences in ibuprofen effects mice were apparent in mice.

For example, cytochrome P450—which breaks down lungs, was found to be elevated in female mice treated with ibuprofen as opposed to males.

"The elevation in cytochrome P450 could mean that other drugs taken with ibuprofen could stay in the body for a longer duration in males and this has never been shown before. No drug is perfect, as all drugs have side effects. However, many commonly used drugs such as ibuprofen are being overused and should not be used for certain conditions such as mild pain," Gomes said. “In the long term, it is important for the scientific community to start addressing differences between males and females with respect to drug metabolism and effects.”

Source: Science Daily

About the Author
BS/MS
Nouran is a scientist, educator, and life-long learner with a passion for making science more communicable. When not busy in the lab isolating blood macrophages, she enjoys writing on various STEM topics.
You May Also Like
JUN 06, 2022
Cannabis Sciences
Price and Convenience: Key Reasons Why People Continue to Buy Illegal Cannabis
JUN 06, 2022
Price and Convenience: Key Reasons Why People Continue to Buy Illegal Cannabis
A study published in the Journal of Studies on Alcohol and Drugs found that price and convenience are the two main reaso ...
JUN 27, 2022
Drug Discovery & Development
Potential Gene Targets Identified for Treating Deafness
JUN 27, 2022
Potential Gene Targets Identified for Treating Deafness
Researchers have identified three mutations of the MINAR2 gene that are linked to deafness. They say that the mutations ...
JUL 01, 2022
Cannabis Sciences
Firefly Genes Provide Insights into Cannabis Biology
JUL 01, 2022
Firefly Genes Provide Insights into Cannabis Biology
A team of University of Connecticut researchers are using firefly genes to understand molecular mechanisms involved in t ...
JUL 04, 2022
Cannabis Sciences
Study calls for Improved Cannabis Product Labeling Practices
JUL 04, 2022
Study calls for Improved Cannabis Product Labeling Practices
Large scale study of cannabis product labeling highlights a critical need for more informative and accurate product desc ...
JUL 20, 2022
Neuroscience
What Does the Sleeping Brain Do When It Hears Music?
JUL 20, 2022
What Does the Sleeping Brain Do When It Hears Music?
A study published in Nature Neuroscience highlights brain activity that happens when a sleeping person hears music. A te ...
AUG 15, 2022
Drug Discovery & Development
New Drug Candidate Treats Over 300 Drug Resistant Bacteria
AUG 15, 2022
New Drug Candidate Treats Over 300 Drug Resistant Bacteria
Researchers have identified a new molecule that shows promise in inhibiting over 300 drug-resistant bacteria, including ...
Loading Comments...