MAR 16, 2020 9:43 PM PDT

Understanding How an Obesity-Treating Drug Functions

WRITTEN BY: Nouran Amin

Liraglutide is a drug targeted to help treat obesity by suppressing appetite, thus making the patient lose weight. However, up until now research has not determined the exact mechanisms of how this works.

"The goal is to produce even more weight loss treatments," said senior author Matthew R. Hayes, PhD, an associate professor of Psychiatry at Penn. "And this work takes us closer to fully realizing a better treatment strategy for obesity."

Learn more about obesity:

Now, a preclinical study done by the Perelman School of Medicine at the University of Pennsylvania and published in Science Translational Medicine indicates that liraglutide crosses the brain's blood barrier and engaging with the region of the brainstem known as the nucleus tractus solitarius (NTS). It was found that NTS balances food intake and energy expenditure.

"This discovery opens up the door for future obesity drug treatments that could be used in conjunction with this FDA-approved therapy to treat obesity," says Hayes. "The more we understand how drugs act, the more we can understand what other brain systems can be manipulated in combination with them to help patients lose more weight."

Liraglutide interacts with glucagon-like peptide-1 receptors (GLP-1R) on GABA neurons (specific form of brain cells) that suppress hunger.

"We've narrowed in on the NTS to more fully understand how this site in the brain is critically important for body weight regulation," said first author Samantha M. Fortin, PhD, a postdoctoral research fellow in Hayes' lab. "Our finding that GABA neurons in the NTS are important for the anorectic effects of liraglutide may prove to be meaningful in the future. Other compounds or genetic manipulations that would target this distinct population of cells in the brain could be useful in treating obesity."

Source: Science Daily

About the Author
  • Nouran is a scientist, educator, and life-long learner with a passion for making science more communicable. When not busy in the lab isolating blood macrophages, she enjoys writing on various STEM topics.
You May Also Like
MAY 22, 2021
Drug Discovery & Development
Drug Combo Treats 86% of Patients with Gout
MAY 22, 2021
Drug Combo Treats 86% of Patients with Gout
Researchers at the University of Michigan have found that a combination of two drugs is twice as effective as current tr ...
JUN 04, 2021
Drug Discovery & Development
Scientists Identify 90 Drugs that Could be Repurposed to Fight COVID-19
JUN 04, 2021
Scientists Identify 90 Drugs that Could be Repurposed to Fight COVID-19
Researchers from The Scripps Research Institute in California have identified 90 drugs that could be repurposed for trea ...
JUN 07, 2021
Cell & Molecular Biology
Overcoming Challenges to Detect Apoptosis in 3D Cell Structures
JUN 07, 2021
Overcoming Challenges to Detect Apoptosis in 3D Cell Structures
Researchers are increasingly relying on cells grown in three-dimensional (3D) structures to help answer their research q ...
JUN 09, 2021
Drug Discovery & Development
New Drug Prevents Dementia After Head Injury
JUN 09, 2021
New Drug Prevents Dementia After Head Injury
Researchers led by the University of South Australia have identified a new drug that may be able to help prevent athlete ...
JUN 14, 2021
Cell & Molecular Biology
Can An Omega-3 Fatty Acid Destroy Tumors?
JUN 14, 2021
Can An Omega-3 Fatty Acid Destroy Tumors?
The body needs fatty acts for a variety of functions, and the health benefits of taking fatty acid supplements have long ...
JUL 27, 2021
Immunology
Rethinking Immune Responses Involved in Skin Hypersensitivity
JUL 27, 2021
Rethinking Immune Responses Involved in Skin Hypersensitivity
A study by immunologists at the University of Copenhagen has revealed a never-before-seen immune pathway invol ...
Loading Comments...