APR 20, 2020 12:13 AM PDT

First Successful Vaccine for Middle-East Respiratory Syndrome

WRITTEN BY: Nouran Amin

Researchers have successfully completed the first-in-human clinical trial for a vaccine against MERS (Middle East Respiratory Syndrome).  Findings show that the MVA-MERS-S vaccine triggered the development of antibodies and T cell immunity.

Learn more about MVA-MERS-S:

"The results of this vaccine trial are also important and promising with regard to the development of a vaccine against SARS-CoV-2, the new coronavirus," explains Prof. Marylyn Addo, Head of the Division of Infectious Diseases at the UKE and scientist at the DZIF. "The development of the MERS vaccine provides a basis upon which we at the DZIF can rapidly develop a vaccine against the new coronavirus."

The MERS coronavirus was first identified in 2012 and was listed on the World Health Organization (WHO)’s Blueprint list for pathogens that may serve as a threat to human and public health. The virus is communicable from dromedary camels to humans—and from human to human infection. The virus causes a respiratory illness with a mortality rate of up to 35 percent. There hasn’t been an effective vaccine to date against the MERS coronavirus.

"In 2014, together with DZIF partners, we started to develop a vaccine against the MERS coronavirus in preparation for larger outbreaks of the virus in the future," Addo explains.

The vaccine is based on an attenuated virus that was previously been used in eradicating smallpox except it has been altered to contain MERS coronavirus protein components. The same vaccine is now being used for developing protection against the present SARS-CoV-2.

"The tolerability and safety of the vaccine candidate as well as the resulting immune responses are very promising," explains Dr. Till Koch, one of the first authors of the trial. "After the second injection of MVA-MERS-S, antibody formation and T cell responses occurred in 87 percent of the trial subjects," summarizes first co-author Dr. Christine Dahlke.

Prof. Stephan Becker is pleased, "These results show that the new vaccine could potentially be used in future MERS outbreaks."

Scientists are hopeful to use their findings from the trial to give ground to the potential development of a SARS-CoV-2 vaccine. The vaccine will likely use the same viral vector (MVA) by replacing the MERS-CoV spike protein with the SARS-CoV-2 spike protein.

Source: Science Daily

About the Author
  • Nouran earned her BS and MS in Biology at IUPUI and currently shares her love of science by teaching. She enjoys writing on various topics as well including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
APR 14, 2020
APR 14, 2020
Personalized Treatments for Patients with Diabetes and Heart Disease
Often, people who have Type 2 diabetes are at an increased risk for cardiovascular disease. This is because they are usu ...
APR 21, 2020
APR 21, 2020
Considerations for Lab Managers in Choosing a Microplate Reader
In today's high-tech, digitized laboratory environments, nobody pays very much attention to the humble plastic micro ...
APR 21, 2020
APR 21, 2020
A Nasal Vaccine Against Tau Tangles
  One of the hallmarks of Alzheimer’s disease (AD) is the accumulation of “tau tangles”. Tau is a ...
MAY 08, 2020
Drug Discovery & Development
MAY 08, 2020
Cholesterol Drugs May Boost Healthy Gut Bacteria in Obese People
While statins have long been known for their efficacy in treating high cholesterol, until recently, there was no evidenc ...
MAY 18, 2020
MAY 18, 2020
How do Ohnologs affect Cancer?
Genetics can be complicated to say the least. Sometimes it can be as simple as a single mutation in one gene that causes ...
MAY 14, 2020
MAY 14, 2020
New hope for immunotherapy for pediatric brain cancer
Pediatric brain cancer is an especially tough pill to swallow. While one in four children does not survive medulloblasto ...
Loading Comments...