MAY 22, 2020 9:55 PM PDT

Evaluating a Popular Diabetic Drug

WRITTEN BY: Nouran Amin

A study by researchers at UT Southwestern study shows that a previous drug for Type 2 diabetes may be effective when paired with another drug that eliminates problematic side effects. The drug ‘Rosiglitazone’ sold under the brand name Avandia, works by increasing insulin sensitivity and glucose tolerance. However, the drug was out of favor because of risks for cardiac problems, osteoporosis and obesity along with fluid retention.

Learn more about the history of Rosiglitazone usage and risk of cardiovascular problems:

"The very low dose we used in this study showed no side effects -- no weight gain, no fluid retention -- in mouse models," says Dayoung Oh, Ph.D., senior author of the study, assistant professor of internal medicine, and a researcher in UT Southwestern's Touchstone Center for Diabetes Research.

Findings from studies on mice were published in Cell Metabolism and shows how combining Rosiglitazone with an experimental drug referred to as Compound A will activate some cells that complement the actions of the first drug. They found that a combination of Compound A with a small dose of rosiglitazone produced a similar degree of insulin sensitivity as rosiglitazone at maximum dose alone.

“Additional research is needed to check for bone loss and heart problems at the lower dose,” says Oh, “but those effects too could likely be eliminated or lessened by reducing the dosage of rosiglitazone.”

Usage of rosiglitazone has remained low as result of the risk complications but it is FDA approved and researchers are hopeful for more clinical studies.

"For a long time, rosiglitazone has been used for treating Type 2 diabetes and insulin resistance," Oh says. Although there are other drugs to treat Type 2 diabetes, "this drug is very good -- very effective. But at the same time, there are still serious side effects, including weight gain, fluid retention, and more."

About 34 million Americans suffer from diabetes and 90 percent of these individuals are Type 2—the disease can lead to kidney disease, stroke, and cardiac complications. With the current study, there is renewed hope of Rosiglitazone use.

Learn more about Type 2 diabetes:

 

 

"The hope is that we will be able to use rosiglitazone at lower doses to treat Type 2 diabetes patients in a more effective way without side effects," Oh says.

The study was supported by grants from the National Institutes of Health, the American Heart Association, and the American Diabetes Association.

Source: Science Daily

About the Author
BS/MS
Nouran is a scientist, educator, and life-long learner with a passion for making science more communicable. When not busy in the lab isolating blood macrophages, she enjoys writing on various STEM topics.
You May Also Like
APR 20, 2022
Immunology
Rare Soil Microbe Shows Promise as New Antibiotic
APR 20, 2022
Rare Soil Microbe Shows Promise as New Antibiotic
  Antibiotic resistance has increased the demand for new antibiotic treatments. Now, researchers have found that a ...
APR 21, 2022
Drug Discovery & Development
No Link Between Antidepressants and Improved Quality of Life
APR 21, 2022
No Link Between Antidepressants and Improved Quality of Life
Those who use antidepressant medications have a similar health-related quality of life to people who are depressed and w ...
MAY 05, 2022
Drug Discovery & Development
Insulin Nasal Spray Improves Cognitive Outcome for Diabetes Patients
MAY 05, 2022
Insulin Nasal Spray Improves Cognitive Outcome for Diabetes Patients
Diabetes is an increasingly common condition that affects at least 1 in 10 U.S adults. Millions more have prediabetes an ...
MAY 11, 2022
Cannabis Sciences
Legal Recreational Cannabis Reduces Prescription Drug Demand
MAY 11, 2022
Legal Recreational Cannabis Reduces Prescription Drug Demand
A research study published in Health Economics found a link between the availability of legal recreational cannabis, and ...
JUN 06, 2022
Microbiology
Light-Activated Nanoscale Drills Can Penetrate Bacteria
JUN 06, 2022
Light-Activated Nanoscale Drills Can Penetrate Bacteria
In 1999, a miniature rotor that could be moved reliably was attached to a molecule. Researchers have come a long way sin ...
JUN 07, 2022
Cell & Molecular Biology
Advances in Laboratory Automation Research at the 2022 Labroots Virtual Event
JUN 07, 2022
Advances in Laboratory Automation Research at the 2022 Labroots Virtual Event
Labroots hosted its 6th Annual Laboratory Automation Virtual Event on May 18, 2022. The speaker roster for this free con ...
Loading Comments...