JUN 18, 2020 10:37 AM PDT

Gilead to Trial COVID-19 Drug on Children

WRITTEN BY: Annie Lennon

Following the emergency use authorization given to Remdesivir on May 1, Gilead Sciences has announced that it will conduct a clinical trial of the drug on children. 

While older people are more likely to experience negative COVID-19 symptoms than children, an analysis of 1.3 million cases between January 22 and May 30 found that children aged nine and below have an incidence rate of 51 cases per 100,000 people. 

Although rare, children who contract the condition tend to develop multisystem inflammatory syndrome- a condition that inflames blood vessels throughout the body and may cause the failure of one or more organs. 

To help children at risk of this condition, Gilead plans to assess the drug's safety, tolerability, and efficacy in around 50 children suffering from moderate to severe COVID-19 symptoms. The company plans on including newborns and adolescents at over 30 sites between the US and Europe. Patient enrolment will begin soon, and the trial is expected to be finalized by the end of the year. 

The trial's success will be measured by the proportion of pediatric patients who will experience negative effects from the treatment and abnormalities as assessed by a lab. The researchers will also monitor plasma concentrations of Remdesivir and metabolites. 

"While the novel coronavirus appears to disproportionally affect adults, especially the elderly and those with underlying health conditions, concerning reports have been documented of children and young adults being hospitalised with Covid-19 and related autoimmune symptoms." says Merdad Parsey, the chief medical officer of Gilead Sciences.  

Remdesevir has been used to treat pediatric patients suffering from severe COVID-19 symptoms since February under the company's compassionate use program. 

Granted emergency use authorization by the FDA last month, the drug is currently the only drug that has approval for usage against COVID-19. This comes after the FDA withdrew its authorization for antimalarial drugs Chloroquine and Hyrdoxychloroquine following recent studies demonstrating their ineffectiveness in treating COVID-19.

 

Sources: Clinical Trials Arena, Market Watch

 

About the Author
  • Science writer with keen interests in technology and behavioral biology. Her current focus is on the interplay between these fields to create meaningful interactions, applications and environments.
You May Also Like
DEC 09, 2020
Drug Discovery & Development
Natural Sugar Alternative Stevia May Cause Gut Bacteria Imbalance
DEC 09, 2020
Natural Sugar Alternative Stevia May Cause Gut Bacteria Imbalance
Governments are keen to create regulations to reduce sugar intake. As such, companies are increasing their usage of arti ...
DEC 15, 2020
Cannabis Sciences
Could Cannabis Help in the Opioid Crisis?
DEC 15, 2020
Could Cannabis Help in the Opioid Crisis?
While cannabis is increasingly available for medicinal use, doctors largely remain unable to prescribe it to their patie ...
DEC 28, 2020
Immunology
Inhaling a Puff of Llama Antibodies to Relieve COVID
DEC 28, 2020
Inhaling a Puff of Llama Antibodies to Relieve COVID
Scientists at the National Institutes of Health have identified new antibody-based weapons in the fight against COVID-19 ...
JAN 24, 2021
Cannabis Sciences
Cannabis Compound CBD Shows Promise as Antibiotic
JAN 24, 2021
Cannabis Compound CBD Shows Promise as Antibiotic
Researchers from the University of Queensland, in collaboration with Botanix Pharmaceuticals Limited, have found that ca ...
JAN 26, 2021
Drug Discovery & Development
Gut Microbiota Reveals Drug Activity
JAN 26, 2021
Gut Microbiota Reveals Drug Activity
Inflammatory bowel diseases cannot be entirely cured but instead, the symptoms are treated with anti-inflammat ...
FEB 22, 2021
Drug Discovery & Development
Screening Macrocyclic Peptides
FEB 22, 2021
Screening Macrocyclic Peptides
Macrocyclic peptides are promising for pharmaceuticals for cancer—however, screening for them is challenging. Find ...
Loading Comments...