JUN 25, 2020 11:25 AM PDT

Three New Molecular Targets for Epilepsy

WRITTEN BY: Nouran Amin

A study lead by scientists at FutureNeuro discovered three new drugs hold the potential for targeting epilepsy. These drugs target a small set of microRNAs that control gene activity in the brain.

"Our approach to drug discovery has led us to new types of molecules that can be targeted to prevent seizures with hopefully fewer side effects." said Dr Cristina Reschke, FutureNeuro Research Fellow and Honorary Lecturer at RCSI, and Co-Lead Author. "Currently, most drugs used to treat epilepsy work by blocking the signals brain cells use to communicate. This results in many of the side effects experienced by people with epilepsy."

Epilepsy is a chronic brain disorder that affects the quality of life. Although treatments are present, research has lagged the past years making it a challenge for those living with treatment-resistant conditions,

Learn more about epilepsy:

"By characterising and targeting an entire new class of molecules in epilepsy, we hope to develop novel and innovative treatment strategies for temporal lobe epilepsy." said Dr Gareth Morris, Marie Sklodowska-Curie Actions Fellow at FutureNeuro and Co-Lead Author of the paper. "This is an important step closer to fulfilling the urgent and unmet clinical needs for the one third of people whose seizures are resistant to currently available drugs."

Findings were published in the Proceedings of the National Academy of Sciences (PNAS) USA.

Senior author on the study, Professor David Henshall, Director of FutureNeuro and Professor of Molecular Physiology and Neuroscience at RCSI said: "The project is a great example of team science, where groups with different areas of expertise combine to create innovative solutions that keep people with epilepsy as the central focus. The discoveries here may be just the tip of the iceberg for new strategies in the treatment of epilepsy. I'm optimistic this can be translated to the clinic."

Source: Science Daily

About the Author
  • Nouran earned her BS and MS in Biology at IUPUI and currently shares her love of science by teaching. She enjoys writing on various topics as well including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
MAY 19, 2020
Drug Discovery & Development
Can Chinese Drug Cure COVID-19 Without Vaccine?
MAY 19, 2020
Can Chinese Drug Cure COVID-19 Without Vaccine?
Researchers at China’s Peking University have announced that they are developing a treatment capable of blocking C ...
MAY 21, 2020
Cancer
A New Player in the Regulation of Cancer's Microenvironment
MAY 21, 2020
A New Player in the Regulation of Cancer's Microenvironment
Breast cancer is one of the most common cancers in the world.  Triple-negative breast cancer (TNBC) is a sub-type o ...
MAY 14, 2020
Drug Discovery & Development
Therapeutic for Gastrointestinal Tumors
MAY 14, 2020
Therapeutic for Gastrointestinal Tumors
The FDA has approved ripretinib (Qinlock) which is the first drug for fourth-line treatment of advanced gastrointestinal ...
MAY 25, 2020
Drug Discovery & Development
Potential Targets for Alcohol Induced Liver Disease
MAY 25, 2020
Potential Targets for Alcohol Induced Liver Disease
Alcohol-related liver disease (ALD) is a fatal condition targeting more than 150 million people. Part of what makes it d ...
JUN 14, 2020
Chemistry & Physics
Why Are There So Few Black People in STEM?
JUN 14, 2020
Why Are There So Few Black People in STEM?
On June 10th, 2020, thousands of STEM scientists and organizations around the world went on strike to protest systemic r ...
JUN 18, 2020
Drug Discovery & Development
Gilead to Trial COVID-19 Drug on Children
JUN 18, 2020
Gilead to Trial COVID-19 Drug on Children
Following the emergency use authorization given to Remdesivir on May 1, Gilead Sciences has announced that it will condu ...
Loading Comments...