AUG 18, 2020 2:27 PM PDT

Psychedelic Medicine Reduces Inflammation from Asthma

WRITTEN BY: Annie Lennon

Aside from mental health applications, psychedelics are also known for their antiinflammatory effects. And now, a company called Eleusis has received data from a preclinical study that may pave the way for psychedelic medicines to treat antiinflammatory conditions. 

The company's researchers investigated 21 psychedelic compounds known to target the serotonin receptor 5-HT2A. Previous research conducted on mice showed that activation of this receptor has an antiinflammatory effect on tissues of the blood vessels and gut. In particular, it was shown to reduce inflammation in asthma patients. 

Aware of their antiinflammatory potential, the researchers wanted to find a psychedelic that would not have the behavioral effects of most psychedelics. As such, they looked at how each of the drugs behaved in rats with allergic asthma. Although all drugs activated the 5-HT2A receptor, they differed in the ability to prevent airway constriction. Surprisingly, the researchers noted that LSD was ineffective. 

They did, however, find that one class of psychedelics called 2,5-dimethoxyphenethylamine (2C-H) was able to reduce inflammation without the behavioral effects of LSD or other psychedelics, despite its close relationship to mescaline and amphetamines.

"One main takeaway was that the potency of a given psychedelic wasn't predicted by its psychoactive properties," says Nichols said. "LSD, which is a super-potent psychedelic that produces behavioral effects at very low doses, is a relatively weak antiinflammatory. So the cellular effects that mediate antiinflammatory responses are very different from those that are underlying the behavioral effects."

The researchers will use their new insights to develop antiinflammatory drugs that can be delivered via the eye- a delivery method that further minimizes the risk of mental side effects. They say that their results will also inform the development of new chemical entities capable of treating other diseases, including rheumatoid arthritis. 

 

Sources: Fierce BiotechScience Direct

About the Author
  • Annie Lennon is a writer whose work also appears in Medical News Today, Psych Central, Psychology Today, and other outlets. When she's not writing, she is COO of Xeurix, an HR startup that assesses jobfit from gamified workplace simulations.
You May Also Like
JUL 07, 2021
Cancer
Chemotherapy Disrupts Gut Bacteria in Cancer Patients
JUL 07, 2021
Chemotherapy Disrupts Gut Bacteria in Cancer Patients
Researchers from Australia have found that the conventional chemotherapy used to treat various cancers disrupts the comp ...
JUL 29, 2021
Drug Discovery & Development
What is Ivermectin and Can it Treat COVID?
JUL 29, 2021
What is Ivermectin and Can it Treat COVID?
Lab tests in 2020 found that the widely available drug ivermectin had a weak effect on the SARS-CoV-2 virus and that unf ...
AUG 01, 2021
Neuroscience
Keto-based Dietary Supplement Reduces Epileptic Seizures
AUG 01, 2021
Keto-based Dietary Supplement Reduces Epileptic Seizures
K.Vita, a dietary supplement, reduced seizures by 50% in adults and children with drug-resistant epilepsy in its first c ...
AUG 10, 2021
Drug Discovery & Development
Epidemiology and postexposure prophylaxis of rabies virus
AUG 10, 2021
Epidemiology and postexposure prophylaxis of rabies virus
Rabies is a viral disease that can be transmitted from an infected animal to another animal or human. In the U ...
SEP 12, 2021
Coronavirus
Real-World, Post-Delta COVID-19 Vaccine Data & Potential Treatment
SEP 12, 2021
Real-World, Post-Delta COVID-19 Vaccine Data & Potential Treatment
New research may have identified a potential treatment or preventive medication for SARS-CoV-2 and other viral infection ...
SEP 13, 2021
Genetics & Genomics
Moderna is Developing mRNA Vaccines to Rescue Different Protein Defects
SEP 13, 2021
Moderna is Developing mRNA Vaccines to Rescue Different Protein Defects
A genome contains instructions for making genes, and when an organism needs to produce proteins, it transcribes a gene s ...
Loading Comments...