OCT 16, 2020 7:30 AM PDT

FDA Warns Against NSAIDs After Week 20 of Pregnancy

WRITTEN BY: Annie Lennon

The US Food and Drug Administration (FDA) has warned against using nonsteroidal anti-inflammatory drugs (NSAIDs) from 20 weeks into pregnancy. They say that usage of the drugs may cause a rare but serious kidney problem to the unborn child. While a well-known risk among certain medical specialties, the announcement comes as an effort to communicate more widely to other specialties and pregnant women. 

After around 20 weeks of gestation, unborn babies' kidneys produce most of the amniotic fluid they need- the protective cushion that helps their lungs, digestive system, and muscles develop. Kidney problems caused by the usage of NSAIDs can lead to lower levels of this fluid being produced, which can then lead to further health complications. 

The recommendations are the result of a review of medical literature, including case reports, randomized control studies, and observational studies. While most of the publications suggest that the condition, known as oligohydramnios, tends to occur in the third trimester, some reported an earlier onset from around 20 weeks of gestation. 

The review also stated that, in most cases, oligohydramnios was reversible within 72 hours to 6 days of discontinuing usage of the NSAID.

"It is important that women understand the benefits and risks of the medications they may take over the course of their pregnancy," says Patrizia Cavazzoni, MD, acting director of FDA's Center for Drug Evaluation and Research. "To this end, the agency is using its regulatory authority to inform women and their healthcare providers about the risks if NSAIDs are used after around 20 weeks of pregnancy and beyond."

The announcement comes after previous warnings against using NSAIDs, including ibuprofen and celecoxib, after week 30 of pregnancy due to heart-related risks. As such, manufacturers of NSAIDs will now be required to update their labeling. 

The FDA mentioned, however, that a low-dose (81mg) aspirin is excluded from the precaution. They also mentioned that if a healthcare provider believes that NSAIDs are necessary for women between week 20 and 30 of pregnancy, their usage should be limited to the lowest effective dose for the shortest duration possible. 

 

Sources: MedscapeFDA

About the Author
  • Science writer with keen interests in technology and behavioral biology. Her current focus is on the interplay between these fields to create meaningful interactions, applications and environments.
You May Also Like
OCT 23, 2020
Drug Discovery & Development
Common Asthmatic Treatments Increase Risk of Bone Fractures
OCT 23, 2020
Common Asthmatic Treatments Increase Risk of Bone Fractures
A study published in the journal Thorax found that taking steroid inhalers or tablets for asthma treatment to control fl ...
NOV 18, 2020
Cancer
Could Targeting the Proteasome be Effective Against Cancer?
NOV 18, 2020
Could Targeting the Proteasome be Effective Against Cancer?
One of the trickiest things about anti-cancer drug design is targeting. Today, most drugs on the market target critical ...
NOV 26, 2020
Drug Discovery & Development
Sestrin Increases the Lifespan of Fruit Flies
NOV 26, 2020
Sestrin Increases the Lifespan of Fruit Flies
Reduced food intake, known as dietary restriction, leads to a longer lifespan in many animals and can improve health in ...
DEC 15, 2020
Clinical & Molecular DX
Who Should Get the COVID Vaccine First?
DEC 15, 2020
Who Should Get the COVID Vaccine First?
Drug developers’ frantic hunt for vaccines against SARS-CoV-2 has finally begun to bear fruit, with several vaccin ...
DEC 20, 2020
Genetics & Genomics
A Repurposed Drug Can Treat a Genetic Disorder
DEC 20, 2020
A Repurposed Drug Can Treat a Genetic Disorder
Some researchers have sought to treat genetic diseases by correcting the mutation. But it may be possible to use another ...
DEC 21, 2020
Cancer
Examining the Bioactive Components of an Alga Against Cancer
DEC 21, 2020
Examining the Bioactive Components of an Alga Against Cancer
Many of today’s drugs come from vast libraries of synthetic compounds built by chemists for big pharma. This drug ...
Loading Comments...