OCT 10, 2020 4:34 PM PDT

Fishnet of Nanoparticles Traps Drug Molecules

WRITTEN BY: Nouran Amin

‘Fishnet’ Nanoparticles Traps Drug Molecules

A team at Northwestern University have casted a net of nanoparticples from polymers to advance drug delivery methods.

"We use a polymer that forms a wide net throughout an aqueous solution," said Northwestern's Evan A. Scott, who led the study. "Then we induce the net to collapse. It collects anything within the solution, trapping therapeutics inside of nanogel delivery vehicles with very high efficiency."

"It works like a fishing net, which first spreads out due to electrostatic repulsion and then shrinks upon hydration to trap 'fish,'" added Fanfan Du, a postdoctoral fellow in Scott's laboratory.

The polymer net collapses into nanoscale hydrogels (or nanogels) that captures over 95% proteins, DNA, or small molecule-based drugs.

Learn more about nanoparticles:

 

 

"Clinical application of self-assembled nanoparticles has been limited by difficulties with scalability and with loading large or multiple therapeutics, especially proteins," Scott said. "We present a highly scalable mechanism that can stably load nearly any therapeutic molecule with high efficiency."

Findings were reported in the journal Nature Communications.

"Adding more water induces the network to collapse, leading to the formation of nanogels," Du said. "The manner in which water is added affects the PPSU chain formation, which changes the nanogels' size and structure."

Source: Science Daily

About the Author
Master's (MA/MS/Other)
Nouran is a scientist, educator, and life-long learner with a passion for making science more communicable. When not busy in the lab isolating blood macrophages, she enjoys writing on various STEM topics.
You May Also Like
DEC 05, 2022
Drug Discovery & Development
Characterization and Manufacturing of AAVs for Gene Therapy
Characterization and Manufacturing of AAVs for Gene Therapy
The backdrop upon which every successful gene therapy is developed is the ability to safely and specifically target cell ...
NOV 29, 2022
Genetics & Genomics
Eliminating 'Toxic' RNA Molecules to Treat ALS & Dementia
Eliminating 'Toxic' RNA Molecules to Treat ALS & Dementia
Researchers have developed a way to target RNA molecules that can have a harmful result. Instead of targeting the genome ...
NOV 29, 2022
Drug Discovery & Development
Chemotherapy May Increase Disease Susceptibility for Two Generations
Chemotherapy May Increase Disease Susceptibility for Two Generations
A common chemotherapy drug may make future generations more susceptible to disease. The corresponding study was publishe ...
DEC 26, 2022
Immunology
An Antibody Successfully Treats Over 70% of Multiple Myeloma Patients in Trial
An Antibody Successfully Treats Over 70% of Multiple Myeloma Patients in Trial
Almost every patient who gets myeloma and is treated with a standard therapy also experiences relapse. But researchers h ...
JAN 05, 2023
Health & Medicine
Potential Over-the-Counter Access to Naloxone- a life saving drug
Potential Over-the-Counter Access to Naloxone- a life saving drug
Naloxone is a powerful FDA-approved opioid antagonist that works to reverse life-threatening opioid overdoses. Sinc ...
FEB 01, 2023
Health & Medicine
Webinar: Data Integrity and Connectivity for Lab Balances
Webinar: Data Integrity and Connectivity for Lab Balances
Data integrity is one of the most important criteria for reliable laboratory results and a hot topic for regulators and ...
Loading Comments...