NOV 16, 2020 3:23 AM PST

A Change of Heart

WRITTEN BY: Nouran Amin

For a long time cardiovascular issues related to the heart muscular wall have been addressed by therapeutics that targeted the symptoms of the disease rather than the structure and function of the cardiac muscle wall. Now, the first time, a medication has shown effects on targeting heart muscle thickness and function—particularly for the condition of HCM (hypertrophic cardiomyopathy).

"This is the first study to show a favorable impact of a medication on cardiac structure and function in any form of hypertrophic cardiomyopathy," says Sara Saberi, M.D., an assistant professor of internal medicine and a cardiologist at the Michigan Medicine Frankel Cardiovascular Center.

Learn more about HCM:

Current options for HCM involves making patients feel better or ‘treating the symptoms’ rather than the structural heart abnormalities. Although a rare disease, there is still a need for effective therapeutics.

"There's a huge void. HCM is a chronic progressive disease that still does not have a cure," Saberi says.

Findings were published in Circulation which address the underlying causes of HCM involving a motor protein and the examined drug ‘mavacamten’.

“The medication works by blocking a protein called myosin from interacting too much with other motor proteins, which then allows the heart muscle to squeeze and relax more normally,” Saberi explains. "It's the first class of medications that actually targets the underlying pathophysiology of HCM."

Specifically, the study measured mass reduction in the heart of participants.

"Cardiac MRI has such incredible visual and spatial resolution that you can accurately examine the heart's mass, volume, ejection fraction, or how well the blood is pumping, and fibrosis, which is the scar burden in the heart muscle," Saberi says.

"It's also encouraging that we don't see a worsening in fibrosis along with the normalization in ejection fraction," she says. Patients originally had a very high ejection fraction, but after treatment it moved into the normal range.

Source: Science Daily     

About the Author
  • Nouran earned her BS and MS in Biology at IUPUI and currently shares her love of science by teaching. She enjoys writing on various topics as well including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
NOV 20, 2020
Drug Discovery & Development
Hyperbaric Oxygen Treatments Reverse Aging
NOV 20, 2020
Hyperbaric Oxygen Treatments Reverse Aging
Researchers from Israel have found that hyperbaric oxygen treatments (HBOT) in healthy aging adults can prevent blood ce ...
NOV 26, 2020
Drug Discovery & Development
Sestrin Increases the Lifespan of Fruit Flies
NOV 26, 2020
Sestrin Increases the Lifespan of Fruit Flies
Reduced food intake, known as dietary restriction, leads to a longer lifespan in many animals and can improve health in ...
DEC 18, 2020
Drug Discovery & Development
Lab-Induced Hallucinations Could Help Develop New Drugs
DEC 18, 2020
Lab-Induced Hallucinations Could Help Develop New Drugs
Researchers from the University of New South Wales in Australia have found that inducing hallucinations in healthy subje ...
DEC 24, 2020
Drug Discovery & Development
Diabetic Drug Combo Improves Symptoms
DEC 24, 2020
Diabetic Drug Combo Improves Symptoms
Scientists have shown that adding a drug combination widely used in diabetic therapy will control blood glucose and weig ...
DEC 27, 2020
Drug Discovery & Development
Attacking Mitochondria in Tumors
DEC 27, 2020
Attacking Mitochondria in Tumors
Researchers found that attacking a cell’s mitochondria can starve cancer cells. The study involves a possible ther ...
JAN 09, 2021
Drug Discovery & Development
Anticoagulant Drugs Prevent Cancer Spreading to Brain
JAN 09, 2021
Anticoagulant Drugs Prevent Cancer Spreading to Brain
Researchers from the Heidelberg University in Germany have found that anticoagulant drugs that inhibit thrombin (an enzy ...
Loading Comments...