FEB 07, 2021 9:20 AM PST

Beta-Blockers Can Repair Broken Blood Vessels

WRITTEN BY: Nouran Amin

Propranolol is a drug that can treat infantile haemangiomas but was found to also treat a blood vessel condition that leads to cerebral cavernous malformations. Findings were reported in the scientific journal Stroke.

"Up to now, there's been no drug treatment for these patients, so our results may become hugely important for them," says Peetra Magnusson of the University's Department of Immunology, Genetics and Pathology, who headed the study.

Cerebral cavernous malformations (CCM) are vascular lesions present on blood vessels of brain. A treatment option for these lesions involves an operation that can be risky.

Learn more about the condition of CCM:

"We examined mice with vascular malformations in the brain -- cavernomas or CCMs, as they're called -- that corresponded to the hereditary form of the condition in humans. The mice were given propranolol in their drinking water, and we were able to see that the cavernomas were becoming fewer and smaller. The blood vessels functioned better, too, with less leaking and improved contacts between their cells," Magnusson says.

"What makes the study especially interesting is that right now, in Italy, a clinical study is under way in which CCM patients are to get two years' treatment with propranolol. During this period, they're being monitored by means of magnetic resonance imaging of the blood vessels, to see how the malformations are developing," says Professor Elisabetta Dejana of Uppsala University's Department of Immunology, Genetics and Pathology and IFOM in Italy.

Source: Science Daily

About the Author
  • Nouran is a scientist, educator, and life-long learner with a passion for making science more communicable. When not busy in the lab isolating blood macrophages, she enjoys writing on various STEM topics.
You May Also Like
JAN 07, 2021
Drug Discovery & Development
Novel Drug To Treat Osteoporosis
JAN 07, 2021
Novel Drug To Treat Osteoporosis
A novel drug to treat osteoporosis comes with fewer side effects and may potentially be a new option for patients. The s ...
JAN 10, 2021
Drug Discovery & Development
New Treatment for Botulism
JAN 10, 2021
New Treatment for Botulism
Researchers discover a new way to reverse botulism which can often lead to paralysis. Botulism is caused by the most pot ...
FEB 18, 2021
Cell & Molecular Biology
Inhibition of a Specific Enzyme Could be a Way to Treat Glioblastoma
FEB 18, 2021
Inhibition of a Specific Enzyme Could be a Way to Treat Glioblastoma
Researchers may have identified a new treatment target for a deadly form of brain cancer. Inhibiting an enzyme called PR ...
MAR 01, 2021
Microbiology
New Therapeutic Potential for a 'Miracle Poison'
MAR 01, 2021
New Therapeutic Potential for a 'Miracle Poison'
Most people know botulism as a nasty disease and botox as a wrinkle reducer that may cause a 'frozen' look if it's overu ...
MAR 15, 2021
Cell & Molecular Biology
When Sample Temperature Matters: How to Keep Your Cool in the Lab
MAR 15, 2021
When Sample Temperature Matters: How to Keep Your Cool in the Lab
Temperature control is critical to many molecular and cellular experiments, but managing sample temperature requires eit ...
APR 14, 2021
Cancer
Cell Viability- Where to Begin?
APR 14, 2021
Cell Viability- Where to Begin?
Written By: Author As I pondered the title of this article, my thoughts immediately went back to a request by my Ph.D. a ...
Loading Comments...