FEB 18, 2021 9:56 AM PST

Weight-Loss Hormone Prevents Muscle-Loss

WRITTEN BY: Nouran Amin

Scientists from the University of Southern California Leonard Davis School of Gerontology, show that a hormone known to prevent weight-gain may also prevent muscle-loss. The results of the study were published in the American Journal of Physiology-Endocrinology and Metabolism and discuss the beneficial effects of the hormone, MOTS-c, which is also a mitochondrial-derived peptide.

The authors of the study demonstrate for the very first time "that MOTS-c modulates the CK2-PTEN-AKT-FOXO1 pathway to inhibit myostatin expression and muscle wasting,"

"Knowing the signaling pathway affected by MOTS-c is really important to the discovery of possible treatments," says corresponding author Su Jeong Kim, a research associate professor at the USC Leonard Davis School. "This insight provides a target for potential drug development efforts and can be rapidly translated into clinical trials of MOTS-c and related analogues."

"Taken together, our work suggests that MOTS-c can address mitochondrial dysfunction," says Pinchas Cohen, professor of gerontology, medicine and biological sciences and dean of the USC Leonard Davis School.

"This study can help improve healthy aging by opening up new avenues for research on how to treat conditions such as insulin resistance-induced skeletal muscle atrophy as well as other muscle-wasting conditions, including sarcopenia."

Source: Science Daily

About the Author
BS/MS
Nouran is a scientist, educator, and life-long learner with a passion for making science more communicable. When not busy in the lab isolating blood macrophages, she enjoys writing on various STEM topics.
You May Also Like
APR 19, 2022
Drug Discovery & Development
Repurposing an Alcoholism Drug to Treat Anxiety
APR 19, 2022
Repurposing an Alcoholism Drug to Treat Anxiety
Anxiety is the most common mental illness in the U.S. According to the National Institutes of Health, nearly a third of ...
APR 19, 2022
Health & Medicine
Pandemic Creates Opportunity to Study Rare Vaccine Side Effects
APR 19, 2022
Pandemic Creates Opportunity to Study Rare Vaccine Side Effects
The Global Vaccine Data Network (GVDN) is a project conceived over 10 years ago to study vaccine side effects. Back then ...
MAY 13, 2022
Health & Medicine
Increased Mental Health Risks Linked to High Potency Cannabis Concentrates
MAY 13, 2022
Increased Mental Health Risks Linked to High Potency Cannabis Concentrates
As more states legalize cannabis for medical and recreational purposes, the association between excessive cannabis consu ...
MAY 19, 2022
Neuroscience
The Unconscious Brain at Work
MAY 19, 2022
The Unconscious Brain at Work
A study published in Neuron revealed how different cell types in the cerebral cortex change their activity during genera ...
MAY 25, 2022
Neuroscience
Exploring Drug Targets in Neurodegenerative Diseases
MAY 25, 2022
Exploring Drug Targets in Neurodegenerative Diseases
Introduction Life expectancy has increased globally over the last several decades. However, longer life expectancy comes ...
MAY 25, 2022
Neuroscience
The Connection Between Bizarre Dreams and Deeper Learning
MAY 25, 2022
The Connection Between Bizarre Dreams and Deeper Learning
A study published in eLife found that wakefulness, non-REM, and REM sleep have complementary functions for learning. Uni ...
Loading Comments...