MAY 12, 2022 9:30 AM PDT

Gut Bacteria Composition Predicts Resposnse to Statins

WRITTEN BY: Annie Lennon

The composition of the gut microbiome is predictive of patient responses to statins. The corresponding study was published in Med

While statins generally lower cholesterol across patients, differences in individual responses have confounded researchers for some time. Genetic markers explain some of these differences and so are used clinically to guide personalized statin treatment regimes. However, as genetic markers alone don't explain all patient responses, researchers are investigating other avenues too. 

As human gut bacteria metabolize statins in vitro, the researchers behind the present study set out to see whether and how microbiome composition may contribute to both on-target and adverse effects from statins. 

For the study, they built statistical models from microbiome, metabolome, human genome, and clinical records from an American cohort including 1848 people. They then validated their results on a European cohort of 991 people. 

In the end, the researchers found that microbiomes enriched with Bacteroides and lower levels of diversity tended to have the strongest LDL-lowering response to statins. This composition, however, was also linked to significant disruption in glucose levels. 

The researchers further found that people with a Ruminococcaceae enriched microbiome showed a clear LDL-lowering response and were protected from the adverse side effects of insulin resistance. 

The results also demonstrated that variability in statin response by the microbiome occurred independently of the genome. This means that microbiome composition and genetic markers could potentially be used in tandem to predict patient response to statins. 

"It would be great to take this knowledge about the genome and the microbiome and predict personalized dosing regimens for a cohort of patients, and then follow these patients forward in time, tracking their metabolic health and their LDL cholesterol levels, to show that this population of patients undergoing a precision intervention do better than a control group of patients who are getting what is normally prescribed," said ISB Assistant Professor Dr. Sean Gibbons Ph.D., a corresponding author on the paper.


Sources: Science Daily, ISB Science, Med

About the Author
University College London
Annie Lennon is a writer whose work also appears in Medical News Today, Psych Central, Psychology Today, and other outlets. When she's not writing, she is COO of Xeurix, an HR startup that assesses jobfit from gamified workplace simulations.
You May Also Like
MAY 02, 2022
Drug Discovery & Development
Synthetic Coating Improves Survival of Oral Medications During Digestion
MAY 02, 2022
Synthetic Coating Improves Survival of Oral Medications During Digestion
We’re probably all familiar with the (sometimes unpleasant) experience of swallowing pills. Whether ibuprofen for ...
MAY 19, 2022
Drug Discovery & Development
Vaccine for Deadly Mosquito-borne Virus Shows Promising Trial Results
MAY 19, 2022
Vaccine for Deadly Mosquito-borne Virus Shows Promising Trial Results
Eastern equine encephalitis virus (EEEV), Western equine encephalitis (WEEV), Venezuelan equine encephalitis (VEEV) are ...
MAY 19, 2022
Drug Discovery & Development
Experimental Drug Shows Promise Against ALS
MAY 19, 2022
Experimental Drug Shows Promise Against ALS
A new experimental drug known as NU-9 may be more effective in treating ALS than existing FDA-approved drugs. The corres ...
JUN 04, 2022
Drug Discovery & Development
3g of Omega-3 Fatty Acids Daily May Lower Blood Pressure
JUN 04, 2022
3g of Omega-3 Fatty Acids Daily May Lower Blood Pressure
Around 3g of omega-3 fatty acids taken on a daily basis may be the optimal dose for lowering blood pressure. The corresp ...
JUN 15, 2022
Plants & Animals
Using Mosquito Spit to Develop Vaccines for Zika, Yellow Fever, Dengue
JUN 15, 2022
Using Mosquito Spit to Develop Vaccines for Zika, Yellow Fever, Dengue
Mosquitoes, specifically, the Aedes mosquito, can carry and transmit deadly virsues like the Zika virus and the viruses ...
JUN 29, 2022
Microbiology
Unleashing the Genetic Power of Ocean Microbes
JUN 29, 2022
Unleashing the Genetic Power of Ocean Microbes
By analyzing over 1,000 samples of the marine environment, researchers have reconstructed the genomes of 25,000 novel mi ...
Loading Comments...