JUN 24, 2022 3:20 PM PDT

Pain Medications with High Abuse Potential More Likely to Achieve Approval

WRITTEN BY: Annie Lennon

Researchers found that pain medications with a high potential for abuse are more likely to be approved than medications with lower abuse potential. The corresponding study was published in Anesthesiology

“The opioid crisis was a wake-up call for medicine as a whole,” said Dermot P. Maher, M.D., M.S., M.H.S., assistant professor, John Hopkins University School of Medicine, Baltimore, one of the study's authors. 

“On the one hand, we had patients who were simply asking for their pain to be addressed. On the other hand, physicians had very little in their pharmaceutical toolbox that was either remarkably effective, non-addictive or lacked major side effects," he added. 

For the study, researchers analyzed 469 pain pharmaceutical development programs conducted between 2000 and 2020 from the Citeline database involving 399 unique active pharmaceutical ingredients. Their analysis involved probabilities of success, duration, and survivorship from pain medication according to the phase, type of pain, and the potential for abuse. 

The researchers noted that over the period, the overall probability of successful development of pain medications from development to approval was 10.4%. Whereas 13.3% of medications for nociceptive pain- such as sprains, burns, or bruises- were approved, the same was true for 7.1% of drugs for neuropathic pain- pain that arises from damage to nerves. They further noted that the most common period for attrition was between the Phase 3 clinical trial and approval. 

From their analysis, they found that while 27.8% of medications with a high abuse potential were successfully developed and approved, the same was true for only 4.7% of mediations with low abuse potential. This remained even though the number of drugs with a high abuse potential under development decreased following the peak of the opioid epidemic in 2010. 

“The higher probability of successful development could represent a more thorough biological understanding of pain signaling pathways targeted by medications with high abuse potential compared to the novel mechanisms offered by alternative medications with lower abuse potential,” said the authors of the research. 

The researchers concluded that unique attributes of pain medications, including their abuse potential and intended pathology, can influence their probability of successful development, as well as the duration of their development. 

They noted, however, that their study has several limitations. As their study was conducted retrospectively, they note that it cannot accurately predict the success of future development programs. They added that while they tried to include as many drug development programs as possible in their analysis, it is possible that they missed some. 

 

Sources: Neuroscience NewsAnesthesiology

About the Author
University College London
Annie Lennon is a writer whose work also appears in Medical News Today, Psych Central, Psychology Today, and other outlets. When she's not writing, she is COO of Xeurix, an HR startup that assesses jobfit from gamified workplace simulations.
You May Also Like
JUN 07, 2022
Health & Medicine
Drug that lowers blood sugar also reduces blood vessel dysfunction caused by aging
JUN 07, 2022
Drug that lowers blood sugar also reduces blood vessel dysfunction caused by aging
Cardiovascular diseases (CVDs) are the leading cause of death globally, taking an estimated 17.9 million lives ...
JUN 09, 2022
Cardiology
Supplements and Heart Health
JUN 09, 2022
Supplements and Heart Health
There is little evidence that supplements actually improve heart health.
AUG 02, 2022
Cell & Molecular Biology
A New, Innovative Process for Clarifying and Sterile Filtering Cells for Protein Purification Workflows
AUG 02, 2022
A New, Innovative Process for Clarifying and Sterile Filtering Cells for Protein Purification Workflows
Introduction Centrifugation and filtration have been widely accepted as techniques required for clarifying complex cell ...
JUN 27, 2022
Plants & Animals
Developing a New Approach to Rabies Vaccination
JUN 27, 2022
Developing a New Approach to Rabies Vaccination
Rabies is a viral disease that can spread through the saliva. Several kinds of animals can get rabies, including humans ...
JUL 19, 2022
Drug Discovery & Development
Experimental Cancer Drug Regrows Nerves in Spinal Cord Injury
JUL 19, 2022
Experimental Cancer Drug Regrows Nerves in Spinal Cord Injury
An experimental cancer drug can regenerate damaged nerves following spinal trauma in mice and rats. The corresponding re ...
JUL 28, 2022
Cannabis Sciences
FDA Approved Cannabis Drug Products
JUL 28, 2022
FDA Approved Cannabis Drug Products
The FDA has approved some cannabis infused drugs for medical usage. Here's what they are.
Loading Comments...