JUL 06, 2022 2:10 PM PDT

Promising New Treatment Strategy for Psoriasis and Psoriatic Arthrtis

WRITTEN BY: Annie Lennon

Researchers have identified a new potential strategy for inhibiting inflammation in both psoriasis and psoriatic arthritis. The corresponding study was published in the Annals of the Rheumatic Diseases by researchers in Austria. 

Over 8 million people in the US have psoriasis. Around a third of people with the condition go on to develop psoriatic arthritis. Thought to be an autoimmune condition, its triggers include infections, stress, and cold. It typically appears as rashes or plaques on the skin; however, can sometimes affect the nails and joints too as in psoriatic arthritis. 

In the present study, researchers reported that inhibiting S100A9, a gene linked to psoriasis, can reduce psoriasis severity throughout the body- and not just the skin. 

Although these findings came from mouse models, they confirmed that the mechanism might work similarly in humans due to analyses of S100A9 expression in skin, serum, and synovial fluid samples from people with psoriasis and psoriatic arthritis. 

They found, for example, that patients with psoriatic arthritis had significantly higher blood levels of S100A9, alongside several immune and inflammatory cells than patients with psoriasis alone. They further noted that levels of S100A9 and calprotectin- an inflammatory protein- could be used to distinguish between healthy individuals, those with psoriasis, and those with psoriatic arthritis. 

"Our study is an important step towards the development of targeted therapeutic options in the form of drugs that act systemically rather than locally on the skin," said Erwin Wagner from the Department of Dermatology and Department of Laboratory Medicine at the Medical University of Vienna. 

"We now know that the inflammatory responses in psoriasis and psoriatic arthritis are enhanced when S100A9 is only inhibited in skin cells," she continued. Drugs inhibiting S100A9 via tablets or drips may thus be able to treat the condition systematically.

 

Sources: Science DailyAnnals of the Rheumatic Diseases

 

About the Author
University College London
Annie Lennon is a writer whose work also appears in Medical News Today, Psych Central, Psychology Today, and other outlets. When she's not writing, she is COO of Xeurix, an HR startup that assesses jobfit from gamified workplace simulations.
You May Also Like
JUN 14, 2022
Coronavirus
Advances in Latest Coronavirus Research in the 2022 Ongoing Labroots Virtual Event Series
JUN 14, 2022
Advances in Latest Coronavirus Research in the 2022 Ongoing Labroots Virtual Event Series
Labroots hosted its 3rd annual Coronavirus Conference Virtual Event Series on May 4, 2022. The speaker roster for this f ...
AUG 02, 2022
Cell & Molecular Biology
A New, Innovative Process for Clarifying and Sterile Filtering Cells for Protein Purification Workflows
AUG 02, 2022
A New, Innovative Process for Clarifying and Sterile Filtering Cells for Protein Purification Workflows
Introduction Centrifugation and filtration have been widely accepted as techniques required for clarifying complex cell ...
JUL 13, 2022
Neuroscience
Listen Up: Sound Provides Pain Relief
JUL 13, 2022
Listen Up: Sound Provides Pain Relief
People often think of pharmaceutical treatments and meditation to ease physical pain, but pain can be alleviated with mu ...
AUG 12, 2022
Cannabis Sciences
Study Shows Water Soluble CBD Has Better Absorption than Oil-Based CBD Products
AUG 12, 2022
Study Shows Water Soluble CBD Has Better Absorption than Oil-Based CBD Products
Colorado State University researchers examined the pharmacokinetics of cannabidiol (CBD) and its impact on liver functio ...
AUG 07, 2022
Drug Discovery & Development
Monoclonal Antibody Treatment Shows Promise in Preventing Malaria
AUG 07, 2022
Monoclonal Antibody Treatment Shows Promise in Preventing Malaria
A singular injection of a monoclonal antibody treatment candidate has been shown as safe and highly protective in US adu ...
AUG 12, 2022
Technology
Bioengineered Cornea Helps Restore Sight for the Visually Impaired
AUG 12, 2022
Bioengineered Cornea Helps Restore Sight for the Visually Impaired
Corneal disease refers to a range of conditions that can cause significant damage to the cornea, the clear tissue layer ...
Loading Comments...