JUN 06, 2018 12:49 AM PDT

Metformin Safe for Diabetics with CKD

WRITTEN BY: Nouran Amin

An oral diabetes drug, by the name of metformin, is suggested to be safe for most diabetic individuals with chronic kidney disease (CKD) according to a recent research study.

For the treatment of type 2 diabetes, Metformin is prescribed as the first-line medication. However, the use of Metformin has raised concerns in the medical community because it is believed that it may lead to lactic acidosis, explains a senior study author Morgan Grams, M.D.,Ph.D., M.H.S., an associate professor of medicine and epidemiology at the Johns Hopkins University School of Medicine.

A rare but serious complication, lactic acidosis is caused by lactate accumulation in the bloodstream that leads to severe muscle pain, cramps, and weakness. This means that diabetic individuals with CKD hold an increased risk of metformin-associated lactic acidosis. An effective examination of lactic acidosis risk could "provide reassurance that millions of people with diabetes and CKD may be able to safely use metformin," explains Grams. Older studies show that metformin holds great benefits beyond the purview blood sugar control. These benefits include less weight gain, lower risk of a heart attack, and higher long-term survival than other blood-sugar controlling prescriptions. "Our study demonstrates that the first-line and common diabetes medication is safer in patients with CKD than once thought," Grams says. "From a public health perspective, the potential benefits of using metformin for patients with diabetes and CKD are vast, given the increasing number of people affected with both diseases worldwide."

For the research study, Grams and co-authors examined 2004-2017 medical record data taken from 75,413 patients with type 2 diabetes managed by Geisinger Health System in Pennsylvania. Investigators analyzed data from the patients' estimated glomerular filtration rates (eGFRs -- a measure of kidney function), prescription drugs used for diabetes management, acidosis hospitalization visits, demographics, smoking habits/status and any indication of cardiovascular disease. The researchers used computer-based statistical models to study the risk of acidosis development in metformin users in comparison to metformin nonusers. Some conditions were adjusted for cardiovascular disease and smoking status. Overall, the research team found a relationship between metformin use and acidosis which was evident in patients with severely decreased kidney function. The researchers found a strikingly high risk in patients with severely decreased kidney function who were on a different type of diabetic medication. Additionally, the investigators compared new metformin users with new users of other diabetic managing drugs known as sulfonylureas within different categories of CKD stages.

"Our results support cautious use of metformin in patients with type 2 diabetes and eGFR of at least 30 mL/min/1.73 m2," Grams says. While investigators believe that this data is promising, they warn that patients receiving metformin may have varying underlying risk of lactic acidosis than patients who have not received metformin.

Source: Johns Hopkins Medicine

About the Author
  • Nouran enjoys writing on various topics including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
OCT 16, 2018
Drug Discovery
OCT 16, 2018
Anti-Venomous Plant Compound
According to a study published in PLOS Neglected Tropical Diseases, researchers at the Institute Butantan, São Paulo, Brazil, have discovered a flav...
NOV 07, 2018
Drug Discovery
NOV 07, 2018
Modifying Antibiotics For Drug Resistant Infections
In a study published in Nature Chemistry, researches at MIT were able to create a new chemical reaction that has the ability to modify antibiotics to make ...
NOV 07, 2018
Drug Discovery
NOV 07, 2018
Zebrafish Bacterial Gut Protein Delays Death by Septic Shock
At the University of Oregon, researchers identified a novel anti-inflammatory protein that is secreted by the common gut bacterium in zebrafish. The protei...
NOV 15, 2018
Drug Discovery
NOV 15, 2018
Making Cancer Disappear?
Neuroblastoma is one of the most common childhood cancers and the leading cause of cancer deaths among pediatric patients younger than 5. The cancer is fre...
NOV 29, 2018
Cannabis Sciences
NOV 29, 2018
Want to Smoke Weed? For Science?
Clinical trials are a necessary part of the drug approval process. All drugs on the market, even the over-the-counter drugs, have gone through clinical tri...
JAN 06, 2019
Cell & Molecular Biology
JAN 06, 2019
An Inhalable Form of Messenger RNA Might be a New Kind of Therapeutic
Messenger RNA normally carries genetic information from the genome to the ribosome, but researchers want to use it to treat disease....
Loading Comments...