SEP 24, 2018 09:01 PM PDT

Further Challenges in Alzheimer Drug Development

WRITTEN BY: Nouran Amin

Image via stress.com

Scientists at Trinity College Dublin performed a large-scale international study involving the treatment of Alzheimer's disease, which was published in PLOS Medicine. The research involved a clinical trial testing a new treatment against a placebo. The study involved a clinical trial, known as NILVAD, which tested 511 participants with mild to moderate Alzheimer’s disease. The clinical trial was testing a new treatment, a medication called Nilvadipine, against a placebo.

The drug, Nilvadipine, is approved to treat high blood pressure. However, in animal studies, it was found to reduce brain amyloid, the toxic protein associated with Alzheimer's disease. Thus, Nilvadipine was seen as a potential treatment for Alzheimer’s. It was therefore considered to be a possible effective treatment for Alzheimer's disease in patients.

The most common form of dementia, Alzheimer's disease affects approximately 34 million people worldwide and as of now, there is no treatment that can delay the onset or slow the progression of the disease.

Results of the study showed that although Nilvadipine is tolerable in individuals with Alzheimer's disease. No effects on memory and function were evident from the drug treatment. "The outcome of the trial for the overall combined group of people with mild and moderate Alzheimer's disease was negative; however, when we broke it down according to severity, those with mild disease appeared to benefit from Nilvadipine whereas those with moderate disease seemed to do worse on the medication. These findings will need to be followed up and teased apart in future studies. It may be that to be successful, we would need to target people at the earliest phase of the disease process,” explains lead author of the study, Professor of Brian Lawlor.

Findings from the paper further implicate drug development for Alzheimer’s.

Source: PLOS Medicine

About the Author
  • Nouran enjoys writing on various topics including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
JUN 20, 2018
Drug Discovery
JUN 20, 2018
New Drug 'Moxidectin' for River Blindness
A new treatment to help eliminate a neglected tropical disease was developed thanks in part to an incentive program devised by researchers at Duke Universi...
JUL 04, 2018
Drug Discovery
JUL 04, 2018
Increased Dose of Drug 'Rifampin' Effective in Eliminating Tuberculosis Bacterium
According to a randomized controlled trial, a TB drug by the name ‘Rifampin’ was seen to effectively kill TB bacteria in sputum cultures when a...
JUL 04, 2018
Drug Discovery
JUL 04, 2018
Identifying New Drug Targets in Therapy-Resistant Cancers
Recent research published in the Nature Partner journal Systems Biology and Applications examines how genome-wide data used in collaboration with systems b...
JUL 19, 2018
Cell & Molecular Biology
JUL 19, 2018
Stopping Structural Changes in Collagen may Prevent Lung Fibrosis
Lung fibrosis is a serious condition that thickens tissues in the lungs and makes it hard to breathe....
JUL 24, 2018
Drug Discovery
JUL 24, 2018
The Chili Pepper Drug Aims To Combat Obesity
A new drug was recently developed based on capsaicin, the compound found in chili peppers that is responsible for their spicy properties, was seen to cause...
AUG 07, 2018
Drug Discovery
AUG 07, 2018
Improving Liver Cancer Therapy
According to studies conducted in the United States, the ninth leading causes of cancer deaths is hepatocellular carcinoma, the primary cancer of the liver...
Loading Comments...