APR 07, 2015 03:45 PM PDT

Mummies Show How TB Ravaged Heart of 18th Century Europe

WRITTEN BY: Judy O'Rourke
Bodies found in a 200 year-old Hungarian crypt have revealed secrets of how tuberculosis (TB) took hold in 18th century Europe, according to a research team led by the University of Warwick, UK.

A new study published in Nature Communications details how samples taken from naturally mummified bodies found in an 18th century crypt in the Dominican church of Vác in Hungary have yielded 14 tuberculosis genomes, suggesting that mixed infections were common when TB was at peak prevalence in Europe.

"Microbiological analyses of samples from contemporary TB patients usually report a single strain of tuberculosis per patient," says Mark Pallen, PhD, professor of microbial Genomics, Warwick Medical School and the lead author. "By contrast, five of the eight bodies in our study yielded more than one type of tuberculosis - remarkably from one individual we obtained evidence of three distinct strains."

The research team was comprised of collaborators from the Universities of Warwick and Birmingham, University College London, the Hebrew University in Jerusalem, and the Hungarian Natural History Museum in Budapest. Pallen says the discovery is significant for current and future infection control and diagnosis.

The team used a technique called metagenomics to identify TB DNA in the historical specimens-that is, direct sequencing of DNA from samples without growing bacteria or deliberately fishing out TB DNA. This approach draws on the remarkable throughput and ease of use of modern DNA sequencing technologies.

"Poignantly, we found evidence of an intimate link between strains from in a middle-aged mother and her grown-up daughter, suggesting both family members died from this devastating infection," says Gemma Kay, first author on the paper.

The team used the 18th century sequences to date the origin of the lineage of TB strains commonly found in Europe and America to the late Roman period, which fits in with the recent controversial suggestion that the most recent common ancestor of all TB strains occurred as recently as 6,000 years ago.

"By showing that historical strains can be accurately mapped to contemporary lineages, we have ruled out, for early modern Europe, the kind of scenario recently proposed for the Americas-that is wholesale replacement of one major lineage by another-and have confirmed the genotypic continuity of an infection that has ravaged the heart of Europe since prehistoric times," Pallen says.

With TB resurgent in many parts of the world, the struggle to contain this ancient infection is far from over, he adds. "We have shown that metagenomic approaches can document past infections," Pallen says. "However, we have also recently shown that metagenomics can identify and characterize pathogens in contemporary samples, so such approaches might soon also inform current and future infectious disease diagnosis and control."

The article in Nature Communications is "Eighteenth-century genomes show that mixed infections were common at time of peak tuberculosis in Europe."

[Source: University of Warwick]
About the Author
  • Judy O'Rourke worked as a newspaper reporter before becoming chief editor of Clinical Lab Products magazine. As a freelance writer today, she is interested in finding the story behind the latest developments in medicine and science, and in learning what lies ahead.
You May Also Like
NOV 17, 2018
Videos
NOV 17, 2018
Using Genetic Research to Improve Animal Conservation and Care
A group of Peters's Angolan colobus monkeys were brought to US zoos from East Africa in the 80s, but little is known about them....
NOV 20, 2018
Videos
NOV 20, 2018
A Major Grant Aims to Improve our Understanding of Age-related Cognitive Decline
The American Heart Association has teamed up with the Allen Initiative in Brain Health and Cognitive Impairment to award the Salk Institute $19.2 million....
NOV 29, 2018
Genetics & Genomics
NOV 29, 2018
Pet Genomics Might Need to be Leashed
Experts say genetic testing for pets is not quite ready for the market, but that hasn't stopped companies from selling tests....
DEC 11, 2018
Genetics & Genomics
DEC 11, 2018
Dust with High Levels of Triclosan has More Antibiotic Resistance Genes
Researchers have found that some dust contains high amounts of a common antimicrobial agent called triclosan....
DEC 18, 2018
Genetics & Genomics
DEC 18, 2018
Hands Off! Plants Don't Like to be Touched
Some people have a green thumb, but that doesn't mean that plants enjoy feeling it....
DEC 22, 2018
Videos
DEC 22, 2018
Using Genomics to Fight Cancer
Genetic sequencing can help clinicians decide on the best treatment for individual patients....
Loading Comments...